DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and Nrk

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_038955641.1	Gene:	Nrk / 315907	RGDID:	1566163	Length:	1471	Species:	Rattus norvegicus

Alignment Length:	1645	Identity:	480/1645 - (29%)
Similarity:	715/1645 - (43%)	Gaps:	364/1645 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTE------------------ 67
            ||..|.||.|||.|.:.:|.||||::|.|.|.|||...|||||:..:
  Rat    14 DLGHLPDPTGIFSLEKTIGLGTYGRIYLGLHEKTGSFVAIKVMNARKTPLPEIGKRVRVNKYRKS 78

  Fly    68 ------DEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKS 126
                  ||||:::.|:|:|:|||.|:||.|:||||.|.:|||...|||:|||.|.||||||:|:.
  Rat    79 VGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGAFFKLNPPGHQHQLWMVMELCAAGSVTDVVRM 143

  Fly   127 TKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGR 191
            |:.|||||:||||||||||:||::||:::||||||||||||||.:||||:||||||||:.||.||
  Rat   144 TRNQSLKEDWIAYICREILQGLAHLHAHQVIHRDIKGQNVLLTQDAEVKIVDFGVSAQVSRTNGR 208

  Fly   192 RNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS 256
            ||:|||||||||||||.|||:|..:||.|||:||:||||:||||..||||:|.|:.|||:|.|.:
  Rat   209 RNSFIGTPYWMAPEVIHCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILREA 273

  Fly   257 PPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDH---IDRCKK 318
            .|.:||..||:||..|::..::|::..||.:.|:|.|.|:.|...:|:|...|..|   |.:.::
  Rat   274 APTVKSSGWSRKFQNFMENCMIKNFLFRPTSGNMLHHPFVHDIKNERRVVESLTKHLTGIIQKRE 338

  Fly   319 RK--------QEKEREDY---RYSGSDNDDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQEGRLAA 372
            ||        :|...|.|   |:.|       |....|   :::.|.....|.  .::..|
  Rat   339 RKGIPLAFEGEEAVNEQYITRRFRG-------PSCTPE---LLRVPTSSRCRP--LRVLHG---- 387

  Fly   373 EQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQAN 437
            |..|...|..:.|.:          ..:|||.|:  ||......|:..:..:..|: |||.|| :
  Rat   388 EPPQPRWLPDEEQPE----------DQELQQLQE--AARMFMPLHSQDKTLKPLQK-QAQLPQ-H 438

  Fly   438 RQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHANRPL-----PPTP--KCGEPAGQTPQQQQRNS 495
            ....|.....|:.....|.|..:.|..  ||..::..     ||:.  |...|..|.|..:::.:
  Rat   439 LHVAPQVLMPVQVEATVATPLAKKIRA--PPQLSKAAWGLTSPPSQDNKASSPEVQAPIPREQQA 501

  Fly   496 QNNFKPSLPP--------------RRPEPQPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGS 546
            ||:...:..|              |..|.|.|..|..|..:|...||..|..||:..       .
  Rat   502 QNDALETEQPEDLDQVPEEFQGQDRAAEEQRQGQAAEQEQRQNGVPEQHPEENREPE-------Q 559

  Fly   547 ASGGGGSSKPAAA-----------------LPQQSNNH-----LGQPVNPLDPLDSSDSDSEPDE 589
            |.....:.:|..|                 ||.||.||     |......|.|:...:.::...:
  Rat   560 AEVQEEAVEPPQAEVEEKDPEVIQVHARVFLPLQSQNHHVFLPLHLDTQLLIPVGEQNEEAPRAQ 624

  Fly   590 PND--RARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPP------------- 639
            ..|  .:|..|.:.|.     :.||   |.|      |........::||.|
  Rat   625 AWDLEASRAAGAVQAL-----VEGL---SRD------LLRAPNAFTSKPLGPLQILLESLCTNGF 675

  Fly   640 --TPDDDDQAGDRTLIMKRKLEQNINRLQKSASTSQA----------NVTPSRRGDESNLLRDWD 692
              .|:...:...|...:|:.:   :.||......::|          :|..|||..:    |.|:
  Rat   676 YTEPEAVQKKKSRVSSLKKAI---VKRLTPKRFRAKALWRRQDFECSDVESSRRRRQ----RRWE 733

  Fly   693 --FDRFFPKNANGPRGSGRGSPTTTASLSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKA 755
              |::                        ...||..::.|.....:|..:.:...:....|   .
  Rat   734 EIFNQ------------------------HEEQLREVENDRDDDDSSDNDEVFHSIQAEVQ---I 771

  Fly   756 EPSASQSIAKEQGSASGSGSGSGSASGSGSGGSTNSPAHKRQDSDSRLPTNFERGFR-------- 812
            ||.|                             .|...::.|:..:.:|.|..|..|
  Rat   772 EPYA-----------------------------PNRTGNEVQERSAPMPCNRNRTHRVKFSPSVC 807

  Fly   813 --------RENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRSSAVY----QRNSIYSSSIS 865
                    ::..|..|........|...|.|.|...||..:...:||..|    ||..|
  Rat   808 EQALLEEAQQPMDIRPRNSLNPRNFQAESESSSEEDSPVTRRKSQSSPPYSTIDQRLLI------ 866

  Fly   866 SKSKENDVPGAPGAAAAGTATASAKPGPAAATTTATKGAAPKTSKSLANFHFLRP---RREKTES 927
                  |: ..|.....|      |..|....|....|..|.:.....::....|   |.|:...
  Rat   867 ------DI-HVPDGFKVG------KISPPVYLTNEWVGCNPLSEVFWDDWVNPTPATRRHEEDGD 918

  Fly   928 VIVLQNAAVRAQ-RLQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSGVGADGTGLGTPG 991
            .:.|.:|..... |......::...........|..|..|.|......|.....| |..|....|
  Rat   919 YVELYDADANGDGRASNYAYEENYASGHDDMNHQANGYRGHGNRHYSDGSFRNRG-DSRGAAFNG 982

  Fly   992 TRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHSTPSKSFIASSGSGGLGL--GGGTVV 1054
            .|.|.....:|..|                                    |:.|..|  |.....
  Rat   983 PRASYCRGGILKNA------------------------------------GNDGRDLRRGAFRAY 1011

  Fly  1055 GGVIISSNHSPQSTISLASSSSNSRQ----NSPKNSISKTRSSSSITNLLHKSASSSSANLHHLT 1115
            |....|:.|...|..|.|..|....:    ....|...:...||............:..:..|:.
  Rat  1012 GDNEASNYHGAASGASAAFGSQEGHEGHMGGRRGNRYREVNGSSGENGACGFHRDGAGLDQQHVF 1076

  Fly  1116 P----------CSSTSSASISNPLPPHAYAL---QQKQRSFLTFGFGAGGSGPSRRESHVNVNVT 1167
            |          ..:.:|.||:  |...:::|   |...|:..|.||      |.||.|
  Rat  1077 PDFENEQEQSDAGTETSDSIA--LEITSFSLDGEQNNDRAEPTLGF------PLRRSS------- 1126

  Fly  1168 PTSHEAANDT---------PEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQL 1223
              |..:|:||         |.|..|::.|:.||.|.:|||||||:||::.|.|:||||:.::.:|
  Rat  1127 --SRGSASDTDIMSDSYNKPIIHAYEREFSHEIFCGSLWGVNLLLGTKSHLYLMDRSGKAEIIKL 1189

  Fly  1224 ISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQ-----VERRNGWINVG 1283
            :.||.|:|::|:|..|:|:||||:|||:|||:|:||::|||..|..|.:     ::|.....::.
  Rat  1190 VKRRPFRQIQVVEQLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKKRQKAMLKREKACKSLD 1254

  Fly  1284 DLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSR 1348
            .|.|..||.|:.:|...::.||||.||.:||||||.:::..|.|.|...:.:|:.|||.:..:..
  Rat  1255 KLIGCEHFSILHHEETTYIAIALKSSIHLYAWAPKSFNESTAIKVFPTHDLKPVTVDLAVGSEKT 1319

  Fly  1349 LKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVG 1413
            ||:.:.||.|:|.:|.:|..:.|:.||.:.        ::.||:|.|:.::|.:::|........
  Rat  1320 LKIFFSSANGYHIIDAESEVMSDVTLPSNN--------VILLPDSLGVGVMLSFNDETAPEEANE 1376

  Fly  1414 RVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKV 1478
            ::.|.|:..|.::|:|.|:..|.:|.||..||:|:||:::..|:.....:..::|:|||.|.||:
  Rat  1377 QLLKKILDVWKDIPSSAAFECTQRITGWDQKAVEVRSLQATILENELKRRSIKKLRFLCSRGDKL 1441

  Fly  1479 FFSSAKGASSCQIYFMTLNK 1498
            ||:|........:|::::.|
  Rat  1442 FFASLLNNEHSLVYYVSIAK 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	168/294 (57%)
		S_TKc	32..296	CDD:214567	163/287 (57%)
		CNH	1183..1484	CDD:214481	116/305 (38%)
Nrk	XP_038955641.1	PKc_like	18..313	CDD:419665	168/294 (57%)
Nrk	XP_038955641.1	CNH	1158..1438	CDD:395630	106/287 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920