DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msn and map4k3

DIOPT Version :9

Sequence 1:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster
Sequence 2:	XP_012818238.1	Gene:	map4k3 / 100170570	XenbaseID:	XB-GENE-951441	Length:	924	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	212/688 - (30%)
Similarity:	305/688 - (44%)	Gaps:	177/688 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLE 76
            |..|.|      :.::|...||||:.:|:||||.|||.|:..||:||||||:.:...|:..:..:
Frog     2 STGCDL------SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60

  Fly    77 INVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYIC 141
            ..::.|...|.||..|:|:::::      |:||:.||:||.||:.|:...|  ..|.|:.|||:.
Frog    61 EIIMMKDCKHTNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSEQQIAYVS 117

  Fly   142 REILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEV 206
            ||.|:||.||||...:||||||.|:|||||..|||.|||||||:..||.:|.:||||||||||||
Frog   118 RETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEV 182

  Fly   207 IACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS--PPRLKSK-KWSKK 268
            .|.:..  ..|:...|:|::|||::|:||.|||:.||||||||||:.:::  ||:||.| |||..
Frog   183 AAVERK--GGYNQLCDIWAVGITSIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245

  Fly   269 FHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGS 333
            ||.||...|.|:..:||..|.||:|.|: .||.:|.:.|:|.|.::          ..|:. |..
Frog   246 FHHFIKMALTKNPKKRPTAEKLLQHPFL-TQPLNRTLAIELLDKVN----------NPDHS-SFH 298

  Fly   334 DNDDDEPQLA--GEHSSIVQAPGGDTLRR----------------------------------NF 362
            |.|||:|:..  |     :.:|....:||                                  ||
Frog   299 DFDDDDPEFKFWG-----IFSPASPPVRRAPRFAARPKPMVVVPHRIHSTSRSVREEKTRSEINF 358

  Fly   363 QQIQ-EGRLAAEQQQQHHLMAQAQA--QAAAAHAAAQAQAQLQQQQQQA-------AAAAAAAAH 417
            .||: :..|..|.:..|.|:.:...  .|...:..|::...||.:..|.       .|..:....
Frog   359 GQIKFDPPLRKETEPHHDLLDRDDLLDSAEDIYYTARSNLDLQLEYGQGPQSNYFLGANKSLLKS 423

  Fly   418 AAQQAQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHAN--------RPL 474
            ..::..|....|..:....:......|..:.:.| ||..|..:.|.:|...:|:        :..
Frog   424 VEEELHQRGHVAHLEDDDGDDDESKHSTIKPKVP-PPLPPKPKSIYIPQESNASEDDNQGTIKRC 487

  Fly   475 PPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPEPQPQTAAGGQGSQQQAQPEAPPRNNRQSSG 539
            |.:.....||...|.:..           |||.|..:|.....|.||...
Frog   488 PVSESLARPASYVPPRPP-----------PPRLPPHKPNALGNGVGSFHL--------------- 526

  Fly   540 LSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVN-PLDPLDSSDSDSEPDEPNDRARNDGTLLAS 603
                        ...|..::|.|||.|...:.:| |                   .|.|    ..
Frog   527 ------------NGDKEMSSLSQQSENQNSKSLNLP-------------------TRKD----KK 556

  Fly   604 DPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTP 641
            |.||                |:|:|        |||||
Frog   557 DVPK----------------PISNG--------LPPTP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	134/273 (49%)
		S_TKc	32..296	CDD:214567	133/266 (50%)
		CNH	1183..1484	CDD:214481
map4k3	XP_012818238.1	STKc_MAP4K3_like	15..272	CDD:270788	133/266 (50%)
		S_TKc	16..273	CDD:214567	133/266 (50%)
		CNH	591..904	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910