DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msn and stk25b

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_005171260.1	Gene:	stk25b / 406600	ZFINID:	ZDB-GENE-040426-2537	Length:	430	Species:	Danio rerio

Alignment Length:	445	Identity:	163/445 - (36%)
Similarity:	244/445 - (54%)	Gaps:	54/445 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAHQQQQQLAPSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDV 65
            |||.:..|   :.|..|         ||...|...|.:|.|::|:||||.:.:|.::.|||::|:
Zfish     1 MAHLRDMQ---NQNSRL---------DPEEYFTKQERIGKGSFGEVYKGINNRTKEVVAIKIIDL 53

  Fly    66 --TEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTK 128
              .|||.|:|:.||.||.: .:...:..|||:::|.:      :||::|||.|.||..||:|.
Zfish    54 EEAEDEIEDIQQEITVLSQ-CDSPYVTKYYGSYLKGT------KLWIIMEYLGGGSALDLLKP-- 109

  Fly   129 GQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRN 193
             ..|:|.:||.|.||||:||.||||.:.||||||..||||::..:|||.||||:.||..|..:||
Zfish   110 -GPLEETYIATILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN 173

  Fly   194 TFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPP 258
            ||:|||:|||||||     ..:.||.::|:|||||||:|:|:.:||..||||||.|||||:|:||
Zfish   174 TFVGTPFWMAPEVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNTPP 233

  Fly   259 RLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEK 323
            .|:. .:||.|..|::..|.||...||..:.||||.||...........:|   |||.::.|.|.
Zfish   234 TLEG-SYSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSYLTEL---IDRYRRWKSEG 294

  Fly   324 ERED--------YRYSGSDNDDDEPQLAGEHSSIVQAPGGDTLR-RNFQQIQEGRLAAEQQQQHH 379
            ..::        |.....|.|.|:    .:|..:...|   |:| .:..::|:|....:.:....
Zfish   295 HGDESSSDDSDMYAVHPLDGDGDD----RDHCPVWTFP---TVRPSSMNKLQKGYTNTDSEAAET 352

  Fly   380 LMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQP 434
            :..|.::|..:|     ..:.:.::.::...|......|.::.:.|...|:...|
Zfish   353 VKRQPKSQCLSA-----LVSPIFRELKEKRRACGGGMGAIEELENAFNLAEESCP 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	131/272 (48%)
		S_TKc	32..296	CDD:214567	129/265 (49%)
		CNH	1183..1484	CDD:214481
stk25b	XP_005171260.1	STKc_MST3_like	20..291	CDD:270786	135/289 (47%)
stk25b	XP_005171260.1	S_TKc	20..270	CDD:214567	129/265 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910