DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and Tnik

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_006535580.1	Gene:	Tnik / 665113	MGIID:	1916264	Length:	1374	Species:	Mus musculus

Alignment Length:	1550	Identity:	672/1550 - (43%)
Similarity:	862/1550 - (55%)	Gaps:	308/1550 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVL 80
            |||:|||:||:||||||||:|:||||||||||||||.||||||||||||||.|||||||.|||:|
Mouse     9 SLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73

  Fly    81 KKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREIL 145
            ||||:||||||||||||||:|||.|||||||||:|||||||||:|:|||.:||||||||||||||
Mouse    74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

  Fly   146 RGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACD 210
            ||||:||.:|||||||||||||||:||||||||||||||||||:|||||||||||||||||||||
Mouse   139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 203

  Fly   211 ENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDT 275
            ||||||||.:||||||||||:||||..|||||:||||||||||||..||||||||||||..||::
Mouse   204 ENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIES 268

  Fly   276 VLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEP 340
            .|||::.|||.||.|:||.||:|||.:|||||||||||||.||::.||:..:|.||||:.:::|.
Mouse   269 CLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333

  Fly   341 QLAGEHSSIVQAPGGDTLRRNFQQIQEG---------RLAAEQQQQHH------LMAQAQ----- 385
            . :||.|||:..||..||||:|.::|..         |...||||:.:      |:|:.|
Mouse   334 D-SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397

  Fly   386 --AQAAAAHAAAQAQAQLQQQQQQAAAAAAAAAHAAQQ--AQQAAQQAQAQQPQANRQPKPPSRQ 446
              .|........:.:.:|::||::     ....|..:|  .::..::|:.:|....||.:...||
Mouse   398 QKEQRRRLEEQQRREKELRKQQER-----EQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQ 457

  Fly   447 ---------------------QVEEPGPPARPPQR-------LIVVPDPPHANRPLPPTPKCGEP 483
                                 |:||.....|..::       |:.:.......|||...|.....
Mouse   458 LEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYK 522

  Fly   484 AGQTPQQQQRNSQNNFKPSLPPRRPEP-QPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGSA 547
            .|.:|.::...::...:.|...|:..| .|...|     .:.:.|..|||    |...|.||
Mouse   523 EGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVA-----NRISDPNLPPR----SESFSISG--- 575

  Fly   548 SGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSSDSDSEPDEPNDRARNDGTLLASDP--PKPLP 610
                  .:||...|      :.:||:|..|...:.....|           .|.||..  .:|..
Mouse   576 ------VQPARTPP------MLRPVDPQIPQLVAVKSQGP-----------ALTASQSVHEQPTK 617

  Fly   611 GLGPVSEDANTTTPLSHGSGGP-----PNRPLPPTPDDDDQAGDRTLIMKRKLEQNINRLQKSAS 670
            ||....|..|.|   ||....|     |....||.|...::. ||:..::::.:......|::.|
Mouse   618 GLSGFQEALNVT---SHRVEMPRQNSDPTSENPPLPTRIEKF-DRSSWLRQEEDIPPKVPQRTTS 678

  Fly   671 TSQANVTPSRRGDESNLLRDWDFDRFFPKNANGPRGSGRGSPTTTASLSRSSQLSTLKVDTKLQR 735
            .|.|....:..|:.|.|               |||...:....:...|.|:..:    :::.|||
Mouse   679 ISPALARKNSPGNGSAL---------------GPRLGSQPIRASNPDLRRTEPV----LESSLQR 724

  Fly   736 ASVAEAITRPVPRGYQPLKAEPSASQSIAKEQGSASGSGSGSGSASGSGSGGSTNSP--AHKRQD 798
            .|...:.:...|      .::|| ||. ..:.||.:||...|...:.|.|.||...|  ..|.:.
Mouse   725 TSSGSSSSSSTP------SSQPS-SQG-GSQPGSQAGSSERSRVRANSKSEGSPVLPHEPSKVKP 781

  Fly   799 SDSR------LPTNFERGFRRENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRSSAVYQRN 857
            .:||      .|.::::.......|...|||....:                 .::.::...::.
Mouse   782 EESRDITRPSRPASYKKAIDEGEMDLTALAKELREL-----------------RIEETNRPLKKV 829

  Fly   858 SIYSSSI-SSKSKENDVPGAPGAAAAGTATASAKPGPAAATTTATKGAAPKTSKSLANFHFLRPR 921
            :.||||. .|:|.|.:..........||...|..|   ....|...|...:.:..:...|.|...
Mouse   830 TDYSSSSEESESSEEEEEDGESETHDGTVAVSDIP---RLIPTGAPGNNEQYNMGMVGTHGLETS 891

  Fly   922 REKT-------ESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSG 979
            ...|       |..::::..|                      :::.|.|.....|..|
Mouse   892 HADTFGGSISREGTLMIRETA----------------------EEKKRSGHSDSNGFAG------ 928

  Fly   980 VGADGTGLGTPGTRTSSVLPDLLSQA-SPATPP----------RHDKSSSEEYQAAISSSVHSTP 1033
                           ...||||:.|: |||..|          ..:..|..||....|:....||
Mouse   929 ---------------HINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGAEYGIGSSTKASFTP 978

  Fly  1034 SKSFIASSGSGGLGLGGGTVVGGVIISSNHSPQSTISLASSSSNSRQNSPKNSISKTRSSSSITN 1098
               |:                                    .....|.||.:...:...||
Mouse   979 ---FV------------------------------------DPRVYQTSPTDEDEEDDESS---- 1000

  Fly  1099 LLHKSASSSSANLHHLTPCSSTSSASISNPLPPHAYALQQKQRSFLTFGFGAGGSGPSRRESHVN 1163
                                  ::|..::.|      |:|:|...          ..:|:.|.||
Mouse  1001 ----------------------AAALFTSEL------LRQEQAKL----------NEARKISVVN 1027

  Fly  1164 VNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRR 1228
            ||  ||:....:|||||||||||||||||||||||||||:||||||||||||||||||.||:|||
Mouse  1028 VN--PTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRR 1090

  Fly  1229 FQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDLQGAVHFKI 1293
            ||||:||||.|:|||||||||::||||||||:::||..|   .:||::.|||.||||:|.:|:|:
Mouse  1091 FQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHND---PEVEKKQGWITVGDLEGCIHYKV 1152

  Fly  1294 VKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEG 1358
            ||||||||||||||:::|||||||||||||||||:|.:|:|:|||||||:|:..|||||:||..|
Mouse  1153 VKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTG 1217

  Fly  1359 FHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQW 1423
            ||.:|:||...||||:|.|.||.|.||.||.||.::||::|:||::|||||||.||::|::||||
Mouse  1218 FHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQW 1282

  Fly  1424 GEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKV 1478
            ||||||||||.:.||||||.|||||||||:||||||||||:||||||||||||||
Mouse  1283 GEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	230/270 (85%)
		S_TKc	32..296	CDD:214567	224/263 (85%)
		CNH	1183..1484	CDD:214481	221/295 (75%)
Tnik	XP_006535580.1	STKc_TNIK	18..313	CDD:270807	250/294 (85%)
Tnik	XP_006535580.1	CNH	1045..1337	CDD:214481	220/294 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850709
Domainoid	1	1.000	476	1.000	Domainoid score	I431
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1112	1.000	Inparanoid score	I227
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46069
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	1	1.000	-	-		FOG0001422
OrthoInspector	1	1.000	-	-		otm43111
orthoMCL	1	0.900	-	-		OOG6_101812
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6825
SonicParanoid	1	1.000	-	-		X885
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800