DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and MINK1

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_006721594.1	Gene:	MINK1 / 50488	HGNCID:	17565	Length:	1361	Species:	Homo sapiens

Alignment Length:	1580	Identity:	702/1580 - (44%)
Similarity:	889/1580 - (56%)	Gaps:	308/1580 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKL 75
            |:...|||||||:||:||||||||:||||||||||||||||.||||||||||||||||||||||.
Human     4 PAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQ 68

  Fly    76 EINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYI 140
            |||:|||||:||||||||||||||||||.|||||||||:|||||||||||:|||.:|||:.||||
Human    69 EINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133

  Fly   141 CREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPE 205
            ||||||||::||::|||||||||||||||:||||||||||||||||||:||||||||||||||||
Human   134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

  Fly   206 VIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFH 270
            |||||||||||||.|||:|||||||:||||..|||||:||||||||||||.|||||||||||||.
Human   199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFI 263

  Fly   271 GFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDN 335
            .||||.|:|.|..||.||.|||..||:||||:|||||||||||||.:|::.|||..:|.||||:.
Human   264 DFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE 328

  Fly   336 DDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQE----GRLAAEQQQQHHLMAQAQAQAAAAHAAAQ 396
            :||.....||.|||:..||..||||.|.::|:    ...|.:||||.....|...:|...|...|
Human   329 EDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393

  Fly   397 AQAQLQQQQQQAAAAAAAAAHAAQQ--AQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPAR--- 456
            .|.::::|:::............:|  .|:..||.:.:..||.|:.:  .|:|.|......|
Human   394 RQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE--ERRQAEREQEYIRHRL 456

  Fly   457 -PPQRLIVVPDPPHANRP---LPPTPKCGEPAGQTPQ-QQQRNSQNNFKPSLPPRRPEPQPQTAA 516
             ..||.:.:.........   |....|..|...|:.: |:|...::.:..||..::.:.|.|
Human   457 EEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ--- 518

  Fly   517 GGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSS 581
              :..|||..|                        |..||.        .|.|:.:||      :
Human   519 --KQQQQQLLP------------------------GDRKPL--------YHYGRGMNP------A 543

  Fly   582 DSDSEPDEPNDRAR----NDGTLLASDP----PKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLP 638
            |..:...|..:|.|    .:..|..|.|    |:|               |:...|.|||. ||.
Human   544 DKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEP---------------PIPQASPGPPG-PLS 592

  Fly   639 PTPDDDDQAGDRTLIMKRKLEQNINRLQKSASTSQANVTPSRRGDESNLLRDWDFDRFFPKNANG 703
            .||.           |:|.:|..                                        .|
Human   593 QTPP-----------MQRPVEPQ----------------------------------------EG 606

  Fly   704 PRGSGRGSPTTTASLSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKAEPS---ASQSIAK 765
            |..|                |...:|..|...|        ||||. |.|:.:|:   |:...:.
Human   607 PHKS----------------LVAHRVPLKPYAA--------PVPRS-QSLQDQPTRNLAAFPASH 646

  Fly   766 EQGSASGSGSGSGSASGS-----------GSGGSTNSPAHKRQDSDS--RLPTNFERGFRRENSD 817
            :...|..:.:.:.||.|:           |.|.|.|.||..|.|:::  ::|
Human   647 DPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP------------- 698

  Fly   818 FFPLAKRYSAVFSGASASGSTAGSPSAQALQ---RSSAVYQRNSIYSSSISSKSKENDVPGAPG- 878
                 :|.|::.:..:.||: .||..|||::   ||::.:|   ||    ..:..|...|..||
Human   699 -----QRTSSIATALNTSGA-GGSRPAQAVRARPRSNSAWQ---IY----LQRRAERGTPKPPGP 750

  Fly   879 -AAAAGTATASAKPG---------PAAATTTATKGAAPKT-----------------------SK 910
             |...|...||:.|.         .:.:...|:.|..|:.                       :|
Human   751 PAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNK 815

  Fly   911 SLANFHFLRPRR--------EKTESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGG 967
            :..:.|..||.|        |:|     |..|....::........::.:..:..:::..||...
Human   816 AKPDDHRSRPGRPADFVLLKERT-----LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAE 875

  Fly   968 GGGGGGGGGSSGVGADGTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHST 1032
            |.....||.|.|   |...:.|      .|:.| :.:.:...||         |... :..|..|
Human   876 GSRDTPGGRSDG---DTDSVST------MVVHD-VEEITGTQPP---------YGGG-TMVVQRT 920

  Fly  1033 P--SKSFIASSGSGGLGLGGGTVVGGVIISSNHSPQSTISLASSSSNSR-QNSPKNSISKTRSSS 1094
            |  .::.:.:..:|...|..       ::..:|||         :.||: |:.|....|....|.
Human   921 PEEERNLLHADSNGYTNLPD-------VVQPSHSP---------TENSKGQSPPSKDGSGDYQSR 969

  Fly  1095 SITNLLHKSASSSSANLHHLTPCSSTSSASISNPLPPHAYALQQKQRSFLTFGFGAGGSGPSRRE 1159
            .:.....||:.:...:|....|..|..|..|:..:......|.|.|...             |:.
Human   970 GLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV-------------RKG 1021

  Fly  1160 SHVNVNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLI 1224
            |.||||  ||:..|.::||||||||||||||||||||||||||:||||||||||||||||||.||
Human  1022 SVVNVN--PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLI 1084

  Fly  1225 SRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDLQGAV 1289
            .|||||||:||||.|:|:|||||:|::||||||||::|||..|   .:||::.||..|||::|..
Human  1085 GRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHND---PEVEKKQGWTTVGDMEGCG 1146

  Fly  1290 HFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYG 1354
            |:::||||||||||||||.|:|:|||||||||||||||:|.:|.|||||||||:|:..|||||||
Human  1147 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYG 1211

  Fly  1355 SAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNI 1419
            |:.||||||:||...||||:|.|.|..|.||.|:.|||::||::||||::|||||||.||:.|::
Human  1212 SSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDV 1276

  Fly  1420 VLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAK 1484
            ||||||||||||||.:.||||||.|||||||||:||||||||||:||||||||||||||||:|.:
Human  1277 VLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1341

  Fly  1485 GASSCQIYFMTLNKPGMANW 1504
            ...|.|:||||||:..:.||
Human  1342 SGGSSQVYFMTLNRNCIMNW 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	233/270 (86%)
		S_TKc	32..296	CDD:214567	227/263 (86%)
		CNH	1183..1484	CDD:214481	225/300 (75%)
MINK1	XP_006721594.1	STKc_MAP4K4_6_N	8..289	CDD:270806	241/280 (86%)
		S_TKc	25..289	CDD:214567	227/263 (86%)
		CNH	1043..1341	CDD:214481	225/300 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160355
Domainoid	1	1.000	478	1.000	Domainoid score	I423
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1136	1.000	Inparanoid score	I219
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46069
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	1	1.000	-	-		FOG0001422
OrthoInspector	1	1.000	-	-		otm41041
orthoMCL	1	0.900	-	-		OOG6_101812
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X885
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770