Protein Alignment msn and rgf3

DIOPT Version :10

• Sequence 1: NP_524679.3
• Gene: msn / 44030
• FlyBaseID: FBgn0010909
• Length: 1504
• Species: Drosophila melanogaster
• Sequence 2: NP_588115.1
• Gene: rgf3 / 2539437
• PomBaseID: SPCC645.06C
• Length: 1275
• Species: Schizosaccharomyces pombe
• Alignment Length: 1338
• Identity: 253/1338 - (18%)
• Similarity: 402/1338 - (30%)
• Gaps: 456/1338 - (34%)

  Fly   467 PPHANRPLPPTPKCGEPAGQ--------------TP---QQQQRNSQNNFKPSLPPRRP------ 508
            |||::.|         |:.|              :|   .::..||.:.|..| ||:.|
pombe    31 PPHSSSP---------PSFQKRLSFSDFSTTRLFSPPFLSKRSNNSPHRFSYS-PPQHPASINSR 85

  Fly   509 ---------------------EPQPQTAAGGQGSQQQAQ-PEAPPRNNRQSSGLSSSGGSASGGG 551
                                 |||...|.....|...|. .:..|.|...:....:|.|:.....
pombe    86 RVASYTVQSSPSRTTYRQLPNEPQNSAAYTTYSSFPNALFDDFSPNNPLDTDPFLTSPGNKQNTV 150

  Fly   552 GSSKPAAALPQQSNNHLGQPVNPLDPLDSS-DSDSEPDEPNDRAR-----NDGTLLASDPPKPLP 610
            .|.:|....|......|..|: |..||.|| .|.|.|........     ||.:|..|  |:|..
pombe   151 DSFRPLPETPVSPGGSLVHPL-PRPPLPSSVSSHSSPYSTTSSTSLYSLYNDISLSCS--PEPYL 212

  Fly   611 GLGPVSEDANTTTPLSHGSGG----------------PPN-----------RPLPPTPDDDDQAG 648
            .|.|....|.|.:|:...|..                |||           |.||..|..|..:|
pombe   213 PLSPTRSPARTPSPIRLYSSDALRPQSPLSPSVEYLTPPNPYSLKSDISSTRQLPKIPVQDYASG 277

  Fly   649 ---------------DRTLIMKRKLEQNINRLQK-------SASTSQANVTPSRRG--------- 682
                           ..||....:....:.:|.|       :|.....:...|||.
pombe   278 KISSPLITRTHRRAQSETLFSSCREPWLVGKLYKWCKEEVFTALGGLVHEGVSRREVAQVMATLF 342

  Fly   683 --------------DESNLLRDW---------DFDRF---FPKNANGPRGSGRGSPTTTASLSRS 721
                          ...|:|.||         :.::.   |..| ..|.|||     ....|:..
pombe   343 TIHIASMEFLIAEIIAKNILGDWINYGLVEVINLEKLQIAFTSN-EPPSGSG-----VLPFLTNG 401

  Fly   722 SQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKAEPSASQSIAKEQGSASGSGSGSGSASGSGSG 786
            ...|.:             ..:|..|..||......:.:.|:  |..|..|..|.:.|...:.|
pombe   402 GCYSYI-------------CRSRSCPSKYQCYSCRCARNSSL--EFTSLPGQSSDTWSIFWNIS- 450

  Fly   787 GSTNSPAHKRQDSDSRLPTNF-ERGFRRENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRS 850
             |.||           ||::. :|...|:|:....:.|.          |...|...:...|.|.
pombe   451 -SLNS-----------LPSSLSKREIARQNNIHELICKE----------SDYVADLNTLAELFRD 493

  Fly   851 SAVYQRNSIYSSS----------------------------ISSKSKENDVPGAPG-------AA 880
            ..|.|:::|..|:                            |..:..:..|....|       .|
pombe   494 GIVQQQDAIVPSNRVADFIQSVFGNVESIRQLHSRLFLPQLIMRERLQGPVVSIIGDILLEWIHA 558

  Fly   881 AAGTATASAKPGPAAATTTATKGAAPKTSKSLANFHFLR--------PRREKTESVIVLQNAAVR 937
            |..:....||..|.|..|...        :...|.:|.|        ||..:.:....||....|
pombe   559 AKSSYINYAKQFPLADETYKL--------ECQRNTYFARWLAACRSDPRCRRLDFQHFLQRPTQR 615

  Fly   938 AQR--------LQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSGVGAD---GTGL---- 987
            .||        |:..:|.....||..|..::.|              ::....|   .|.|
pombe   616 LQRYTLELDTILKHTEQSSWDFQLITQAVKELR--------------ATCEECDAVIATVLEANR 666

  Fly   988 ------------------------------GTPGTRTSS----------VLPDLLSQASPATPPR 1012
                                          |....|:.|          :|.:.|..|.    .|
pombe   667 IRDLSYQLLFKNHESVNLELRDPEREFFFEGIVQRRSDSRLDWLDIHLFLLDNYLIMAK----AR 727

  Fly  1013 HDK-SSSEEYQAA-----ISSSVHSTPSKSF-IASSGSGGLG-LGGGTVVGGVIISSNHSPQSTI 1069
            .|| :::..|..:     :...|.|.....| :.|:.:..|| |.|......:...|....:..:
pombe   728 KDKRTNASRYVVSKRPIPLDLLVLSPKMDDFQLKSNTNKFLGSLAGNLPQESLTTKSKRKSKVNL 792

  Fly  1070 SLA--SSSSNSRQNSPKNSISKTRSSSSITNLLHKSASSSSANLH--------------HLTPCS 1118
            .|.  :::..:.:||..:::.:.......| :.|..|.::|..|:              ::....
pombe   793 ELMFDATAEKNNENSMNSAVFEKSQLYPFT-IRHLGAYTASYTLYVESLQLRKLWVEKINVAKKR 856

  Fly  1119 STSSASISNPLPPHAYALQQKQRSFLTFGFG----AGGSGPSRRESHVNVNVTPTSHEAANDT-- 1177
            .:...:|.||     :||  |..|.:.|.:.    ..|:.|....:.:.:....:...|.|:.
pombe   857 HSQKINIKNP-----FAL--KVVSDVAFQYPPSDLVNGNEPLNSFNEITLVEGSSIDRALNEVAW 914

  Fly  1178 ----------PEIRKYKKRFNSEILCAALWG-----VNLLIGTENGLML---LDRSGQGKVYQLI 1224
                      ||...|     .:|.|.|.:.     |::||.|..|:.|   .|.|......::.
pombe   915 KHPIVSEELLPEPIAY-----GDISCIAQFNDYEGHVSVLIATSTGIFLGAFGDSSDIRDWKKIS 974

  Fly  1225 SRRRFQQMEVLEGQNILVTISGK----KNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDL 1285
            |:||..|:.|:|..:||:.:..|    ....|:..:..::|||....|....|    .:..:|.|
pombe   975 SQRRVTQLGVVEEFDILLELRDKTLYAHKLSRIIEMGLIESKIAVVIGTPHAV----SFFKIGKL 1035

  Fly  1286 -QGAVHFKIVKYER-IKFLVIALKDSIEIYAWAP-----KPYHKFMAFKNFGELEHRPLLVDLTI 1343
             :||    .||.|| :.|....|.::..|....|     ..|.|..|||.......|      |:
pombe  1036 SEGA----SVKRERTLVFYKEGLGNTTTIICCEPVIGLGHNYQKTYAFKRKDVTSFR------TL 1090

  Fly  1344 EDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAII----PHCIVALPNSNGMQLLL---- 1400
            :|       :......|::|...   |.|.| .|.:|..:    |...|..|:.:.:...|
pombe  1091 DD-------FHVTANCHSIDCFK---YSIAL-CHNKGIDVLRLDPKLAVGFPSPSVLNDTLFRNR 1144

  Fly  1401 --------------------CYDNEGVYVNTVG-RVSKNIVLQWGEMPTSVAYIGTGQIMGWGNK 1444
                                ||....|:||..| .|:|.....|...|.||... .|.::.:.::
pombe  1145 INNSKPLGVFRIHDPSLFACCYQFGAVFVNGEGSMVNKECWFDWIGKPNSVTSC-HGYLIAFNDE 1208

  Fly  1445 AIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSS 1482
            .:||            .:.:.::|..:.:.||..::.|
pombe  1209 FVEI------------WNTRTRKLNQIIQGNDIKYYPS 1234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785
		CNH	1183..1484	CDD:214481	77/348 (22%)
rgf3	NP_588115.1	ROM1	<392..1247	CDD:227709	179/963 (19%)
		CNH	944..1235	CDD:459938	73/329 (22%)