DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and tnik

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_031758070.1	Gene:	tnik / 100493253	XenbaseID:	XB-GENE-480067	Length:	1515	Species:	Xenopus tropicalis

Alignment Length:	1649	Identity:	699/1649 - (42%)
Similarity:	922/1649 - (55%)	Gaps:	302/1649 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVL 80
            |||:|||:||:||||||||:|:||||||||||||||.||||||||||||||.|||||||.|||:|
Frog     9 SLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73

  Fly    81 KKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREIL 145
            ||||:||||||||||||||:|||.|||||||||:|||||||||:|:|||.:||||||||||||||
Frog    74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

  Fly   146 RGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACD 210
            ||||:||.:|||||||||||||||:||||||||||||||||||:|||||||||||||||||||||
Frog   139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 203

  Fly   211 ENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDT 275
            ||||||||.:||||||||||:||||..|||||:||||||||||||..||||||||||||..||::
Frog   204 ENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIES 268

  Fly   276 VLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEP 340
            .|||::.|||.||.|:||.||:|||.:|||||||||||||.||::.||:..:|.||||: :::|.
Frog   269 CLVKNHSQRPTTEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSE-EEEED 332

  Fly   341 QLAGEHSSIVQAPGGDTLRRNFQQIQEGRLAAEQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQ 405
            ..:||.|||:..||..||||:|.::|             |..:.:::|.......|.|.:.::.:
Frog   333 NDSGEPSSILNLPGESTLRRDFLRLQ-------------LANKERSEALRRQQLEQQQRENEEHK 384

  Fly   406 QQAAAAAAAAAHAAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHA 470
            :|..|.........::.::..::.|.::.:..:|.:...|::.||  ...|..:|.....:..:.
Frog   385 RQLLAERQKRIEEQKEQRRRLEEQQRREKEMRKQQERDQRRRYEE--QMRREEERRRAEHEKEYI 447

  Fly   471 NRPLPPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPEPQPQ----------TAAGGQGSQQQA 525
            .|.|....:..|...|...|:|.......:..|..:|...:.|          .:...|..|||.
Frog   448 RRQLEEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQAERLQRQLQQERDYLVSLQQQQQQQQR 512

  Fly   526 QPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSSDSDSEPDEP 590
            ..|..|..: ...||:.          :.|||.|...|..:....||.|.....:|..:.:
Frog   513 SSEKKPLYH-YKEGLNP----------AEKPAWAKEVQQRSLSNSPVLPAKQQHTSAIEQQ---- 562

  Fly   591 NDRARNDGTLLASDPPKPLPGLGP-VSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQAGDRTLIM 654
                                  || |::||::...||       |||
Frog   563 ----------------------GPLVTKDASSNWQLS-------NRP------------------ 580

  Fly   655 KRKLEQNINRLQKSASTSQANVTP---------SRRGD-ESNLLRDWDFD-RFF-----PKNANG 703
                  |...||.|......|:.|         ||.|. ..|.::..|.: |:.     .:|..|
Frog   581 ------NSQNLQASGRVKMDNLAPSLILPSIQISRSGPWTQNEVQSLDDEVRYLLQVNSQENEPG 639

  Fly   704 PRG--SGRGSPTTTASLSRSSQLSTLKVDTKLQRAS-------VAEAITRP--VPR-------GY 750
            .:.  |.:||.:...|.:|.|.||.::..::|.|.|       ||..|:.|  .||       |.
Frog   640 RKSVTSLKGSRSQGCSPARDSGLSKVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGV 704

  Fly   751 QPLKAEP-----------------------SASQSIAKEQGSASGSGSGSGSASGSGSGGSTNSP 792
            ||.:..|                       |||||:.::  ||.|       .|....|..::.|
Frog   705 QPARTPPMHRPIDPQQLPLLVSVKTQGSSLSASQSVHEQ--SAKG-------MSAFQEGIISHRP 760

  Fly   793 AHKRQDSDSR-----LPTNFER----GFRRENSD-----------FFPLAKRYSAVFSGASASGS 837
            ...||:||..     ||...|:    .:.|:..|           ..|...|.:...:|.|...|
Frog   761 EMPRQNSDPTSENPPLPPRIEKFDRSSWLRQEEDLPPKVPQRTTSISPALARKNCAGNGNSLGNS 825

  Fly   838 TAGSP---SAQALQRSSAVYQR--NSIYSSSISSKSKENDVPGAPGAAAAGTATASA-------- 889
            .|..|   |...|:|:..|.:.  ..|.|.|.||.|..:..|.:.|.:..|:...|:
Frog   826 LATQPVRASNPDLRRTETVIENPIQRISSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERNRARAG 890

  Fly   890 --KPGPAAATTTATKGAAPKTSKSL-----------------------ANFHFLRPRREKTESVI 929
              ||..:......|..:.|:.::.:                       |:...:.|||.|::...
Frog   891 NNKPEGSPLLPHETSNSKPEENRDVTRPSRPASYKKAIDEAVISQTVPADDGKIMPRRMKSKKTG 955

  Fly   930 VLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSGVGADGTGLGTPGTRT 994
            .:...|: |:.|::|:.::..:.:::.....:          ......|....:|......||..
Frog   956 EMDLTAL-AKELRELRIEETNRPIKKVTDYSS----------SSEESESSEEEEGESEAQDGTVP 1009

  Fly   995 SSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHSTPSKSFIASSGSGGL------------- 1046
            .|.:|.|:....         |.:|.|.|. :..:..:.|::|.:.|..|.|
Frog  1010 VSDIPRLIPTGI---------SGNEPYNAG-TQGMEMSQSETFRSISREGTLMIRETSGDKKRTG 1064

  Fly  1047 -----GLGGGTVVGGVIISSNHSP--QSTISLASSSSNSRQNSPKNSIS-KTRSSSSITNLLHKS 1103
                 |..|...:.. ::..:|||  ..|.:|....:::::....|... ...:.:|.|..:
Frog  1065 HAESNGFAGHINLPD-LVQQSHSPVGTPTEALGRGPTHAQEMDTVNEYGVANNTKASFTPFV--- 1125

  Fly  1104 ASSSSANLHHLTPCSS-------------TSSASISNPLPPHAYALQQKQRSFLTFGFGAGGSGP 1155
                ...::..:|..:             ||:.::..     :..|:|:|...          ..
Frog  1126 ----DPRVYQTSPTDNDDEEDEDDDDDEETSATALFT-----SELLRQEQAKL----------NE 1171

  Fly  1156 SRRESHVNVNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKV 1220
            :|:.|.||||  ||:....:|||||||||||||||||||||||||||:|||||||||||||||||
Frog  1172 ARKISVVNVN--PTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV 1234

  Fly  1221 YQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDL 1285
            |.||:||||||||||||.|:|||||||||::||||||||:::||..|   .:||::.|||.||:|
Frog  1235 YNLINRRRFQQMEVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHND---PEVEKKQGWITVGEL 1296

  Fly  1286 QGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLK 1350
            :|.||:|:||||||||||||||:::|||||||||||||||||:|.:|:|||||.|||:|:..|||
Frog  1297 EGCVHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFTDLQHRPLLCDLTVEEGQRLK 1361

  Fly  1351 VIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRV 1415
            ||:||:.|||.:|:||...||||:|.|.||.|.||.||.||.::||::|:||::|||||||.||:
Frog  1362 VIFGSSTGFHVIDVDSGNTYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRI 1426

  Fly  1416 SKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFF 1480
            :|::||||||||||||||.:.||||||.|||||||||:||||||||||:||||||||||||||||
Frog  1427 TKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFF 1491

  Fly  1481 SSAKGASSCQIYFMTLNKPGMANW 1504
            :|.:...|.|::|||||:..|.||
Frog  1492 ASVRSGGSSQVFFMTLNRNSMMNW 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	230/270 (85%)
		S_TKc	32..296	CDD:214567	224/263 (85%)
		CNH	1183..1484	CDD:214481	226/300 (75%)
tnik	XP_031758070.1	STKc_TNIK	18..313	CDD:270807	250/294 (85%)
tnik	XP_031758070.1	CNH	1197..1495	CDD:214481	226/300 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	480	1.000	Domainoid score	I416
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1126	1.000	Inparanoid score	I227
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	1	1.000	-	-		FOG0001422
OrthoInspector	1	1.000	-	-		otm48244
Panther	1	1.100	-	-	O	PTHR48015
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X885
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160