DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and Tao

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster

Alignment Length:	1053	Identity:	264/1053 - (25%)
Similarity:	401/1053 - (38%)	Gaps:	289/1053 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SLDD---IDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVT----EDEEEEI 73
            ||.|   .||....||..|||.:..:|:|::|.||..|...|.::.|||.|..|    :::.::|
  Fly     8 SLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDI 72

  Fly    74 KLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIA 138
            ..||..|::. ||.|...|.|.::::|      ..||||||| .||.:|:::..| :.|.|:.||
  Fly    73 LKEIRFLRQL-NHPNTIEYKGCYLRES------TAWLVMEYC-VGSASDIIEVHK-KPLHEDEIA 128

  Fly   139 YICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMA 203
            .||..:|.|||||||...||||||..|:|||||..|||.||| ||.:...   .|:|:|||||||
  Fly   129 AICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFG-SAAIKCP---ANSFVGTPYWMA 189

  Fly   204 PEVI-ACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSK 267
            |||| |.||   ..||.:.|:||||||.:|:||.:||..:::.|.||:.|.:|..|.|....||.
  Fly   190 PEVILAMDE---GQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSD 251

  Fly   268 KFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYR--- 329
            .|..|::..|.|...:||.:..||.|.:: .:|....|.::|   |.|.|...:|.:..:||
  Fly   252 AFCSFVELCLKKMPAERPSSAKLLTHAYV-TRPRSDTVLLEL---IARTKSAVRELDNLNYRKMK 312

  Fly   330 -----------YSGSDNDDDEPQLAG-----------EHSSIVQAPGGDTLRRNFQQIQEGRLAA 372
                       .:..|.||.:...||           |||  :.:.|  ....:.|......:.|
  Fly   313 KILMVDTCETESAVGDTDDQQDDHAGGDSSKSNSITSEHS--IHSVG--VSAASSQSSSSNSIPA 373

  Fly   373 EQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQAN 437
            ..|..||:         |||          ..||.|:||.|||.|......|
  Fly   374 AAQNHHHI---------AAH----------HHQQAASAAVAAAMHHHHHPHQ------------- 406

  Fly   438 RQPKP--PSRQQVE--EPGPPARPPQRLIVVPDPPHANRPLPPTPKCGEPAGQTPQQQQRNSQNN 498
             ||.|  ||.||.:  .||..:|...|        |.||  ||.|..            .:|.||
  Fly   407 -QPPPSWPSGQQGQPVPPGAVSRNSSR--------HRNR--PPLPNI------------MHSMNN 448

  Fly   499 FKPSLPPRR-----PEPQPQTAAGGQGSQQQAQPEAPP----RNNRQSSGLSSSGGSASGGGGSS 554
               ::.|..     |.|.|             .|..||    ..:..:.|....||:.:||.|..
  Fly   449 ---NVTPTNSASVVPAPAP-------------APVLPPPISVLPHLSAMGHVGGGGTGTGGSGGG 497

  Fly   555 KPAAALPQQSNNHLGQPVNPLDP---------------LDSSDSDSEPDEPNDRARNDGTLLASD 604
            .||:..|      |...:.|:.|               ..:|...:..:..||...|:...:
  Fly   498 SPASGGP------LADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATI--- 553

  Fly   605 PPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQAGDRTLIMKRKLEQNINRLQKSA 669
                           .||:.::..........:     .:..:|.:.  |:|:.:.::.:|::..
  Fly   554 ---------------RTTSIVTKQQKEHMQEEM-----HEQMSGYKR--MRREHQAHLVKLEEKC 596

  Fly   670 STSQANVTPSRRGDESNLLRDW--DFDRFFPKNANGPRGSGRGSPTTTASLSRSSQLSTLKVDT- 731
            .........:...:...||.::  |.||...|:.....   |.:..|:|:..:..:..|||.:.
  Fly   597 KVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVE---RRAKQTSAAEKKLHKEITLKQEND 658

  Fly   732 ----KLQRASVAEAITRPVPRGYQPLKAEPSASQSIAKEQGSASGSGSGSGSASGSGSGGSTNSP 792
                .|.|....:|       ..:..|.|.|..:|..|.|...:....            ..|..
  Fly   659 RKVYDLNRKKEYKA-------NKERWKRELSMDESTPKRQRDLTLQSQ------------KDNLK 704

  Fly   793 AHKRQDSDSRLPTNFE------RGFRRENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRSS 851
            .|:.|:....|....:      |.|:|         ||....................|.||::.
  Fly   705 QHEAQEEQRMLQAQKQYIELEMRKFKR---------KRMIMQHEHEDQQLRDELGKKEQQLQQAH 760

  Fly   852 AVY-------------QRNSIYSSSISSKSKENDVPGAPGAAAAGTATASAKPGPAAATTTATKG 903
            |:.             |:.|::.......:|::|                       ......|.
  Fly   761 AMLLKHHEKTQELEYRQQKSVHQLREEQINKQHD-----------------------TELHNQKD 802

  Fly   904 AAPKTSKSLANFHFLRPRRE-------------------KTESVIVLQNAAVRAQRLQQLQQQQQ 949
            ...:..|.|...|.:..|::                   ||::   .|....:||.||...::||
  Fly   803 YMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQT---KQYKRYKAQVLQTTPKEQQ 864

  Fly   950 QQQLQQQQQQQNR 962
            ::.::|.:::::|
  Fly   865 KEVIKQLKEEKHR 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	120/275 (44%)
		S_TKc	32..296	CDD:214567	117/268 (44%)
		CNH	1183..1484	CDD:214481
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	118/273 (43%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	117/268 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940