DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ref1 and HNRNPA1

DIOPT Version :10

Sequence 1:NP_651968.1 Gene:Ref1 / 44029 FlyBaseID:FBgn0010774 Length:266 Species:Drosophila melanogaster
Sequence 2:NP_112420.1 Gene:HNRNPA1 / 3178 HGNCID:5031 Length:372 Species:Homo sapiens


Alignment Length:141 Identity:43/141 - (30%)
Similarity:54/141 - (38%) Gaps:38/141 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 AARGGPGGARKTGGQQRFAGGARRG-------GANAGGSPRKPGSVLKGPRGGVAAGAVQKAKFP 81
            :.|||.||:|..||.    ||:..|       |...||.|...|    |.||..:.|.      .
Human   223 SGRGGFGGSRGGGGY----GGSGDGYNGFGNDGGYGGGGPGYSG----GSRGYGSGGQ------G 273

  Fly    82 RGDVNSAW----KHDMYDGPKRGAVGGGSGPTRLIVGNLDYGVSNTDIKELFN---DFGPIKKAA 139
            .|:..|.:    .:|.|:....|..|||||      .|...|.|..|.....|   :|||:|.. 
Human   274 YGNQGSGYGGSGSYDSYNNGGGGGFGGGSG------SNFGGGGSYNDFGNYNNQSSNFGPMKGG- 331

  Fly   140 VHYDRSGRSLG 150
               :..|||.|
Human   332 ---NFGGRSSG 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ref1NP_651968.1 sex-lethal 31..>184 CDD:273740 39/134 (29%)
RRM_THOC4 109..183 CDD:410081 13/45 (29%)
FoP_duplication 202..>260 CDD:464005
HNRNPA1NP_112420.1 Globular A domain 4..94
RRM1_hnRNPA1 12..92 CDD:410154
Globular B domain 95..185
RRM2_hnRNPA3 105..184 CDD:409996
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..216
RNA-binding RGG-box 218..240 9/20 (45%)
HnRNPA1 312..344 CDD:463312 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..372 9/27 (33%)
Nuclear targeting sequence (M9) 320..357 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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