DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and map4k5

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	NP_001135521.1	Gene:	map4k5 / 100216063	XenbaseID:	XB-GENE-6037447	Length:	861	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	209/676 - (30%)
Similarity:	306/676 - (45%)	Gaps:	165/676 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTE-DEEEEIKLEINVLKKYSNHRNI 89
            |:|...|||::.||:||||.|||.|:.:||:|||:|::.:.: |:...|:.||.::|: ..|.||
Frog    15 KNPQHDFELVQRVGSGTYGDVYKARNLQTGELAAVKIIKLEQGDDFSLIQQEIFMVKE-CKHANI 78

  Fly    90 ATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN 154
            ..|:|:::.:      ::||:.|||||.||:.|:...|  ..|.|..|||:|||.|:||.||||.
Frog    79 VAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLTECQIAYMCRETLQGLGYLHSR 135

  Fly   155 KVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDN 219
            ..:||||||.|:|||||.:|||.||||:|::..||.:|.:||||||||||||.|.::|  ..|:.
Frog   136 GKMHRDIKGANILLTDNGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQ 198

  Fly   220 RSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS--PPRLKSK-KWSKKFHGFIDTVLVKDY 281
            ..|:|::||||:|:||.|||:.||||||||||:.:::  ||:||.| |||:.||.|:...|:|:.
Frog   199 LCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKEKMKWSQSFHNFVKVSLIKNP 263

  Fly   282 HQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDEPQLAGEH 346
            .:||..|.||.|.|:......|.|..:|.|        |.......:.|...|:||.||.....|
Frog   264 KKRPPAERLLTHQFVVQPGLSRIVAQELLD--------KFNNPDSHHHYGEPDDDDPEPLSMVRH 320

  Fly   347 SSIVQAPGGDTLRRNFQQIQEGRLAAEQQQQHHLMAQAQAQAAAAHAAAQAQAQLQQQQQQAAAA 411
                      |:|...:..:..|.|:|..                ....|.:..| :::.:|...
Frog   321 ----------TIRSTSKAARAERTASELN----------------FDKLQFEPPL-RKETEANEG 358

  Fly   412 AAAAAHAAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHANRPLPP 476
            ...:......||..:....|......::..||                             ||||
Frog   359 MGCSRENDFGAQWISFANGANNDSTMKKAVPP-----------------------------PLPP 394

  Fly   477 TP----KCGEPAGQTPQQQQRNS-----QNNFKPSLPPRRPEPQPQTAAGGQGSQQQAQPEAPPR 532
            .|    .|.:   :.....:|:|     |.|..|....|:..|    ..|.||:..
Frog   395 KPVRMNSCPD---ENMDDSERSSTIKHQQENRAPQFHRRQSSP----GCGHQGALS--------- 443

  Fly   533 NNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPL-DPLDSSDSDSEPDEPNDRARN 596
            :|..:|.:||.|               |....|..:|...:|: .|:...   .:|..|..:.:.
Frog   444 HNVLTSSISSPG---------------LYSSRNCDMGNGDSPVRSPIGEG---GKPQLPQKKEKK 490

  Fly   597 D--GTLLASDPPKPLPGLG----------PVSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQ--- 646
            |  .:::...||.|...:|          |:.  .|..|...|             ||..||
Frog   491 DIPKSVINGLPPTPKVLMGACFSKVFDGCPLK--INCATSWIH-------------PDTKDQYII 540

  Fly   647 ----AGDRTLIMKRKLEQNINRLQKS 668
                .|..||        |:|.|.::
Frog   541 FGSEDGIYTL--------NLNELHEA 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	136/273 (50%)
		S_TKc	32..296	CDD:214567	134/267 (50%)
		CNH	1183..1484	CDD:214481
map4k5	NP_001135521.1	STKc_MAP4K5	11..278	CDD:270813	136/273 (50%)
		S_TKc	21..278	CDD:214567	134/267 (50%)
		CNH	525..841	CDD:214481	12/55 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910