DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and Mink1

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_006533740.1	Gene:	Mink1 / 50932	MGIID:	1355329	Length:	1374	Species:	Mus musculus

Alignment Length:	1585	Identity:	697/1585 - (43%)
Similarity:	885/1585 - (55%)	Gaps:	305/1585 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKL 75
            |:...|||||||:||:||||||||:||||||||||||||||.||||||||||||||||||||||.
Mouse     4 PAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQ 68

  Fly    76 EINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYI 140
            |||:|||||:||||||||||||||||||.|||||||||:|||||||||||:|||.:|||:.||||
Mouse    69 EINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133

  Fly   141 CREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPE 205
            ||||||||::||::|||||||||||||||:||||||||||||||||||:||||||||||||||||
Mouse   134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

  Fly   206 VIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFH 270
            |||||||||||||.|||:|||||||:||||..|||||:||||||||||||.|||||||||||||.
Mouse   199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFT 263

  Fly   271 GFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDN 335
            .||||.|:|.|..||.||.|||..||:||||:|||||||||||||.:|::.|||..:|.||||:.
Mouse   264 DFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE 328

  Fly   336 DDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQE----GRLAAEQQQQHHLMAQAQAQAAAAHAAAQ 396
            :||.....||.|||:..||..||||.|.::|:    ...|.:||||.....|...:|...|...|
Mouse   329 EDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393

  Fly   397 AQAQLQQQQQQAAAAAAAAAHAAQQ--AQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPAR--- 456
            .|.::::|:::............:|  .|:..||.:.:..||.|:.:  .|:|.|......|
Mouse   394 RQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE--ERRQAEREQEYIRHRL 456

  Fly   457 -PPQRLIVVPDPPHANRP---LPPTPKCGEPAGQTPQ-QQQRNSQNNFKPSLPPRRPEPQPQTAA 516
             ..||.:.:.........   |....|..|...|:.: |:|...::.:..||..::.:.|.|
Mouse   457 EEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ--- 518

  Fly   517 GGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSS 581
                .|||.|.:..|                    |..||.        .|.|:.:||      :
Mouse   519 ----KQQQQQQQILP--------------------GDRKPL--------YHYGRGINP------A 545

  Fly   582 DSDSEPDEPNDRARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQ 646
            |..:...|..:|||     :......||....|.|  |....|:|..|..||. ||..||.
Mouse   546 DKPAWAREVEERAR-----MNKQQNSPLAKAKPSS--AGPEPPISQASPSPPG-PLSQTPP---- 598

  Fly   647 AGDRTLIMKRKLEQNINRLQKSASTSQANVTPSRRGDESNLLRDWDFDRFFPKNANGPRGSGRGS 711
                   |:|.:|.. ....||....:..:.|
Mouse   599 -------MQRPVEPQ-EGPHKSLVAHRVPLKP--------------------------------- 622

  Fly   712 PTTTASLSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKAEPSASQSIAKEQGSASGSGSG 776
              ..|.:.||..|.    |...:..:...|...|.|.......|.|||..::.::
Mouse   623 --YAAPVPRSQSLQ----DQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQ---------- 671

  Fly   777 SGSASGSGSGGSTNSPAHKRQDSDS--RLPTNFERGFRRENSDFFPLAKRYSAVFSGASASGSTA 839
            :...:..|.|.|.|.|:..|.|:::  ::|                  :|.|::.:..:.||: .
Mouse   672 NSDPTSEGPGPSPNPPSWVRPDNEAPPKVP------------------QRTSSIATALNTSGA-G 717

  Fly   840 GSPSAQALQ---RSSAVYQRNSIYSSSISSKSKENDVPGAPG--AAAAGTATASAKPG------- 892
            ||..|||::   ||::.:|   ||    ..:..|...|..||  |...|...||:.|.
Mouse   718 GSRPAQAVRARPRSNSAWQ---IY----LQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPG 775

  Fly   893 ---------------PAAATTTATK---GAAPKT---------SKSLANFHFLRPRREKTESVIV 930
                           |.|.:....:   ||:.|.         :|:....|..||.|..:....:
Mouse   776 WERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAI 840

  Fly   931 LQNAAVRAQRL---------QQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSGVGADGTG 986
            .::..:..:|.         :.:......::::..::::..|.|....|               .
Mouse   841 GEDFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEEEEEEGDGEPSEG---------------S 890

  Fly   987 LGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSS---VHSTP--SKSFIASSGSGGL 1046
            ..|||.|:..      ...|.:|...||.......|.:....   |..||  .:|.:.:..:|..
Mouse   891 RDTPGGRSDG------DTDSVSTMVVHDVEEISGTQPSYGGGTMVVQRTPEEERSLLLADSNGYT 949

  Fly  1047 GLGGGTVVGGVIISSNHSPQSTISLASSSSNSRQNSPKNSISKTRSSSSITNLLHKSASSSSANL 1111
            .|..       ::..:|||         :.||:..||.   :|...|...:..|.|:...||..:
Mouse   950 NLPD-------VVQPSHSP---------TENSKGQSPP---TKDGGSDYQSRGLVKAPGKSSFTM 995

  Fly  1112 HHLTPCSSTSSASISNPLPPHAYALQQKQRSFLTFG-FGAGGSGPS------------------- 1156
                                           |:..| :..||||.:
Mouse   996 -------------------------------FVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQF 1029

  Fly  1157 --RRESHVNVNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGK 1219
              |:.|.||||  ||:..|.::||||||||||||||||||||||||||:||||||||||||||||
Mouse  1030 DVRKGSVVNVN--PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1092

  Fly  1220 VYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGD 1284
            ||.||.|||||||:||||.|:|:|||||:|::||||||||::|||..|   .:||::.||..|||
Mouse  1093 VYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHND---PEVEKKQGWTTVGD 1154

  Fly  1285 LQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRL 1349
            ::|..|:::||||||||||||||:|:|:|||||||||||||||:|.:|.|||||||||:|:..||
Mouse  1155 MEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL 1219

  Fly  1350 KVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGR 1414
            ||||||:.||||||:||...||||:|.|.|..|.||.|:.|||::||::||||::|||||||.||
Mouse  1220 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGR 1284

  Fly  1415 VSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVF 1479
            :.|::||||||||||||||.:.||||||.|||||||||:||||||||||:|||||||||||||||
Mouse  1285 IIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1349

  Fly  1480 FSSAKGASSCQIYFMTLNKPGMANW 1504
            |:|.:...|.|:||||||:..:.||
Mouse  1350 FASVRSGGSSQVYFMTLNRNCIMNW 1374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	233/270 (86%)
		S_TKc	32..296	CDD:214567	227/263 (86%)
		CNH	1183..1484	CDD:214481	225/300 (75%)
Mink1	XP_006533740.1	STKc_MAP4K4_6_N	8..289	CDD:270806	241/280 (86%)
		PHA03307	539..>835	CDD:223039	81/396 (20%)
		CNH	1056..1354	CDD:214481	225/300 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850710
Domainoid	1	1.000	476	1.000	Domainoid score	I431
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1112	1.000	Inparanoid score	I227
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46069
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	1	1.000	-	-		FOG0001422
OrthoInspector	1	1.000	-	-		otm43111
orthoMCL	1	0.900	-	-		OOG6_101812
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X885
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770