DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msn and Stk25

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	NP_067512.3	Gene:	Stk25 / 59041	MGIID:	1891699	Length:	426	Species:	Mus musculus

Alignment Length:	412	Identity:	161/412 - (39%)
Similarity:	237/412 - (57%)	Gaps:	32/412 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDV--TEDEEEEIKLEINVLKKYSNHRNI 89
            ||..:|..::.:|.|::|:||||....|.::.|||::|:  .|||.|:|:.||.||.: .:...|
Mouse    15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ-CDSPYI 78

  Fly    90 ATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN 154
            ..|:|:::|.:      :||::|||.|.||..||:|.   ..|:|.:||.|.||||:||.||||.
Mouse    79 TRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREILKGLDYLHSE 134

  Fly   155 KVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDN 219
            :.||||||..||||::..:|||.||||:.||..|..:||||:|||:|||||||     ..:.||.
Mouse   135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----KQSAYDF 194

  Fly   220 RSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQR 284
            ::|:|||||||:|:|:.:||..||||||.|||||:|:||.|:... ||.|..|::..|.||...|
Mouse   195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHH-SKPFKEFVEACLNKDPRFR 258

  Fly   285 PYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEPQLAGEHSSI 349
            |..:.||||.||...........:|   |||.|:.|.|...|:  .|..|:|.|.....||...|
Mouse   259 PTAKELLKHKFITRYTKKTSFLTEL---IDRYKRWKSEGHGEE--SSSEDSDIDGEAEDGEQGPI 318

  Fly   350 VQAPGGDTLRRN-FQQIQEG-RLAAEQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAAA 412
            ...|  .|:|.: ..::.:| .|.:.|:....:..|.::|..:. .......:|:::.:|:..:.
Mouse   319 WTFP--PTIRPSPHSKLHKGTALHSSQKPAEPIKRQPRSQCLST-LVRPVFGELKEKHKQSGGSV 380

  Fly   413 AAAAHAAQQAQQAAQQAQAQQP 434
            .    |.::.:.|...|:...|
Mouse   381 G----ALEELENAFSLAEESCP 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	130/270 (48%)
		S_TKc	32..296	CDD:214567	128/265 (48%)
		CNH	1183..1484	CDD:214481
Stk25	NP_067512.3	STKc_STK25	15..291	CDD:270810	137/294 (47%)
Stk25	NP_067512.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..354		17/66 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910