Protein Alignment Ref1 and Alyref2

DIOPT Version :10

• Sequence 1: NP_651968.1
• Gene: Ref1 / 44029
• FlyBaseID: FBgn0010774
• Length: 266
• Species: Drosophila melanogaster
• Sequence 2: NP_062357.3
• Gene: Alyref2 / 56009
• MGIID: 1913144
• Length: 218
• Species: Mus musculus
• Alignment Length: 263
• Identity: 112/263 - (42%)
• Similarity: 139/263 - (52%)
• Gaps: 55/263 - (20%)

  Fly     1 MVDKIEMSLDDIIKSTRSQKKPQAARGGPGGARKTGGQQRFAGGARRGGANAGGSPRKPGSVLKG 65
            |.||::||||||||..|:|::                            .|.||.||:....:
Mouse     1 MADKMDMSLDDIIKLNRNQRR----------------------------VNRGGGPRRNRPAI-- 35

  Fly    66 PRGGVAAGAVQKAKFPRGDVNSAWKHDMYDGPKRGAVGGGSG---PTRLIVGNLDYGVSNTDIKE 127
            .|||....|......|..|   .|:||::|    ...|||.|   ..:|:|.|||:|||:.||:|
Mouse    36 ARGGRNRPAPYSRPKPLPD---KWQHDLFD----SGCGGGEGVETGAKLLVSNLDFGVSDADIQE 93

  Fly   128 LFNDFGPIKKAAVHYDRSGRSLGTADVIFERRADALKAIKQYHGVPLDGRPMTIQLAVSDVAVLT 192
            ||.:||.:|||||.|||||||||||||.||||||||||:|||.|||||||||.|||..|.:....
Mouse    94 LFAEFGTLKKAAVDYDRSGRSLGTADVHFERRADALKAMKQYKGVPLDGRPMDIQLVTSQIDPQR 158

  Fly   193 RPVAATDVKRRVGGTAPTSFKRGGGQAGGTARRGFKRPVGGKPAAGGQRRERKAPPTAEELDAEL 257
            ||..:       |.....:..||.|..||...:|..|..|        |..::...:||||||:|
Mouse   159 RPAQS-------GNRGGMTRSRGSGGFGGRGSQGRGRGTG--------RNSKQQQLSAEELDAQL 208

  Fly   258 DSY 260
            |:|
Mouse   209 DAY 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ref1	NP_651968.1	sex-lethal	31..>184	CDD:273740	76/155 (49%)
		RRM_THOC4	109..183	CDD:410081	56/73 (77%)
		FoP_duplication	202..>260	CDD:464005	18/57 (32%)
Alyref2	NP_062357.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		24/86 (28%)
		FYTT	3..>32	CDD:462082	17/56 (30%)
		Sufficient for RNA-binding, interaction with NXF1-NXT1	16..37		7/50 (14%)
		Interaction with HHV-8 ORF57 protein and with ICP27 from HHV-1	54..155		68/107 (64%)
		RRM_THOC4	75..149	CDD:410081	56/73 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..218		22/76 (29%)