DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and STK24

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_016876283.1	Gene:	STK24 / 8428	HGNCID:	11403	Length:	517	Species:	Homo sapiens

Alignment Length:	354	Identity:	149/354 - (42%)
Similarity:	217/354 - (61%)	Gaps:	40/354 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDV--TEDEEEEIKLEINVLKKYSNHRNI 89
            ||..:|..:|.:|.|::|:|:||...:|.::.|||::|:  .|||.|:|:.||.||.: .:...:
Human   105 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQ-CDSPYV 168

  Fly    90 ATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN 154
            ..|||:::      ||.:||::|||.|.||..||::.   ..|.|..||.|.||||:||.||||.
Human   169 TKYYGSYL------KDTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREILKGLDYLHSE 224

  Fly   155 KVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDN 219
            |.||||||..||||:::.||||.||||:.||..|..:||||:|||:|||||||     ..:.||:
Human   225 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----KQSAYDS 284

  Fly   220 RSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQR 284
            ::|:|||||||:|:|..:||..:||||:.|||||:|:||.|:. .:||....|::..|.|:...|
Human   285 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-NYSKPLKEFVEACLNKEPSFR 348

  Fly   285 PYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEPQLAGEHSSI 349
            |..:.||||.||.   .:.:....|.:.|||.|:.|.|:..:|     |.::|.:.:..|
Human   349 PTAKELLKHKFIL---RNAKKTSYLTELIDRYKRWKAEQSHDD-----SSSEDSDAETDG----- 400

  Fly   350 VQAPGGD-------TLR-RNFQQIQEGRL 370
             ||.||.       |:| ::.:.::.|.|
Human   401 -QASGGSDSGDWIFTIREKDPKNLENGAL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	128/270 (47%)
		S_TKc	32..296	CDD:214567	126/265 (48%)
		CNH	1183..1484	CDD:214481
STK24	XP_016876283.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910