DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and nak1

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	NP_596023.1	Gene:	nak1 / 2539963	PomBaseID:	SPBC17F3.02	Length:	652	Species:	Schizosaccharomyces pombe

Alignment Length:	681	Identity:	187/681 - (27%)
Similarity:	282/681 - (41%)	Gaps:	147/681 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IEVVGNGTYGQVYKGRHTKTGQLAAIKV--MDVTEDEEEEIKLEINVLK--KYSNHRNIATYYGA 95
            :|:||.|:||.||:|....|.:..|||:  :|..|||..:|:.|:.||.  |.|:..||..|:|:
pombe    13 LELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVENIIKYHGS 77

  Fly    96 FIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRD 160
            ::..:      .||::|:||..|||..|:::   ..:.|..|:.|.||.|:.|.::|...:||||
pombe    78 YLVGT------NLWIIMDYCHGGSVRTLMEA---GPISEPCISLILRETLQALKFIHHAGIIHRD 133

  Fly   161 IKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWS 225
            ||..|:|::.:..|||.||||:|:|:....:|.||||||||||||||...:.    |:..:|:||
pombe   134 IKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQE----YNVMADIWS 194

  Fly   226 LGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENL 290
            |||||.|:|...||.....|.||::||...:||||.. .:|.....||.:.|.....:|..:..|
pombe   195 LGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRLNG-NFSALLKEFIASCLQDVPQRRLDSSEL 258

  Fly   291 LKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEPQLAGEHSSIVQAPGG 355
            ||..|||     :..|:.:.:..:..|           ||                 ...||.||
pombe   259 LKSKFIK-----QYSRMSISELTNVVK-----------RY-----------------DTWQAAGG 290

  Fly   356 DTLRRNFQQIQEGRLAAEQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAAAAAAAHAAQ 420
                     |.:..|..|:........|..:..||:....:. ..::|.|...::....:.....
pombe   291 ---------IPQTLLLGEEADDGSDPDQETSDTAASDDGWEF-GTIKQGQSNVSSITGTSTSTTT 345

  Fly   421 QAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQRL-----IVVPDPPHANRPLPPTPKC 480
            .|..:........|:::...:|||...       :.|..:|     |...|.|............
pombe   346 AATSSTTVTGTVIPKSSTVHEPPSSND-------SHPLLQLFKDSKISDDDSPSNAEGASTEDSK 403

  Fly   481 GEPAGQTPQQQQRNSQN-NFKPSLPPRRPEPQPQ--------TAAGGQGSQQQAQPEAPPR-NNR 535
            ||.:....:....:|.| :.|.|....:...|.:        |.:..:.|..|:.....|| ..|
pombe   404 GEVSYSQIELPSLDSSNLSSKKSTIQSKHTKQAEDYDLFVGRTRSNSKTSSDQSIKRPLPRVVQR 468

  Fly   536 QSSGLSSSGGSASGGGGSSKPAAALP---------------QQSNNHLGQPVNP----LDPLDSS 581
            |.:.|...|.|.|    ..||...:|               :|.:..|..|.:.    |.||:.:
pombe   469 QKTSLGKRGISMS----PMKPGLRMPSSFDLQSRSISMGAFEQLSTPLEAPAHKHSAVLQPLEVN 529

  Fly   582 DSDSEPDEPNDRARNDGTLLASDPPKPL-PGL--GPVSEDANTTTPLSHGSGGPPNRP------- 636
            .|.|.|                 |||.: |.:  .|..|.|::|..:|..|..|  :|
pombe   530 RSISIP-----------------PPKSISPSILHKPSLESASSTPKISSCSSTP--KPFNSKLRA 575

  Fly   637 -LPP----TP-------DDDDQAGDRTLIMK 655
             |||    :|       |:.|..|.|.|.|:
pombe   576 HLPPLSIGSPAVQPLANDNYDSLGVRGLNME 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	106/264 (40%)
		S_TKc	32..296	CDD:214567	106/264 (40%)
		CNH	1183..1484	CDD:214481
nak1	NP_596023.1	PKc_like	8..282	CDD:304357	111/298 (37%)
nak1	NP_596023.1	S_TKc	10..264	CDD:214567	106/264 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910