Protein Alignment Ref1 and Ncl

DIOPT Version :10

• Sequence 1: NP_651968.1
• Gene: Ref1 / 44029
• FlyBaseID: FBgn0010774
• Length: 266
• Species: Drosophila melanogaster
• Sequence 2: NP_035010.3
• Gene: Ncl / 17975
• MGIID: 97286
• Length: 707
• Species: Mus musculus
• Alignment Length: 221
• Identity: 48/221 - (21%)
• Similarity: 86/221 - (38%)
• Gaps: 56/221 - (25%)

  Fly     3 DKIEMSLDDIIKSTRSQKKPQAARGGPGGARKTGGQQRFAGGARRGGANAGGSPRKPGSVLKG-- 65
            |:.|...||    ...:::.:..:..||..:|...:|:.|..|::.... |..|..|.::..|
Mouse   257 DEEEDDEDD----DEEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKVE-GSEPTTPFNLFIGNL 316

  Fly    66 -PRGGVAAGAVQKAKFPRGDV---NSAWKHDMYDGPKR--GAV---------------------- 102
             |.     .:|.:.||...::   |.....|:..|..|  |.|
Mouse   317 NPN-----KSVNELKFAISELFAKNDLAVVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGN 376

  Fly   103 --------GGGSGPTR----LIVGNLDYGVSNTDIKELFNDFGPIKKAAVHYDRSGRSLGTADVI 155
                    |..|...|    |:..||.:.::..::||:|.|...|:..:    :.|:|.|.|.:.
Mouse   377 EIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAMEIRLVS----QDGKSKGIAYIE 437

  Fly   156 FERRADALKAIKQYHGVPLDGRPMTI 181
            |:..|||.|.:::..|..:|||.:::
Mouse   438 FKSEADAEKNLEEKQGAEIDGRSVSL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ref1	NP_651968.1	sex-lethal	31..>184	CDD:273740	42/193 (22%)
		RRM_THOC4	109..183	CDD:410081	22/77 (29%)
		FoP_duplication	202..>260	CDD:464005
Ncl	NP_035010.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..308		12/55 (22%)
		PRK13808	<12..142	CDD:172341
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	309..383	CDD:409837	11/78 (14%)
		RRM2_NCL	392..467	CDD:409838	22/76 (29%)
		RRM3_NCL	486..558	CDD:409839
		RRM4_NCL	569..646	CDD:409840
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..707