|
Fly 118 SSSLSSSSSSNSSESKDTNFEYEDEWNIGGIPELLDDLDADIEKSAHSSGGGNQATALNAKQANS 182
|.::|::.......:.|| ::..|:|.| |:..|:.|||||:||. .|...:| ||
Human 2 SVNISTAGKGVDPNTVDT-YDSGDDWEI-GVGNLIIDLDADLEKD-------RQKFEMN----NS 53
Fly 183 SSTSSSSSSKGGASSSSSSAAATGSSSSHKSHKTTLHSNLSATSPTTIKFTRQPVAIGGANSSSS 247
::|:|||:||.....:||.|.|| |.....:|| :
Human 54 TTTTSSSNSKDCGGPASSGAGAT------------------AALADGLKF--------------A 86
Fly 248 SSAAAAPSGGSANVVAKGSSSSSSSTSSSSSGKHHHHHHHHSNSSSSGSSSKGYKSALVAQLNSP 312
|..|:||.|.| |...|.|....||..|.
Human 87 SVQASAPQGNS----------------------------HKETSKSKVKRSKTSKD--------- 114
Fly 313 SPLNSNSKSLSGSGSGSGNTNGAAGAGAGSTLSSSTFAGFSKGGSLVSSSAGAAAALAAGSGQ-- 375
|..:|.|:...|..: :||: |..|
Human 115 ---------------------------ANKSLPSAALYGIPE----ISST---------GKRQEV 139
Fly 376 QGSKFSAGGMSSQTG----SGSGGNNTSNSNNSSSGSGGSGSGSSTGNTASGSGNNNSTSAGGPP 436
||....|.||:|..| ||..||..|||.::|:.:..:|:||
Human 140 QGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGS--------------------- 183
Fly 437 SSQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQ 501
.|.|.....|||.:... .||.|...||.:.||::::. .
Human 184 ----------CGKSKEEKPGKSQSSRG--------------AKRDKDAGKSRKDKHDLLQG---H 221
Fly 502 QNGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSG 566
||| |||.:.||. || .|.|
Human 222 QNG------------------------------------SGSQAPSGG-------HL----YGFG 239
Fly 567 SSSSGGGSQNNASGHASGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASA 631
:.|:||| ||....||..|||. .::|...:...|.....|.|.|.|
Human 240 AKSNGGG----ASPFHCGGTGSGSV---------AAAGEVSKSAPDSGLMGNSMLVKK------- 284
Fly 632 AGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMS 696
|::..| || ||...:.. .
Human 285 --EEEEEE----------------------SH----RRIKKLKT--------------------E 301
Fly 697 AVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSSAGGVGGSGGGANAPGPPG 761
.|.| :|| || ||.||
Human 302 KVDP-LFT--------------VP-----------------------------------APPPP- 315
Fly 762 KESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMI 826
|||.:..|: ..:.:|.|.:| :.|| :
Human 316 --------ISSSLTPQI----LPSYFSPSSSN--------------------------IAAP--V 340
Fly 827 SATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPC 891
...:..|.||...| | .||.:|||:|||||
Human 341 EQLLVRTRSVGVNT---------------------------------C---EVGVVTEPECLGPC 369
Fly 892 EPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPRFCDSPTEELDSRTPKGR 956
||||||.||||||||||.||||||||||.|||||||||||:|||||||||:|||.:|:.|..:||
Human 370 EPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGR 434
Fly 957 GKRGRSAGLTP-DLSNFTETRSSIYFSHAQVHSKLRNGAT-KGRGATRSASG-----NAAANSNS 1014
|||.|||...| ..::|||:|. :.:|.|.||. |||..:.:||| |.||....
Human 435 GKRARSAAAAPGSEASFTESRG--------LQNKNRGGANGKGRRGSLNASGRRTPPNCAAEDIK 491
Fly 1015 SSSGNGGGATPSTSPTAFLPPRPEKRKSKDEAPSPLNGDASDGASVGGIGGAGGVNMVNASGIPI 1079
:| |....|||:|......||..:.| |..|..:
Human 492 AS-----------------PSSTNKRKNKPPMELDLNSSSED----------------NKPGKRV 523
Fly 1080 SASGGGLATQPQSLLNPVTGLNVQISTKKCKTASPCAISPVLLECPEQDCSKKYKHANGLRYHQS 1144
..:.....|.||. .|.|....| .|: ||||::||..:|:|||||.|||||||:
Human 524 RTNSRSTPTTPQG--KPETTFLDQ----------GCS-SPVLIDCPHPNCNKKYKHINGLRYHQA 575
Fly 1145 HAH----------------------GAGGGASSMDE--------DSMQAPEDPATPPSPGVASG- 1178
||| |....|....| |.::||..|.....||...|
Human 576 HAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGK 640
Fly 1179 -----TGSGASVASSAVPATAPSAG----QGTVAVSPNTPLANSSNPVTNGNVAPSAPA------ 1228
.|.|:.:.:.|...:....| ...:.|..|...|..|....:|::|...|.
Human 641 RELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGL 705
Fly 1229 -----TGSVTIAAPNTTPSVVETQAPLTGPPPVTP-PAPTPICAVATPGAEQSVSSVLPLGNLP- 1286
.|........|.....:..:.|....|:.| |||||...:|.|.|..:.::...:..||
Human 706 IDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPS 770
Fly 1287 LTAGPNSATQQQQPPTQQQQPQLLVPG------GSAASLQQQQQQQQ-------------PVAGG 1332
||.....|| .:.||.:..||:..:.| .:..||:.:::::: |....
Human 771 LTTTVVQAT-PKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDA 834
Fly 1333 SI---------TAGISGQALSQHQQQLMGGLPAMLSDQQQQALLQQGALKAGVLRFGPPDGNPLQ 1388
.: :..:.|..|..|..: ..||...||:.|:. :..::||...:......|...
Human 835 KLGKLEDSKGASKDLPGHFLKDHLNK-NEGLANGLSESQES---RMASIKAEADKVYTFTDNAPS 895
Fly 1389 QQPGQAS-------VNPQTQQSPPRPPSHVQDQQTPSAYAQQAGLKTSPGFGSVGVGAASSKQKK 1446
...|.|| ||.|. |..|.||..|. ||.||..|
Human 896 PSIGSASRLECSTLVNGQA----PMAPLHVLTQN----------------------GAESSAAK- 933
Fly 1447 NRKSPGPSDFEGRVSREDVQSPAYSDISD-------DSTPVAEQEMLDK--SVGQAVTAKHIELM 1502
..||||||||| || ..:.|..| |....:::|...:.
Human 934 ------------------TSSPAYSDISDAADDGGSDS---RSEGMRSKASSPSDIISSKDSVVK 977
Fly 1503 GKKPTEVGVGVPPPPAPNMYVPGMYQFYPAQQQSAPPPQQQQQQPQYMVQTEPGKPPGLPPALTQ 1567
|...|.. ..:|.:.:..|......|.|
Human 978 GHSSTTA--------------------QSSQLKESHSPYYHSYDPYY------------------ 1004
Fly 1568 AQQQQQLQPGAPPPTSQPPSHLLGPPGQQSVAAHLADYSGKNKDPPLDLMTKPQPQPGQPPSQQQ 1632
.||:: .||| |.|..|..||..:. .|.:.:..:...::.
Human 1005 -----------------SPSYM--HPGQ--VGAPAAGNSGSTQG------MKIKKESEEDAEKKD 1042
Fly 1633 QSGQLSGQENNGKDVGPPTSQPGSQPPPVNLSAVAGPPPGSLPPGLGGLSALGAAGLGGPGPGKG 1697
::.||..::
Human 1043 KAEQLDSKK-------------------------------------------------------- 1051
Fly 1698 MPHFYPFNFIPPAYPYNVDPNFGSVSIVASEEAAKLSGHPGLPPS-SQAQQLSGISIKEERLKES 1761
||.| |.|:....::.....||.|..| ...|...|:.:.::.|..:
Human 1052 -----------------VDHN--SASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMAT 1097
Fly 1762 PSPHDQPKHMPSQQQMIASKLIKQEPMTKQEIKQE-PNSNPGQQHPPPQQQPAPQPQQQQPPPPQ 1825
...:.|......:.|.:|.:.:.|......|.|.| |....|::....:..|: ....:.|..|:
Human 1098 SPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPS-ATISKAPSTPE 1161
Fly 1826 PQQPHALHPKDLQALGAYPAIYQRHSINLAVQQAREEELRRYYMFTGRQNSAAAAAAAAAQNAAS 1890
|.:.|: .|| |:: ..:.||..:..:.:..|....|.:..|.|
Human 1162 PNKNHS-------KLG--PSV-----------PNKTEETGKSQLLSNHQQQLQADSFKAKQ---- 1202
Fly 1891 GGLPPHPGMMHKDEPGMGSAAQQQQQQQQQQMQIAQQQQQAIQQHHQHLQQQHQAQQQQQQQQHQ 1955
:..| .:.|:...|.|.....:|.........:|...:...||...|.::..||:.::...:
Human 1203 --MENH--QLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDRE 1263
Fly 1956 QQQQQQQQQQQQQQQQQQQQKLKQSQAASAGANNKATNLT--KDSPKQKGGDDDQPL---KVKQE 2015
::.::...::...:: :|..:...:|| |:.||:....|.|.: |:|.:
Human 1264 KKLKEDSPRKTPNKE--------------SGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKND 1314
Fly 2016 GQKPTM---ETQGPPPPPTSQYFLHPSYIS-----PTPFGFDPNHPMYRNV----LMSAAGPYNT 2068
.:|..: :::|.....:|....|.|||. |.|..:||:||.||.| :.|..|.|.:
Human 1315 DRKTPVNWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLS 1379
Fly 2069 APYHLPIPRPYHAPEDLSR-------NTGT----KALDALHHAASQYYTTHKIHELSERALKSPT 2122
..:|.|:.......|:..: ||.| ||||.|...|:||.: |||
Human 1380 PGFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRS------------KSP- 1431
Fly 2123 SGSGPVKVSVSSPSIGPPQPGGPTSSGPGSGPVSGVLGPGSGSNQQPGSAPGSAGGVPLNLQPPP 2187
.||:.:
Human 1432 ---APVEKA-------------------------------------------------------- 1437
Fly 2188 GGMGPSPGSKPDLSGPKGHGGVTPGSSLDGHKQSMPGGPPPNGPSGNGAVGGVGGAAGNGAAGGG 2252
|.....:..::
Human 1438 ----------------------TAEREREAERE-------------------------------- 1448
Fly 2253 GAGAADSRSPPPQRHVHTHHHTHVGLGYPMYPAPY-------GAAVLASQQAAAVAVINPFPPG 2309
.|..||..|||:|||||||||:|||:.|..| .||::||||.||.|..:...||
Human 1449 ----RDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQASASGMFPG 1508
| 
