Protein Alignment Ref1 and RBMX

DIOPT Version :10

• Sequence 1: NP_651968.1
• Gene: Ref1 / 44029
• FlyBaseID: FBgn0010774
• Length: 266
• Species: Drosophila melanogaster
• Sequence 2: NP_002130.2
• Gene: RBMX / 27316
• HGNCID: 9910
• Length: 391
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 51/215 - (23%)
• Similarity: 78/215 - (36%)
• Gaps: 73/215 - (33%)

  Fly   108 PTRLIVGNLDYGVSNTDIKELFNDFGPIKKAAVHYDR-SGRSLGTADVIFERRADALKAIKQYHG 171
            |.:|.:|.|:...:...::.:|..:|.|.:..:..|| :.:|.|.|.|.||..|||..|.:..:|
Human     7 PGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNG 71

  Fly   172 VPLDGRPMTIQLAVSDVAVLTRPVAATDVKRRVGGTAPTSFKRG------GGQAGGTARRG---- 226
            ..|||:.:.::.|       |:|  :.:..||  |..|....||      ||:.|....||
Human    72 KSLDGKAIKVEQA-------TKP--SFESGRR--GPPPPPRSRGPPRGLRGGRGGSGGTRGPPSR 125

  Fly   227 -----------------------FKRPVGGKPAAGGQRRERKA---------------------- 246
                                   .||  |..|.:||...:|.|
Human   126 GGHMDDGGYSMNFNMSSSRGPLPVKR--GPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRD 188

  Fly   247 ----PPTAEELDAELDSYIN 262
                ||..|.|.:..|.|::
Human   189 SYGGPPRREPLPSRRDVYLS 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ref1	NP_651968.1	sex-lethal	31..>184	CDD:273740	23/76 (30%)
		RRM_THOC4	109..183	CDD:410081	22/74 (30%)
		FoP_duplication	202..>260	CDD:464005	24/116 (21%)
RBMX	NP_002130.2	RRM_RBMX_like	7..86	CDD:409816	24/85 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..391		35/161 (22%)
		dnaA	165..>306	CDD:455861	7/44 (16%)
		RBM1CTR	173..217	CDD:400429	6/36 (17%)
		Necessary for the association to nascent RNAPII transcripts and nuclear localization	186..236		6/23 (26%)
		Necessary for RNA-binding	333..391