Protein Alignment UNC13C and git1

DIOPT Version :10

• Sequence 1: NP_001074003.1
• Gene: UNC13C / 440279
• HGNCID: 23149
• Length: 2214
• Species: Homo sapiens
• Sequence 2: NP_596600.1
• Gene: git1 / 2540617
• PomBaseID: SPBC21C3.20C
• Length: 1098
• Species: Schizosaccharomyces pombe
• Alignment Length: 1264
• Identity: 213/1264 - (16%)
• Similarity: 388/1264 - (30%)
• Gaps: 476/1264 - (37%)

Human  1156 SKHGAE--DKTQTIITAMKERMKI-----REKNRPEV------FEVIQEMFQISKEDFVQFTKAA 1207
            |:..|:  ::...::..:||.:.|     .|:|.|.:      |..:.|  |:.:..|
pombe    27 SRRNAKQIERENALLDQIKELLSIAIIQCHERNIPSIDLPPSFFNYVCE--QLPRHPF------- 82

Human  1208 KQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFY 1272
                        |||..:.:....|           :..:.:.....|    |.|.:.  ||...
pombe    83 ------------AKIASSYIDTHTL-----------FFQISISSFLCR----FSNCSE--DEIRL 118

Human  1273 FECHNSTDRIKVRVWDEDDDIKSRVKQHFKKE---------SDDFLGQTI--------------V 1314
            |:.|.|.|...:.::|      .....||..|         |..:|..|:              :
pombe   119 FKQHQSLDSFLLSLFD------LLCSHHFSVEFTSISLIIKSSQWLFYTLSDYAHESLTGVEADI 177

Human  1315 EVRTLSGEMDVWYNLEKRT----------DKSAVS------GAIRL-KINVEIKGEEKVAPYHIQ 1362
            ..:.||...|.|...|::.          |.|.:|      |...: ..|..|...|.:.|.:|.
pombe   178 TTKFLSTLADTWPEFEEQCTLSKHLFLLGDFSLISYVKVLCGVFNIPNYNAFILSVEDLLPENIS 242

Human  1363 YTCLHENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMR------YGIESIYQA 1421
            :..:.:........:..|.     .::.|       |.:|:.:.|::..|      ..|..|:|.
pombe   243 FAAVADFQLSKYRAINDNS-----VLRSD-------DFSSKAVFDKYVERECYYSENAISKIFQN 295

Human  1422 MTHFSCLSSKYM-CPGVPAVMSTLLANINAF--------------------YAHT---TVSTNIQ 1462
            ....:.|..:.. ..|...::|.:| |.|.:                    |.::   .:.||:.
pombe   296 YPDLAVLFEELQYAEGNNDLLSAIL-NTNKYTLRPDDCAPYFYRLMDLCLRYCYSQSNEIGTNVL 359

Human  1463 VSASDRFAATNFGR-------------------EKFIKLLD--------------------QLHN 1488
            .|.:..|  .|..|                   :|.:|..|                    .:|
pombe   360 WSMTTSF--INIWRIHPGTCCCVVLSIYWPYLEDKLLKFSDLGDIFEYFFSLIHDCDYAIWSVH- 421

Human  1489 SLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDST 1553
                |..::.|.....:...|.||                |.||.|.|::|    |..||.||..
pombe   422 ----DEHQFSELLAFYHRRALNDL----------------VEELGSCPRSS----DSCRAILDIL 462

Human  1554 YKYIFDNC-------HELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDED----- 1606
            ..||| :|       .||..|.||..||.   :|..|      :|:..|:...:|...|.
pombe   463 NNYIF-SCPLFLVTPEELEEQYTDFFKKL---KEKYG------EFFQNLLKKELTGKPESDLEGL 517

Human  1607 -------KTAYTPVLNQFP----QELNMGKISAEIMWTLF----------------------ALD 1638
                   :..|..:.:.|.    .:|::....||....||                      .|:
pombe   518 RLVGVQLQATYENLKSNFSARIFNQLSVHSFFAEATCHLFLEKLPTITKTYVYSNCKEIPDHILE 582

Human  1639 MKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDV 1703
            |..||.: :.:.|...|.|::         ::|.:...||...          ||.:.|....|.
pombe   583 MINALYQ-QTRALVACTGYLS---------SDYPKIYEAFSGT----------FVYRNLSLIIDK 627

Human  1704 SMEFLHGALGRD----KKDGFQQTSEHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRR 1764
            .:..:...:.|:    |:..|        :|.|...:.|.|...::.::|::.|:.:..:.....
pombe   628 GLANVLQTVLRESFIPKRSRF--------YSDSTKMILAPLQDCYDFLQKIDWPSSKDANRFYLH 684

Human  1765 FAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILK 1829
            ..|.....:..|   |.|.::......::|           ::.|.:...:..|:|..:||...:
pombe   685 LGKLSENYIHYY---VDSMYALFIYSTDIP-----------LKAEPLVPDLPVKQLKEKASHFKR 735

Human  1830 ELQVKLSGVLDELSVTYGESFQVIIEECIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMD 1894
            .     ||..:.|.: |.|||.:|  ..:..:|..|..:...           :|.:|:...:|.
pombe   736 H-----SGDPNFLKL-YRESFTLI--NTVSLVSGWLKMLHQR-----------IDYKILTEKVMH 781

Human  1895 FLD-----KTLSLSAKICEKTVLKR------VL-----------------------KELWKLVLN 1925
            |.|     .|:.:|.|:....|..:      ||                       ||.:::.:.
pombe   782 FKDMEVPSATVIISIKMAHLLVTPKAPYSFSVLLQDPESEFCVHTRDVYDELVPNWKETYQMEIT 846

Human  1926 KIEK-QIVLPPLTDQTGPQMIFIAA--------------KDL-------GQ-LSKLKEHMIRE-- 1965
            .::: ::::......||.:.::..|              ||:       || |..|:..:.||
pombe   847 NVKRFKLIIYQRNIHTGLETVYGHATLEVDPDKLKQGHGKDVWLDITNKGQILIGLRVLLKRETP 911

Human  1966 ------DARGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDAL 2024
                  ....||..:..::.|::.::.::.        :|.|..|..:..:||.........:|.
pombe   912 NYYCFAQMEYLTVTEVKMLNVLMISLSKFI--------RNSLRNSGLMDFVRYLDGDENDNAEAE 968

Human  2025 IKKFIDTQTSQSRSSKDA-------------------------------VGQISVHVDITATPGT 2058
            .|:.:|  ..|:|..|:.                               .|.:....||...|.|
pombe   969 TKEKMD--ELQARCEKEQQSLLAELDDFFYWIYVNLLPKPLFYLLSRLWFGLLETFRDILVPPVT 1031

Human  2059 GDHKVTVKVIAIND------LNWQTT--AMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYN 2115
            ..   |::.|.:|.      .:|...  ..||.|.::.
pombe  1032 DS---TLRRIPLNKRELKMVYSWLQLFYDFFRNFQDIA--------------------------- 1066

Human  2116 ETFQFILGKENRPGAYELHLSVKDYCFAR 2144
             .|.|:...|     |:..:::|||.|.:
pombe  1067 -PFDFLNTDE-----YKSVMAIKDYYFVK 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13C	NP_001074003.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..458
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..518
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..629
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..739
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	761..780
		C1_Munc13-2-like	1079..1160	CDD:410409	1/3 (33%)
		C2B_Munc13	1220..1346	CDD:175993	29/165 (18%)
		MUN	1540..2028	CDD:461870	106/601 (18%)
		C2C_Munc13	2062..2181	CDD:176041	15/91 (16%)
git1	NP_596600.1	C2	806..900	CDD:472691	11/93 (12%)