DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbb and Zfp608

DIOPT Version :9

Sequence 1:	NP_001261074.1	Gene:	sbb / 44027	FlyBaseID:	FBgn0285917	Length:	2330	Species:	Drosophila melanogaster
Sequence 2:	NP_001100848.2	Gene:	Zfp608 / 307296	RGDID:	1306824	Length:	1513	Species:	Rattus norvegicus

Alignment Length:	2385	Identity:	513/2385 - (21%)
Similarity:	725/2385 - (30%)	Gaps:	1086/2385 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 SSSLSSSSSSNSSESKDTNFEYEDEWNIGGIPELLDDLDADIEKSAHSSGGGNQATALNAKQANS 182
            |.::|::.......:.|| ::..|:|.| |:..|:.|||||:||.       .|...:|    ||
  Rat     2 SVNVSTAGKGVDPNTVDT-YDSGDDWEI-GVGNLIIDLDADLEKD-------RQKFEMN----NS 53

  Fly   183 SSTSSSSSSKGGASSSSSSAAATGSSSSHKSHKTTLHSNLSATSPTTIKFTRQPVAIGGANSSSS 247
            ::|:::::...|..:|:.:.|.:..:..                   :||              :
  Rat    54 TNTTTNNTKDCGGPASNGTCATSALADG-------------------LKF--------------A 85

  Fly   248 SSAAAAPSGGSANVVAKGSSSSSSSTSSSSSGKHHHHHHHHSNSSSSGSSSKGYKSALVAQLNSP 312
            |...:||.|.|                            |...|.|....:|..|.
  Rat    86 SVQPSAPQGNS----------------------------HKETSKSKVKRAKTSKD--------- 113

  Fly   313 SPLNSNSKSLSGSGSGSGNTNGAAGAGAGSTLSSSTFAGFSKGGSLVSSSAGAAAALAAGSGQ-- 375
                                       |..:|.|:...|..:              ::.|..|
  Rat   114 ---------------------------ANKSLPSAALYGIPE--------------ISTGKRQEV 137

  Fly   376 QGSKFSAGGMSSQTG---SGSGGNNTSNSNNSSSGSGGSGSGSSTGNTASGSGNNNSTSAGGPPS 437
            ||....|.||:|..|   ||.||.| .|||           |:|||.:|:.:|      ||
  Rat   138 QGRPGEATGMNSALGQSVSGGGGGN-PNSN-----------GTSTGTSAATAG------AG---- 180

  Fly   438 SQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQQ 502
                    ..|.|.....|||.:...              .||.|...:|.:.||::::.   .|
  Rat   181 --------SCGKSKEEKPGKSHSSRG--------------AKRDKDAARSRKDKHDVLQG---HQ 220

  Fly   503 NGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSGS 567
            ||  |.|       .|.||..                                 ||    .|.|:
  Rat   221 NG--GGG-------QGPSGGG---------------------------------HL----YGFGA 239

  Fly   568 SSSGGGSQNNASGHASGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASAA 632
            .|:|.|    ||....||..|||.         |::|...:...|.....|.|.|.|
  Rat   240 KSNGSG----ASPFHCGGAGSGSV---------GAAGEVTKTAPDSTLMGNSMLVKK-------- 283

  Fly   633 GEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMSA 697
             |::..|                      ||    ||...:..                    ..
  Rat   284 -EEEEEE----------------------SH----RRIKKLKT--------------------EK 301

  Fly   698 VPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSSAGGVGGSGGGANAPGPPGK 762
            |.| :||              ||                                   ||.||
  Rat   302 VDP-LFT--------------VP-----------------------------------APPPP-- 314

  Fly   763 ESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMIS 827
                       ||:.||.....:.:|.|.:|                          :.||  :.
  Rat   315 -----------IASSLAPQIPPSYFSPSSSN--------------------------IAAP--VE 340

  Fly   828 ATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPCE 892
            ..:..|.||...|                                 |   .||.:|||:||||||
  Rat   341 QLLVRTRSVGVNT---------------------------------C---EVGVVTEPECLGPCE 369

  Fly   893 PGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPRFCDSPTEELDSRTPKGRG 957
            |||||.||||||||||.||||||||||.|||||||||||:|||||||||:|||.:|:.|..:|||
  Rat   370 PGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGRG 434

  Fly   958 KRGRSAGLTPDLS-NFTETRSSIYFSHAQVHSKLRNGAT-KGRGATRSASG-----NAAANSNSS 1015
            ||.|||...|... :|||:|.        :.||.|.||. |||..:.:|||     |.||....:
  Rat   435 KRARSAAAAPGAEVSFTESRG--------LQSKNRGGANGKGRRGSLNASGRRTPPNCAAEDVKA 491

  Fly  1016 SSGNGGGATPSTSPTAFLPPRPEKRKSKDEAPSPLNGDASDGASVGGIGGAGGVNMVNASGIPIS 1080
            |                 |....|||:|......||..:.|                :..|..:.
  Rat   492 S-----------------PSSTNKRKNKPPMELDLNSSSED----------------SKPGKRVR 523

  Fly  1081 ASGGGLATQPQSLLNPVTGLNVQISTKKCKTASPCAISPVLLECPEQDCSKKYKHANGLRYHQSH 1145
            .:.....|.||.  .|.|....|          .|: ||||::||..:|:|||||.|||||||:|
  Rat   524 TNSRSTPTTPQG--KPETTFLDQ----------GCS-SPVLIDCPHPNCNKKYKHINGLRYHQAH 575

  Fly  1146 AH-----------GAGGGASSMDE-------------------DSMQAPEDPATPPSPGVASG-- 1178
            ||           .:....|..:|                   |.::||..|.....||...|
  Rat   576 AHLDPENKLEFEPDSEDKISDCEEALSNVALDCNEPSTSVSSYDQVKAPGSPGAGNPPGTPKGKR 640

  Fly  1179 ----TGSGASVASSAVPATAPSAGQGTVAVSPNTPLANSSNPVTNGNVAP---SAPATGSVTIAA 1236
                .|.|..:.|.    |..::|:..   ..|..|:|.  ||.:...|.   .:.|.||:....
  Rat   641 EHVSNGPGPIIGSK----TGKNSGKKR---GLNNELSNL--PVISNMTATVDICSAADGSLAAEM 696

  Fly  1237 PN-TTPSVVETQ--------------------APLTGPPPVTP-PAPTPICAVATPGAEQSVSSV 1279
            |. ....:::.:                    :.|....|:.| |||||...:|.|.|..:.::.
  Rat   697 PKLEAEGLIDKKSLGDKEKGKKANNCKMDKNLSKLKSARPIAPAPAPTPPQLIAIPTAAFTSTTT 761

  Fly  1280 LPLGNLP-LTAGPNSATQQQQPPTQQQQPQLLVPG------GSAASLQQQQQQQQ---PVAGGSI 1334
            ..:..|| ||.....|| .:.||.:..||:..:.|      .:..||:.::::::   ....|..
  Rat   762 GTIPGLPSLTTTVVQAT-PKSPPLKPIQPKPTIMGEPITVNPALVSLKDRKKKEKRKLKDKEGKD 825

  Fly  1335 TAG-------------------ISGQALSQHQQQLMG---GLPAMLSDQQQQALLQQGALKAGVL 1377
            |.|                   :||..|..|    :|   ||...||:.|:.   :..::||...
  Rat   826 TGGPKMDSKLGKLEDAKVASKDLSGHFLKDH----LGKSEGLANGLSESQES---RMASIKAEAD 883

  Fly  1378 RFGPPDGNPLQQQPGQAS-------VNPQTQQSPPRPPSHVQDQQTPSAYAQQAGLKTSPGFGSV 1435
            :......|......|.||       ||.|.    |..|.||..|..    |:.|..|||
  Rat   884 KVYTFTDNAPSPSIGSASRMECSTLVNGQA----PMAPLHVLTQNG----AESAAAKTS------ 934

  Fly  1436 GVGAASSKQKKNRKSPGPSDFEGRVSREDVQSPAYSDISDDSTPVAEQEMLDKSVGQAVTAKHIE 1500
                                           |||||||||     |..:....|..:.:.:|
  Rat   935 -------------------------------SPAYSDISD-----AADDGGSDSRSEGMRSK--- 960

  Fly  1501 LMGKKPTEVGVGVPPPPAPNMYVPGMYQFYPAQQQSAPPPQQQQQQPQYMVQTEPGKPPGLPPAL 1565
              ...|:|....          ..|:.:.:|  |.||.|.|.::....|....||
  Rat   961 --ASSPSETFSN----------KDGVVKGHP--QTSAQPSQLKESHSPYYHGYEP---------- 1001

  Fly  1566 TQAQQQQQLQPGAPPPTSQPPSHLLGPPGQQSVAAHLADYSGKNKDPPLDLMTKPQPQPGQPPSQ 1630
                             ...||::                                 .|||
  Rat  1002 -----------------YYSPSYM---------------------------------HPGQ---- 1012

  Fly  1631 QQQSGQLSGQENNGKDVGPPTSQPGSQPPPVNLSAVAGPPPGSLPPGLGGLSALGAAGLGGPGPG 1695
                            ||.|                                   |||.||...|
  Rat  1013 ----------------VGAP-----------------------------------AAGNGGSAQG 1026

  Fly  1696 KGMPHFYPFNFIPPAYPYNVDPNFGSVSIVASEEAAKLSGHPGLPPSSQAQQLSGISIKEERLKE 1760
            .                        .:...:.|:|.|         ..:|:||      |.:..|
  Rat  1027 M------------------------KIKKESEEDAEK---------KDKAEQL------ESKKAE 1052

  Fly  1761 SPSPHDQPKHMPSQQQMIASKLIKQEPMTKQEIKQEPNSNPGQQHPPPQQQPAPQPQQQQPPPPQ 1825
            .||...||:|    |.:|.                       |:||...|...           .
  Rat  1053 HPSASLQPQH----QSVIT-----------------------QRHPALAQSLY-----------Y 1079

  Fly  1826 PQQPHALHPKDLQALGAYPAIYQRHSINLAVQQAREEELRRYYMFTGR----------------- 1873
            .|..:.|:......:...||..|::......|:..|::|.:    :||
  Rat  1080 GQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKLAQ----SGRGDCERKAELPLKELGKE 1140

  Fly  1874 ---QNSAAAAAAAAAQNAASGGLPPHPGMMHK----------DEPGMGSAAQQQQQQQQQQMQIA 1925
               |.:..:|..:.|.:.      |.|...|.          :|.|........|||.|.....|
  Rat  1141 DSKQKNIPSATVSKAPST------PEPNKNHSKVGPSVPNKTEETGKSQLLSSHQQQLQADSFKA 1199

  Fly  1926 QQQQQAIQQHHQHLQQQHQ-------------------AQQQQQQQQHQQQQQQQQQQQQQQQQQ 1971
            :|     .::||.:::..:                   .|..:.:..|....|.:...||:.::.
  Rat  1200 KQ-----MENHQLIKEAVEMKSVMDSMKQTGVDPASRFKQDPESRTWHHYVYQPKYLDQQKPEEL 1259

  Fly  1972 QQQQKLKQSQA-----ASAGANNKATNLT--KDSPKQKGGDDDQPL---KVKQEGQKPTM---ET 2023
            .:::|||:...     ..:|..:...:||  |:.||.....|.|.:   |:|.|.:|..:   ::
  Rat  1260 DREKKLKEDSPRKTPNKESGTPSLPVSLTNIKEEPKDGKRPDSQSVEESKLKNEDRKTPVNWKDS 1324

  Fly  2024 QGPPPPPTSQYFLHPSYIS-----PTPFGFDPNHPMYRNV----LMSAAGPYNTAPYHLPIPRPY 2079
            :|.....:|....|.|||.     |.|..:||:||.||.|    :.|..|.|.:..:|.|:....
  Rat  1325 RGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSPGFHYPVYGKM 1389

  Fly  2080 HAPEDLSR-NTG----------TKALDALHHAASQYYTTHKIHELSERALKSPTSGSGPVKVSVS 2133
            ...|:..: ||.          .||||.|.|.|:||.:            |||    .||:
  Rat  1390 SGREEAEKVNTSPSISTKTASEAKALDLLQHHANQYRS------------KSP----APVE---- 1434

  Fly  2134 SPSIGPPQPGGPTSSGPGSGPVSGVLGPGSGSNQQPGSAPGSAGGVPLNLQPPPGGMGPSPGSKP 2198
                                       ..|...::...|...
  Rat  1435 ---------------------------KASTEREREREAERE----------------------- 1449

  Fly  2199 DLSGPKGHGGVTPGSSLDGHKQSMPGGPPPNGPSGNGAVGGVGGAAGNGAAGGGGAGAADSRSPP 2263
                                                                      .|..||.
  Rat  1450 ----------------------------------------------------------RDRHSPF 1456

  Fly  2264 PQRHVHTHHHTHVGLGYPMYPAPY-------GAAVLASQQAAAVA 2301
            .|||:|||||||||:|||:.|..|       .||::||||.||.|
  Rat  1457 SQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQA 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbb	NP_001261074.1	PRK10856	<1143..>1245	CDD:236776	28/141 (20%)
Zfp608	NP_001100848.2	SFP1	<511..592	CDD:227516	31/109 (28%)
Zfp608	NP_001100848.2	PTZ00108	<1102..1320	CDD:240271	42/232 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335994
Domainoid	1	1.000	288	1.000	Domainoid score	I1510
eggNOG	1	0.900	-	-		E1_28KDT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2740
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004207
OrthoInspector	1	1.000	-	-		otm45923
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21564
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980