DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and NRK

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	NP_940867.2	Gene:	NRK / 203447	HGNCID:	25391	Length:	1582	Species:	Homo sapiens

Alignment Length:	1741	Identity:	504/1741 - (28%)
Similarity:	740/1741 - (42%)	Gaps:	445/1741 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTE------------------ 67
            ||..|.||.|||.|.:.:|.||||::|.|.|.|||...|:|||:..:
Human    14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKS 78

  Fly    68 ------DEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKS 126
                  ||||:::.|:|:|:|||.|:||.::||||.|.||||:..|||:|||.|.||||||:|:.
Human    79 VGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRM 143

  Fly   127 TKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGR 191
            |..|||||:||||||||||:||::||:::||||||||||||||.||||||||||||||:.||.||
Human   144 TSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGR 208

  Fly   192 RNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS 256
            ||:|||||||||||||.|||:|..:||.|||:||:||||:||||..||||:|.|:.|||:|.|.|
Human   209 RNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRES 273

  Fly   257 PPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQ 321
            .|.:||..||:|||.|::...:|::..||.:.|:|:|.|::|...:|.|...|..|:....|::|
Human   274 APTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQ 338

  Fly   322 EK------ERED--------YRYSGSD------------------------------NDDDEPQL 342
            :|      |||:        .|:.|..                              .|.:|||
Human   339 KKGIPLIFEREEAIKEQYTVRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQ- 402

  Fly   343 AGEHSSIVQAPGGDTLRRNFQQIQEGR-----LAAEQQQQHHLMAQAQAQ-----AAAAHAAAQA 397
                   |||         .||:|...     |.|.......|..||||.     ||......||
Human   403 -------VQA---------LQQLQGAARVFMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQA 451

  Fly   398 QAQLQ-----QQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARP 457
            |.:.:     |.|.:|......||......|...:..:..|.|:....|..::.|..|
Human   452 QVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSE------- 509

  Fly   458 PQRLIVVPDPPHANRPLPPTPKCGEPAGQTPQQQQRNSQ---NNFKPSLPPRRPEPQPQTAAGGQ 519
            ||.|..||:.......:|...:    .||.|:||||::|   ...:.:..|.:||.|.|.|...|
Human   510 PQDLDQVPEEFQGQDQVPEQQR----QGQAPEQQQRHNQVPEQELEQNQAPEQPEVQEQAAEPAQ 570

  Fly   520 GSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSSDSD 584
            ...:..:||: .|.|.|                     ..||..|.:|     :.|.||......
Human   571 AETEAEEPES-LRVNAQ---------------------VFLPLLSQDH-----HVLLPLHLDTQV 608

  Fly   585 SEPDEPNDRARNDGTLLASDPPKPLPGLGPVSEDAN---TTTPLSHGSGGPPNRPLPPTP----- 641
            ..|.|..............:||:.:..:..:.|..:   ...|.|:.|     :||.|..
Human   609 LIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNS-----KPLGPLQTLMEN 668

  Fly   642 -------DDDDQAGDRTLIMKRKLEQNINRLQKSASTSQANVTPSRRGDESNL------------ 687
                   ...:||.::    |.|:......|.|..|..:.....|.|.::..|
Human   669 LSSNRFYSQPEQAREK----KSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQRRQR 729

  Fly   688 ------------LRDWDFDRFFPKNANG-------------PRGSGRGSPTTTASLSRSSQLST- 726
                        ||..|.|:....:.|.             |......:|.......||..:..
Human   730 RWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPKKIEVQERSPSVPNN 794

  Fly   727 ------LKVDTKLQRASVAEAITRPV---PRGYQPLKAEPSASQSIAKEQGSASGSGSGSGSASG 782
                  :|..:.:.:.|:.|...:|:   .|..|..:...:||:|.::|:...:|..|.|
Human   795 QDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQS----- 854

  Fly   783 SGSGGSTNSPAHKRQDS----DSRLPTNFERG---------------------FR---------- 812
                    ||.:...|.    |..:|..|:.|                     ||
Human   855 --------SPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIFRNDWLTPAPVI 911

  Fly   813 ---RENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRSSAVYQR--------NSIYSSSISS 866
               .|:.|:..|          ..||..|.|....::.......|..        |.:..::...
Human   912 QPPEEDGDYVEL----------YDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVDQANDVC 966

  Fly   867 KSKEND--------------VPGAPGAAAA--GTATASAKPGPAAATTTATKGAAPKTSKSLANF 915
            |..::|              .|..|.|:..  |:.......| :.....|.:|....|:
Human   967 KDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDG-SRGKEEAYRGYGSHTA------ 1024

  Fly   916 HFLRPRREKTESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSGV 980
                 .|....|.....|||:.                .|::...|.|....|..|.||.|....
Human  1025 -----NRSHGGSAASEDNAAIG----------------DQEEHAANIGSERRGSEGDGGKGVVRT 1068

  Fly   981 GADGTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHSTPSKSFIASSGSGG 1045
            ..:...||..|.          ...|....|...:.:|::::              ::.....||
Human  1069 SEESGALGLNGE----------ENCSETDGPGLKRPASQDFE--------------YLQEEPGGG 1109

  Fly  1046 LGLGGGTVVGGVIISSNHSPQSTISLASSSSNSRQNSPKNSISKTRSSSSITNLLHKSASSSSAN 1110
                            |.:..:..|.|:.|:...::..|:              :.:|::.|..:
Human  1110 ----------------NEASNAIDSGAAPSAPDHESDNKD--------------ISESSTQSDFS 1144

  Fly  1111 LHHLTPCSSTSSASISNPLPPHAYALQQKQRSFLTFGFGAGGSGPSRRESHVNVNVTPTSHEAAN 1175
            .:|.:|...:..::.:|......||           ||........::.|.||||  |.....|.
Human  1145 ANHSSPSKGSGMSADANFASAILYA-----------GFVEVPEESPKQPSEVNVN--PLYVSPAC 1196

  Fly  1176 DTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNI 1240
            ..|.|..|:|.|.|||.|.:|||||||:||.:.|.|:||||:..:.:||.||.|:|::|||..|:
Human  1197 KKPLIHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNL 1261

  Fly  1241 LVTISGKKNRVRVYYLSWLKSKILRTDGLS-----DQVERRNGWINVGDLQGAVHFKIVKYERIK 1300
            |:||||.|||:|||:|:||::|||..|..|     :.::.......:..|.|..||.::::|...
Human  1262 LITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETT 1326

  Fly  1301 FLVIALKDSIEIYAWAPK---------------------------------------PYHKF--- 1323
            ::.||||.||.:||||||                                       |.::|
Human  1327 YIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRP 1391

  Fly  1324 ------MAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAI 1382
                  :..|.|..|:|:|:.|||.|..:.|||:.:.||:|:|.:|.:|..:.|:.|||:....|
Human  1392 DELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456

  Fly  1383 IPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIE 1447
            ||..|:.||:..|:.::|.::.|.:.|....::.|.|:..|.::|:|:|:..|.:..|||.||||
Human  1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIE 1521

  Fly  1448 IRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTLNK 1498
            :||::|..|:.....:..::|:|||.|.||:||:|.......::|||||.|
Human  1522 VRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	171/294 (58%)
		S_TKc	32..296	CDD:214567	166/287 (58%)
		CNH	1183..1484	CDD:214481	130/353 (37%)
NRK	NP_940867.2	PKc_like	18..313	CDD:304357	171/294 (58%)
		S_TKc	25..313	CDD:214567	166/287 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..579		26/97 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..859		17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	926..1156		46/311 (15%)
		CNH	1213..1549	CDD:295303	118/335 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920