Protein Alignment msn and mig-15

DIOPT Version :10

• Sequence 1: NP_524679.3
• Gene: msn / 44030
• FlyBaseID: FBgn0010909
• Length: 1504
• Species: Drosophila melanogaster
• Sequence 2: NP_001024973.1
• Gene: mig-15 / 181248
• WormBaseID: WBGene00003247
• Length: 1096
• Species: Caenorhabditis elegans
• Alignment Length: 1531
• Identity: 655/1531 - (42%)
• Similarity: 803/1531 - (52%)
• Gaps: 483/1531 - (31%)

  Fly    17 LDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLK 81
            ||:|||.:|:|||||||||||||||||||||||||.||.||||||:|::.||||:|||||||:||
 Worm     6 LDEIDLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLK 70

  Fly    82 KYSNHRNIATYYGAFIKKSP--PGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREI 144
            |:|:|||:||||||||||.|  .||.||||||||:||:||:|||||:|||.||||||||||||||
 Worm    71 KHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREI 135

  Fly   145 LRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIAC 209
            ||||.:||.:||||||||||||||||:|||||||||||||||:|:||||||||||||||||||||
 Worm   136 LRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIAC 200

  Fly   210 DENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLK-SKKWSKKFHGFI 273
            ||:|:||||:||||||||||||||||..|||||:||||||||||||.||:|| :|||:|||..||
 Worm   201 DESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFI 265

  Fly   274 DTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDD 338
            :|||||||||||||..||:|.|||:||.::.:|..:|:||||  .|:.:|:..||.||||::|:.
 Worm   266 ETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDR--NRRVKKDDADYEYSGSEDDEP 328

  Fly   339 EPQLAG---------EHSSIVQAPGGDTLRRNFQQIQEGRLAAEQQQQHHLMAQAQAQAAAAHAA 394
            .|...|         |.||::  |..:|||:.||::||....         .|:..||.......
 Worm   329 SPNNRGPSMGIRDDSESSSMI--PMDNTLRKGFQKLQESSRG---------FAEPGAQQLRRLPQ 382

  Fly   395 AQAQAQLQQQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQ 459
            ..|.|..|.||.:.......::....:|..:...|...:.....:|:|.|..|        |.||
 Worm   383 QPAPAPFQYQQSRYVEPRRESSEVKLRAVSSRGAADGPRHSPASRPRPVSHHQ--------RSPQ 439

  Fly   460 RLIVVPDPPH----ANRPLPPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPE---PQPQTAAG 517
            :  ..|..||    ||.         |...::.::::|..:.....::|..|..   |.||.
 Worm   440 Q--SHPAAPHLADLANY---------EKRRRSEREERRERERQAHHAMPIARVSASVPAPQQ--- 490

  Fly   518 GQGSQQQAQP-----EAPPRNNRQSSGLSSSGGSASGGGG----SSKPAAALPQQSNNHLGQPVN 573
               |::.::|     ..|...:..:|.||..||..:|...    |..|.|..|::::  :....:
 Worm   491 ---SRKMSEPLLITHVKPEDLDVLASELSKMGGHHNGRSREESMSPPPPAPPPREAS--ISSITD 550

  Fly   574 PLD--PLDSSDSDSEPDEPNDRARN-DGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNR 635
            .:|  .||:. :|:|.|:..|...| :|||..                              ||:
 Worm   551 TIDVGELDNG-ADAEWDDLKDIMMNGEGTLRG------------------------------PNK 584

  Fly   636 PLPPTPDDDDQAGDRTLIMKRKLEQNINRLQKSASTSQANVTPSRRGDESNLLRDWDFDRFFPKN 700
            ||||||.|    |:.||:                               |::.|          |
 Worm   585 PLPPTPTD----GENTLV-------------------------------SDVRR----------N 604

  Fly   701 ANGPRGSGRGSPTTTASLSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKAEPSASQSIAK 765
            .||..|.|                                        .|:..|. |.....|..
 Worm   605 GNGNSGHG----------------------------------------AYKGKKI-PEIRPGIIS 628

  Fly   766 EQGSASGSGSGSGSASGSGSGGSTNSPAHKRQDSDSRLPTNFERGFRRENSDFFPLAKRYSAVFS 830
            .....|.|.:..|           |.|                                  .:|.
 Worm   629 LDDDDSDSDNEEG-----------NEP----------------------------------LMFK 648

  Fly   831 GASASGSTAGSPSAQALQRSSAVYQRNSIYSSSISSKSKENDVPGAPGAAAAGTATASAKPGPAA 895
            ..:||.|
 Worm   649 PINASSS---------------------------------------------------------- 655

  Fly   896 ATTTATKGAAPKTSKSLANFHFLRPRREKTESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQ 960
                  :||.|.          |.|:                        ..|.::|:..|.:|.
 Worm   656 ------RGALPD----------LLPK------------------------SPQLRRQINDQTRQM 680

  Fly   961 NRGGGGGGGGGGGGGGSSGVGADGTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAI 1025
                                                            :..|.|:|:|
 Worm   681 ------------------------------------------------SDDRADESAS------- 690

  Fly  1026 SSSVHSTPSKSFIASSGSGGLGLGGGTVVGGVIISSNHSPQSTISLASSSSNSRQNSPKNSISKT 1090
                                            :..|.:.|           |..|||.
 Worm   691 --------------------------------LFGSFYQP-----------NGFQNSD------- 705

  Fly  1091 RSSSSITNLLHKSASSSSANLHHLTPCSSTSSASISNPLPPHAYALQQKQRSFL-TFGFGAGGSG 1154
             |.|||                                  .|:::.:.:::||: .||.|||..|
 Worm   706 -SRSSI----------------------------------QHSFSNRDREKSFVGYFGGGAGAGG 735

  Fly  1155 -----PSRRE--SHVNVNVTPTSH--EAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLM 1210
                 |.|.:  :.|.|||||.|:  .|.||.||||||||:|:.||||||||||||||||::|||
 Worm   736 GTVNRPGRPQDINQVQVNVTPNSNGTPAENDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLM 800

  Fly  1211 LLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGL--SDQV 1273
            |||||||||||.|||||||.||.||||||||.||||:|.|:||||||||:.|||||:|.  ::..
 Worm   801 LLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTT 865

  Fly  1274 ERRNGWINVGDLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLL 1338
            |:||||:||||||||:|||||:||||||||:.|:.||||||||||||||||:||:||.|.|.||:
 Worm   866 EKRNGWVNVGDLQGAIHFKIVRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLI 930

  Fly  1339 VDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYD 1403
            ||||:||.:||||:|||..||||:|||||.|||||.|..:.....|||||.||||||||||||||
 Worm   931 VDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYD 995

  Fly  1404 NEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRL 1468
            ||||||||.||::||:||||||||:|||||.|||||||||||||||||::|||||||||||||:|
 Worm   996 NEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKL 1060

  Fly  1469 KFLCERNDKVFFSSAKGASSCQIYFMTLNKPGMANW 1504
            |||||||||||||||||..|||||||||||||:.||
 Worm  1061 KFLCERNDKVFFSSAKGGGSCQIYFMTLNKPGLTNW 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	226/273 (83%)
		CNH	1183..1484	CDD:214481	239/302 (79%)
mig-15	NP_001024973.1	STKc_myosinIII_N_like	14..288	CDD:270785	226/273 (83%)
		CNH	773..1076	CDD:214481	239/302 (79%)