DRSC/TRiP Functional Genomics Resources

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Protein Alignment sbb and ZNF608

DIOPT Version :9

Sequence 1:NP_001261074.1 Gene:sbb / 44027 FlyBaseID:FBgn0285917 Length:2330 Species:Drosophila melanogaster
Sequence 2:NP_001372548.1 Gene:ZNF608 / 57507 HGNCID:29238 Length:1512 Species:Homo sapiens


Alignment Length:2339 Identity:505/2339 - (21%)
Similarity:729/2339 - (31%) Gaps:979/2339 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 SSSLSSSSSSNSSESKDTNFEYEDEWNIGGIPELLDDLDADIEKSAHSSGGGNQATALNAKQANS 182
            |.::|::.......:.|| ::..|:|.| |:..|:.|||||:||.       .|...:|    ||
Human     2 SVNISTAGKGVDPNTVDT-YDSGDDWEI-GVGNLIIDLDADLEKD-------RQKFEMN----NS 53

  Fly   183 SSTSSSSSSKGGASSSSSSAAATGSSSSHKSHKTTLHSNLSATSPTTIKFTRQPVAIGGANSSSS 247
            ::|:|||:||.....:||.|.||                  |.....:||              :
Human    54 TTTTSSSNSKDCGGPASSGAGAT------------------AALADGLKF--------------A 86

  Fly   248 SSAAAAPSGGSANVVAKGSSSSSSSTSSSSSGKHHHHHHHHSNSSSSGSSSKGYKSALVAQLNSP 312
            |..|:||.|.|                            |...|.|....||..|.         
Human    87 SVQASAPQGNS----------------------------HKETSKSKVKRSKTSKD--------- 114

  Fly   313 SPLNSNSKSLSGSGSGSGNTNGAAGAGAGSTLSSSTFAGFSKGGSLVSSSAGAAAALAAGSGQ-- 375
                                       |..:|.|:...|..:    :||:         |..|  
Human   115 ---------------------------ANKSLPSAALYGIPE----ISST---------GKRQEV 139

  Fly   376 QGSKFSAGGMSSQTG----SGSGGNNTSNSNNSSSGSGGSGSGSSTGNTASGSGNNNSTSAGGPP 436
            ||....|.||:|..|    ||..||..|||.::|:.:..:|:||                     
Human   140 QGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGS--------------------- 183

  Fly   437 SSQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQ 501
                      .|.|.....|||.:...              .||.|...||.:.||::::.   .
Human   184 ----------CGKSKEEKPGKSQSSRG--------------AKRDKDAGKSRKDKHDLLQG---H 221

  Fly   502 QNGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSG 566
            |||                                    |||.:.||.       ||    .|.|
Human   222 QNG------------------------------------SGSQAPSGG-------HL----YGFG 239

  Fly   567 SSSSGGGSQNNASGHASGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASA 631
            :.|:|||    ||....||..|||.         .::|...:...|.....|.|.|.|       
Human   240 AKSNGGG----ASPFHCGGTGSGSV---------AAAGEVSKSAPDSGLMGNSMLVKK------- 284

  Fly   632 AGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMS 696
              |::..|                      ||    ||...:..                    .
Human   285 --EEEEEE----------------------SH----RRIKKLKT--------------------E 301

  Fly   697 AVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSSAGGVGGSGGGANAPGPPG 761
            .|.| :||              ||                                   ||.|| 
Human   302 KVDP-LFT--------------VP-----------------------------------APPPP- 315

  Fly   762 KESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMI 826
                    |||.:..|:    ..:.:|.|.:|                          :.||  :
Human   316 --------ISSSLTPQI----LPSYFSPSSSN--------------------------IAAP--V 340

  Fly   827 SATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPC 891
            ...:..|.||...|                                 |   .||.:|||:|||||
Human   341 EQLLVRTRSVGVNT---------------------------------C---EVGVVTEPECLGPC 369

  Fly   892 EPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPRFCDSPTEELDSRTPKGR 956
            ||||||.||||||||||.||||||||||.|||||||||||:|||||||||:|||.:|:.|..:||
Human   370 EPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGR 434

  Fly   957 GKRGRSAGLTP-DLSNFTETRSSIYFSHAQVHSKLRNGAT-KGRGATRSASG-----NAAANSNS 1014
            |||.|||...| ..::|||:|.        :.:|.|.||. |||..:.:|||     |.||....
Human   435 GKRARSAAAAPGSEASFTESRG--------LQNKNRGGANGKGRRGSLNASGRRTPPNCAAEDIK 491

  Fly  1015 SSSGNGGGATPSTSPTAFLPPRPEKRKSKDEAPSPLNGDASDGASVGGIGGAGGVNMVNASGIPI 1079
            :|                 |....|||:|......||..:.|                |..|..:
Human   492 AS-----------------PSSTNKRKNKPPMELDLNSSSED----------------NKPGKRV 523

  Fly  1080 SASGGGLATQPQSLLNPVTGLNVQISTKKCKTASPCAISPVLLECPEQDCSKKYKHANGLRYHQS 1144
            ..:.....|.||.  .|.|....|          .|: ||||::||..:|:|||||.|||||||:
Human   524 RTNSRSTPTTPQG--KPETTFLDQ----------GCS-SPVLIDCPHPNCNKKYKHINGLRYHQA 575

  Fly  1145 HAH----------------------GAGGGASSMDE--------DSMQAPEDPATPPSPGVASG- 1178
            |||                      |....|....|        |.::||..|.....||...| 
Human   576 HAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGK 640

  Fly  1179 -----TGSGASVASSAVPATAPSAG----QGTVAVSPNTPLANSSNPVTNGNVAPSAPA------ 1228
                 .|.|:.:.:.|...:....|    ...:.|..|...|..|....:|::|...|.      
Human   641 RELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGL 705

  Fly  1229 -----TGSVTIAAPNTTPSVVETQAPLTGPPPVTP-PAPTPICAVATPGAEQSVSSVLPLGNLP- 1286
                 .|........|.....:..:.|....|:.| |||||...:|.|.|..:.::...:..|| 
Human   706 IDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPS 770

  Fly  1287 LTAGPNSATQQQQPPTQQQQPQLLVPG------GSAASLQQQQQQQQ-------------PVAGG 1332
            ||.....|| .:.||.:..||:..:.|      .:..||:.::::::             |....
Human   771 LTTTVVQAT-PKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDA 834

  Fly  1333 SI---------TAGISGQALSQHQQQLMGGLPAMLSDQQQQALLQQGALKAGVLRFGPPDGNPLQ 1388
            .:         :..:.|..|..|..: ..||...||:.|:.   :..::||...:......|...
Human   835 KLGKLEDSKGASKDLPGHFLKDHLNK-NEGLANGLSESQES---RMASIKAEADKVYTFTDNAPS 895

  Fly  1389 QQPGQAS-------VNPQTQQSPPRPPSHVQDQQTPSAYAQQAGLKTSPGFGSVGVGAASSKQKK 1446
            ...|.||       ||.|.    |..|.||..|.                      ||.||..| 
Human   896 PSIGSASRLECSTLVNGQA----PMAPLHVLTQN----------------------GAESSAAK- 933

  Fly  1447 NRKSPGPSDFEGRVSREDVQSPAYSDISD-------DSTPVAEQEMLDK--SVGQAVTAKHIELM 1502
                              ..|||||||||       ||   ..:.|..|  |....:::|...:.
Human   934 ------------------TSSPAYSDISDAADDGGSDS---RSEGMRSKASSPSDIISSKDSVVK 977

  Fly  1503 GKKPTEVGVGVPPPPAPNMYVPGMYQFYPAQQQSAPPPQQQQQQPQYMVQTEPGKPPGLPPALTQ 1567
            |...|..                    ..:|.:.:..|......|.|                  
Human   978 GHSSTTA--------------------QSSQLKESHSPYYHSYDPYY------------------ 1004

  Fly  1568 AQQQQQLQPGAPPPTSQPPSHLLGPPGQQSVAAHLADYSGKNKDPPLDLMTKPQPQPGQPPSQQQ 1632
                             .||::  .|||  |.|..|..||..:.      .|.:.:..:...::.
Human  1005 -----------------SPSYM--HPGQ--VGAPAAGNSGSTQG------MKIKKESEEDAEKKD 1042

  Fly  1633 QSGQLSGQENNGKDVGPPTSQPGSQPPPVNLSAVAGPPPGSLPPGLGGLSALGAAGLGGPGPGKG 1697
            ::.||..::                                                        
Human  1043 KAEQLDSKK-------------------------------------------------------- 1051

  Fly  1698 MPHFYPFNFIPPAYPYNVDPNFGSVSIVASEEAAKLSGHPGLPPS-SQAQQLSGISIKEERLKES 1761
                             ||.|  |.|:....::.....||.|..| ...|...|:.:.::.|..:
Human  1052 -----------------VDHN--SASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMAT 1097

  Fly  1762 PSPHDQPKHMPSQQQMIASKLIKQEPMTKQEIKQE-PNSNPGQQHPPPQQQPAPQPQQQQPPPPQ 1825
            ...:.|......:.|.:|.:.:.|......|.|.| |....|::....:..|: ....:.|..|:
Human  1098 SPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPS-ATISKAPSTPE 1161

  Fly  1826 PQQPHALHPKDLQALGAYPAIYQRHSINLAVQQAREEELRRYYMFTGRQNSAAAAAAAAAQNAAS 1890
            |.:.|:       .||  |::           ..:.||..:..:.:..|....|.:..|.|    
Human  1162 PNKNHS-------KLG--PSV-----------PNKTEETGKSQLLSNHQQQLQADSFKAKQ---- 1202

  Fly  1891 GGLPPHPGMMHKDEPGMGSAAQQQQQQQQQQMQIAQQQQQAIQQHHQHLQQQHQAQQQQQQQQHQ 1955
              :..|  .:.|:...|.|.....:|.........:|...:...||...|.::..||:.::...:
Human  1203 --MENH--QLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDRE 1263

  Fly  1956 QQQQQQQQQQQQQQQQQQQQKLKQSQAASAGANNKATNLT--KDSPKQKGGDDDQPL---KVKQE 2015
            ::.::...::...::              :|..:...:||  |:.||:....|.|.:   |:|.:
Human  1264 KKLKEDSPRKTPNKE--------------SGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKND 1314

  Fly  2016 GQKPTM---ETQGPPPPPTSQYFLHPSYIS-----PTPFGFDPNHPMYRNV----LMSAAGPYNT 2068
            .:|..:   :::|.....:|....|.|||.     |.|..:||:||.||.|    :.|..|.|.:
Human  1315 DRKTPVNWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLS 1379

  Fly  2069 APYHLPIPRPYHAPEDLSR-------NTGT----KALDALHHAASQYYTTHKIHELSERALKSPT 2122
            ..:|.|:.......|:..:       ||.|    ||||.|...|:||.:            ||| 
Human  1380 PGFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRS------------KSP- 1431

  Fly  2123 SGSGPVKVSVSSPSIGPPQPGGPTSSGPGSGPVSGVLGPGSGSNQQPGSAPGSAGGVPLNLQPPP 2187
               .||:.:                                                        
Human  1432 ---APVEKA-------------------------------------------------------- 1437

  Fly  2188 GGMGPSPGSKPDLSGPKGHGGVTPGSSLDGHKQSMPGGPPPNGPSGNGAVGGVGGAAGNGAAGGG 2252
                                  |.....:..::                                
Human  1438 ----------------------TAEREREAERE-------------------------------- 1448

  Fly  2253 GAGAADSRSPPPQRHVHTHHHTHVGLGYPMYPAPY-------GAAVLASQQAAAVAVINPFPPG 2309
                .|..||..|||:|||||||||:|||:.|..|       .||::||||.||.|..:...||
Human  1449 ----RDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQASASGMFPG 1508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sbbNP_001261074.1 PRK10856 <1143..>1245 CDD:236776 27/152 (18%)
ZNF608NP_001372548.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..74 12/31 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..237 59/319 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..295 11/78 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..545 50/170 (29%)
SFP1 <512..593 CDD:227516 32/109 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 622..665 9/42 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..750 9/36 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..858 12/81 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..996 23/134 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1066 16/137 (12%)
PTZ00108 <1103..1317 CDD:240271 44/256 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1192 17/95 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1335 19/128 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1423..1459 13/165 (8%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142490
Domainoid 1 1.000 305 1.000 Domainoid score I1372
eggNOG 1 0.900 - - E1_28KDT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 305 1.000 Inparanoid score I2649
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004207
OrthoInspector 1 1.000 - - otm41785
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR21564
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4982
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.970

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