DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and MAP4K3

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	NP_003609.2	Gene:	MAP4K3 / 8491	HGNCID:	6865	Length:	894	Species:	Homo sapiens

Alignment Length:	648	Identity:	207/648 - (31%)
Similarity:	295/648 - (45%)	Gaps:	149/648 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIA 90
            ::|...||||:.:|:||||.|||.|:..||:||||||:.:...|:..:..:..::.|...|.||.
Human    10 RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIV 74

  Fly    91 TYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNK 155
            .|:|:::::      |:||:.||:||.||:.|:...|  ..|.|..|||:.||.|:||.||||..
Human    75 AYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRETLQGLYYLHSKG 131

  Fly   156 VIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNR 220
            .:||||||.|:|||||..|||.|||||||:..||.:|.:||||||||||||.|.:..  ..|:..
Human   132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK--GGYNQL 194

  Fly   221 SDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS--PPRLKSK-KWSKKFHGFIDTVLVKDYH 282
            .|||::||||:|:||.|||:.||||||||||:.:::  ||:||.| |||..||.|:...|.|:..
Human   195 CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPK 259

  Fly   283 QRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEPQLAGEHS 347
            :||..|.||:|.|:....| |.:.|:|.|.::         ..:...|...|:||.||.:|..|.
Human   260 KRPTAEKLLQHPFVTQHLT-RSLAIELLDKVN---------NPDHSTYHDFDDDDPEPLVAVPHR 314

  Fly   348 SIVQAPGGDTLRRN-----------FQQIQEGRLAAEQQQQHHLMAQAQA---QAAAAHAAAQAQ 398
            .       .:..||           |.|::......::.:.||.:..:..   .:...:..|::.
Human   315 I-------HSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSN 372

  Fly   399 AQLQQQQQQA-------AAAAAAAAHAAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPAR 456
            ..||.:..|.       .|..:......::..|....|..:..:.:......|..:.:.| ||..
Human   373 LDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIP-PPLP 436

  Fly   457 PPQRLIVVPDPPHANR-----PLPPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPEPQPQTAA 516
            |..:.|.:|...|:..     .:...|..|.||               |||..|.||.|
Human   437 PKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPA---------------KPSQVPPRPPP------ 480

  Fly   517 GGQGSQQQAQPEAPPRNN-RQSSGLSS--SGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPL 578
                      |..||... ...:|:||  ..|...|         :|.||.|.|
Human   481 ----------PRLPPHKPVALGNGMSSFQLNGERDG---------SLCQQQNEH----------- 515

  Fly   579 DSSDSDSEPDEPNDRARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTP 641
                              .||.|:....|.:|            .|:|:|        |||||
Human   516 ------------------RGTNLSRKEKKDVP------------KPISNG--------LPPTP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	135/272 (50%)
		S_TKc	32..296	CDD:214567	134/266 (50%)
		CNH	1183..1484	CDD:214481
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	134/267 (50%)
		S_TKc	16..273	CDD:214567	134/266 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..536		41/215 (19%)
		CNH	561..874	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910