Protein Alignment UNC13C and unc13c

DIOPT Version :10

• Sequence 1: NP_001074003.1
• Gene: UNC13C / 440279
• HGNCID: 23149
• Length: 2214
• Species: Homo sapiens
• Sequence 2: XP_073786252.1
• Gene: unc13c / 100034491
• ZFINID: ZDB-GENE-060503-478
• Length: 2346
• Species: Danio rerio
• Alignment Length: 2387
• Identity: 1562/2387 - (65%)
• Similarity: 1815/2387 - (76%)
• Gaps: 218/2387 - (9%)

Human     1 MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAG-QTKSPKFSYTFKSTVK 64
            ||:..||.| ..||.|:|||||||||..|.|.||..:.||:....:.. ..::|.||.|.|||||
Zfish     1 MVSAHFKKL-SSYIVKICKGMFTKKLATTTKKKESSENKKEPKSTSPELHARNPTFSTTLKSTVK 64

Human    65 KIAKCSSTHNLSTEEDEASKE-FSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQELSSIESSYS 128
            ||:|||||.|:|.|||:...: .||||||||||||||||.|||...|::    ..|:.||:|.||
Zfish    65 KISKCSSTRNISLEEDDGKTDCSSLSPTFSYRVAIANGLPKNALFLNNE----FHEVLSIDSDYS 125

Human   129 ESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGER----TLHGLKLGALRKLRKWKK 189
            :||||.:.......|..:||||||||||..|||||:|||:|||    :||.|:||||:|||||||
Zfish   126 DSLNEAKLVHRFDEQKAYTMPVRRNRKSLISLAPSDGSSEGERGERSSLHTLRLGALKKLRKWKK 190

Human   190 SQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTHDVMEMIFKELQGIS 254
            ||||||||||.|..:|:.|||||||||..|:.||..||||.||:||||||.||||||||||||||
Zfish   191 SQECVSSDSEASNWRKTLGIRSKSLDRAGRHQKTTTLEPGSSSTGCISQTQDVMEMIFKELQGIS 255

Human   255 QIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRRETRDIHDYIKHLGHMGSKA 319
            |||:|||||||||||||.||||||||||||||||||||:||||||||||||||||:.:....:||
Zfish   256 QIESELSELRGHVNALKSSIDEISSSVEVVQSEIEQLRSGFVQSRRETRDIHDYIRQISQQSNKA 320

Human   320 SLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETP 384
            :||||||.||::|..|.::||||.:||||.||..|.|||.|.|:|.||:|.|||||||:|.|.:|
Zfish   321 TLRFLNVPEEKYEKTEELIYQILKEKMGFIDARKAFKIELAHRLGQQRECYNAKPRPIIVIFASP 385

Human   385 QQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKGIPSSQTYESMAIKLSTPEPKIKKNNWQSP 449
            |.||.||||.||||||||.||||.|.||.:|::||.|.||||||||.||:|..: |.:.::|.|.
Zfish   386 QDRDLVLKKCYKLKGTGISISTDSLAHDSKEKREKPIASSQTYESMDIKVSAKD-KAESDDWDSM 449

Human   450 DDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDYDKISSQL 514
             :||::|: :||:|.||::||         ..|.|||    .|.|:.:..|:.:.|.|....:..
Zfish   450 -ESDKELD-ELNKNKYAIVSK---------PLPKSKS----DKKKSHDHRRMGDDSPYSVHYADN 499

Human   515 PESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLL 579
            ...|..:||:.::|:|.||.|.||||:.|.||||||||.|||||||||||||:|:|||.||.|||
Zfish   500 TAYDDPDKQSKSYYSDITPGWLSQSDYSTPKLSRSESDCSKLCQSYSEDFSESQYFTRVNGCSLL 564

Human   580 SSSDRELWQRKQEGTA-TLYDSPKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHY 643
            ||||:||||||||..| :.|.||..|.|:.....:: ..|.|.|||:|||:|||:||.|||||||
Zfish   565 SSSDQELWQRKQEDMASSWYASPPSQTLSQDRPYVE-HNEVETTETIDSGVSNGLVCISGDRSHY 628

Human   644 SDSQLSLHEDLSPWKEWN---QGADLGLDSSTQEGFDYETNSLFD------------QQLDVYNK 693
            |.|||||..||||||:|:   ||||.|||:||::....|.:|.||            :.|:|
Zfish   629 SGSQLSLQGDLSPWKDWHHLEQGADSGLDASTEQNIISEISSPFDPAANPGFPEKIIKCLEV--- 690

Human   694 DLEYLGKCHSDLQDDSESYD-------------------------------------------LT 715
            ||::.|:....|....|:.|                                           |.
Zfish   691 DLQFEGETFLTLDSTPETGDQDIDMEPEFLEPELEPEVEAVIEPMIKQEREPMPQPEPELEPELE 755

Human   716 QDDNSSPCPGLDNEPQGQWV-------------------------------------GQYDSYQG 743
            .:....|.|..:.||:.:.|                                     .|....|.
Zfish   756 PEPEPEPEPEQEPEPEPEPVIEPIPKPVPVSVSKPVVEQQTEKKPKTKKIQAKPESAPQTLQRQD 820

Human   744 ANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKSAL 808
            .| :.|.|||.. |.|||||||::::..||. ||||.||||||||:|||.|..||||||||||||
Zfish   821 VN-HHLQQNQKS-SAMYRSQSEIRNEKVEDV-PKSWSSRLSIDLSEKTFGFGGFGSTLQRAKSAL 882

Human   809 EVVWNKSTQSLSG--YEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDY---- 867
            :.||||.:||.|.  .|.|.:|.||||||  .||||.||||:||||||||:|||||:||..
Zfish   883 DFVWNKGSQSTSAPVEETSNTSFMGRFRT--TSTANSSSTTIDSDVYTEPFYYKAEEEEQQQQQP 945

Human   868 TEPVADNETDYVEVMEQVLAKLENRTSITETDEQMQAYDH-LSYETPYETPQDEG----YDGPAD 927
            .|...||||.||||||||||.|||||:..|.:||.|..:: :|.|  |:..||..    ||...|
Zfish   946 AEQPVDNETHYVEVMEQVLANLENRTNANEPEEQYQEEEYNVSQE--YDLSQDANLVLEYDCSLD 1008

Human   928 DMVSEEGLE-----PLNETSAEMEI---------------------------------------- 947
            :...||..|     |:.|.:||.|:
Zfish  1009 EQYDEEYSEDYDDNPMTEDTAEYEVSLVDYVEETEEPEAETEEQEEVKEEVREVQETSEIKGEDV 1073

Human   948 ------REDENQNIPEQPVEITKP-KRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARI 1005
                  :||||:|:.|.||:...| |||||:|||||||||:|||||||::||||||:::|.:.|
Zfish  1074 VKETVEQEDENKNVTEVPVQEAPPKKRIRPTFKEAALRAYRKQMAELEQQILAGDSTALDTEGR- 1137

Human  1006 VSGNDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTS 1070
              .|.||.:|...  ..||.|..|||||||||||||:|:|||||  :||||||:|::..:|.|::
Zfish  1138 --ANILDPAKLGL--TGGGVGSILYGIDSMPDLRRKRTMPIVRD--LTLAARKAGIAFGLVNRST 1196

Human  1071 LNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKC 1135
            |||||||:||.:|||||||||:|||.||||||||||.||||:||||||||||||||:|.||||||
Zfish  1197 LNNEELKLHVLRKTLQALIYPISSTTPHNFEVWTATAPTYCHECEGLLWGIARQGMRCSECGVKC 1261

Human  1136 HEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF 1200
            ||||||||||||||||.|||||||||||||.||.|||||||||||||||||||||||||:|||||
Zfish  1262 HEKCQDLLNADCLQRAVEKSSKHGAEDKTQNIIMAMKERMKIREKNRPEVFEVIQEMFQLSKEDF 1326

Human  1201 VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNP 1265
            :...|.|||:||:|||||||||||||:.|||||||||||||||||||||||.||||||:||||||
Zfish  1327 ITHLKTAKQAVLEGTSKWSAKITITVLCAQGLQAKDKTGSSDPYVTVQVGKTKRRTKTVFGNLNP 1391

Human  1266 VWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLE 1330
            ||||||:|||||:|||||||||||||||||||||||||||||||||||:|||.||||||||||||
Zfish  1392 VWDEKFFFECHNATDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIIEVRMLSGEMDVWYNLE 1456

Human  1331 KRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGGVKIPEVKGDEAWK 1395
            ||||||.|||||||||:||:||||||||.|.|||||||||||||||||:||.||||:||||:|||
Zfish  1457 KRTDKSMVSGAIRLKISVEMKGEEKVAPPHGQYTCLHENLFHYLTEVKNNGVVKIPQVKGDDAWK 1521

Human  1396 VFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTVSTN 1460
            |:|||.|||||||||||:|:|||||||||||||||||||||||||||.|||||||::||||.:|.
Zfish  1522 VYFDDVSQEIVDEFAMRFGVESIYQAMTHFSCLSSKYMCPGVPAVMSNLLANINAYFAHTTTATT 1586

Human  1461 IQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFF 1525
             .:||||||||:|||||||:||||||||||||||||||:||||.|.|||.|||||||||||||||
Zfish  1587 -NISASDRFAASNFGREKFVKLLDQLHNSLRIDLSKYRDNFPAGNPERLHDLKSTVDLLTSITFF 1650

Human  1526 RMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLTDPSKKQDIPREDQGPTTKNLD 1590
            ||||.||||||:|||||||||:||||||||||||||||||:||.|.:|||::|||:|||:.||||
Zfish  1651 RMKVQELQSPPRASMVVKDCVKACLDSTYKYIFDNCHELYNQLLDQAKKQELPREEQGPSIKNLD 1715

Human  1591 FWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFALDMKYALEEHENQRLCKST 1655
            |||:||||||::||||:|||||::||||||||||||||||||:|||||||||:|||:..||||||
Zfish  1716 FWPKLITLMVSVIDEDRTAYTPIINQFPQELNMGKISAEIMWSLFALDMKYAMEEHDKHRLCKST 1780

Human  1656 DYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGF 1720
            :|||||||||||||||||:|||||...|||||||||||:|||||||||:|:||:|||.|||||||
Zfish  1781 EYMNLHFKVKWFYNEYVRDLPAFKGVPPEYSLWFEPFVIQWLDENEDVAMDFLNGALERDKKDGF 1845

Human  1721 QQTSEHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFS 1785
            |||||||||||||||||.|||||||||||||||||.||:|.||||||||||||:|||||:|.|||
Zfish  1846 QQTSEHALFSCSVVDVFTQLNQSFEIIKKLECPNPHALAHFMRRFAKTINKVLIQYAAIISKDFS 1910

Human  1786 SHCDKENVPCILMNNIQQLRVQLEKMFESMGGKE---------LDSEASTILKELQVKLSGVLDE 1841
            :|..||.|||||:||||||||||||||||||||:         ||:|||.:|||||.||:.||||
Zfish  1911 NHLSKEKVPCILLNNIQQLRVQLEKMFESMGGKQEEGTVVFCKLDAEASELLKELQNKLNTVLDE 1975

Human  1842 LSVTYGESFQVIIEECIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKI 1906
            ||..:|.||:.:||:|:|||:.||.||:.|   ..||::||||||.|||.|||.|||.|.|.|||
Zfish  1976 LSAVFGSSFKPVIEDCVKQMNQELVQMKGN---AGNKSNAAMDAETVLRPLMDLLDKNLMLFAKI 2037

Human  1907 CEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQT-GPQMIFIAAKDLGQLSKLKEHMIREDARGL 1970
            |||||||||||||||:|||.||:|||||||:||| |.||||.||||||||||||||:|||:||.|
Zfish  2038 CEKTVLKRVLKELWKIVLNTIERQIVLPPLSDQTQGAQMIFSAAKDLGQLSKLKEHVIREEARSL 2102

Human  1971 TPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQ 2035
            :|||||.|::||.|||||||||||||||.||||||||:||:||||||||.|||||||:|.|||||
Zfish  2103 SPRQCAAMDLVLPTIKQYFHAGGNGLKKTFLEKSPDLKSLKYALSLYTQPTDALIKKYICTQTSQ 2167

Human  2036 SRSSKDAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK 2100
            .:|:..:.|:::|.||:.:.||||:|||:|||:.:|::||||.||||||||:..:||:|.|||||
Zfish  2168 GQSTTGSFGEVAVQVDLISHPGTGEHKVSVKVVGVNNINWQTNAMFRPFVEINAIGPHLADKKRK 2232

Human  2101 QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSY 2165
            ..||||:|.||||||||||::|..|:.|.|||||:||||||||||||||||||:||:.:|||||.
Zfish  2233 FSTKTKNNNWSPKYNETFQYVLSNEHGPEAYELHISVKDYCFAREDRIIGMTVLQLRELAEKGSL 2297

Human  2166 GAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEE 2212
            ||.|||:::||||||||||:|||||||:|:|||||||||::|||.||
Zfish  2298 GACYPLIRSISMDETGLTIMRILSQRTNDEVAKEFVRLKTDTRSAEE 2344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13C	NP_001074003.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..50		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..174		27/49 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..458		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..518		9/46 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..629		12/30 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..739		9/112 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	761..780		10/18 (56%)
		C1_Munc13-2-like	1079..1160	CDD:410409	71/80 (89%)
		C2B_Munc13	1220..1346	CDD:175993	116/125 (93%)
		MUN	1540..2028	CDD:461870	392/497 (79%)
		C2C_Munc13	2062..2181	CDD:176041	84/118 (71%)
unc13c	XP_073786252.1	None