DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbb and ZNF609

DIOPT Version :9

Sequence 1:	NP_001261074.1	Gene:	sbb / 44027	FlyBaseID:	FBgn0285917	Length:	2330	Species:	Drosophila melanogaster
Sequence 2:	NP_055857.1	Gene:	ZNF609 / 23060	HGNCID:	29003	Length:	1411	Species:	Homo sapiens

Alignment Length:	1900	Identity:	431/1900 - (22%)
Similarity:	632/1900 - (33%)	Gaps:	707/1900 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 GSSSSSGSSSSSSKKHLNNASSGSG--SSSSGGGSQNNASGHASGGGSSGS--SQSTPQGTKRGS 602
            |....|.|..|.|.|..:..:.|:.  :.|.|..|:....|.:..|.::|.  :...|:|:::.:
Human    83 GKEGKSKSKRSKSGKDTSKPTPGTSLFTPSEGAASKKEVQGRSGDGANAGGLVAAIAPKGSEKAA 147

  Fly   603 SGHRREKTKDKNAHSNRMSVDKSAAAASAAGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACI 667
            .                       |:.|.||.|...|
Human   148 K-----------------------ASRSVAGSKKEKE---------------------------- 161

  Fly   668 RRAAHMSNSAGNANSSAGTGQSGGSSSMSAVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAA 732
                       |::|.:...:|.|..:.|...|||..|             ||
Human   162 -----------NSSSKSKKERSEGVGTCSEKDPGVLQP-------------VP------------ 190

  Fly   733 SSSASQMASSSAGGVGGSGGGANAPGPPGKESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQG 797
                       .||.||...|:........|..|||.|.        ..||.|.. |:.....:|
Human   191 -----------LGGRGGQYDGSAGVDTGAVEPLGSIAIE--------PGAALNPL-GTKPEPEEG 235

  Fly   798 QNSNAGGNGGSESKAAAAAQA-KLMAPGMISATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGA 861
            :|         |.:.....:: |:.:|....|.:...:.||    ..::|..| |.:::.....:
Human   236 EN---------ECRLLKKVKSEKMESPVSTPAVLPIHLLVP----VVNNDISS-PCEQIMVRTRS 286

  Fly   862 SGAGGGKEMVDICIGTSVGTITEPDCLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGT 926
            .|       |:.|   .|...|||:|||||||||||.||||||.|||.|:||||||||.||||||
Human   287 VG-------VNTC---DVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGT 341

  Fly   927 LLDCTRHDWAPPRFCDSPTEELDSRTPKGRGKRGRSAGLTPDLSNFTETRSSIYFSHAQVHSKLR 991
            |||||||||||||||||||.:|:.|..:|||||.|....||    ..||.::.........||.|
Human   342 LLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPNSNTP----VNETATASDSKGTSNSSKTR 402

  Fly   992 NGA-TKGRGATRSASGNAAANSNSSSSGNGGGATPSTSPTAFLPPRPEKRKSKDEAPSPLNGDAS 1055
            .|| :|||..::::|.:....|::|....   |:||::         .|||:|..:...||..:.
Human   403 AGANSKGRRGSQNSSEHRPPASSTSEDVK---ASPSSA---------NKRKNKPLSDMELNSSSE 455

  Fly  1056 DGASVGGIGGAGGVNMVNASGIPISASGGGLATQPQSLLNPVTGLNVQ--ISTKKCKTASPCAIS 1118
            |..      |:..|. .|:.|   ||:|            |:.|..|:  :..:.|.       |
Human   456 DSK------GSKRVR-TNSMG---SATG------------PLPGTKVEPTVLDRNCP-------S 491

  Fly  1119 PVLLECPEQDCSKKYKHANGLRYHQSHAHGAGGGASSMDEDSMQAPEDPATPPSPGVASGTGSGA 1183
            |||::||..:|:|||||.|||:|||:|||.........|.||....|     |......|:.:||
Human   492 PVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEE-----PILHADLGSCNGA 551

  Fly  1184 SVASSAVPATAPSAGQGTVAVSPNTPLANSSNPVTNGNVAPSAPATGSVTIAA-----PNTTPSV 1243
            ||:.....:.|.||......|.|::| :.||...|.|.........|...:.|     .:..|||
Human   552 SVSQKGSLSPARSATPKVRLVEPHSP-SPSSKFSTKGLCKKKLSGEGDTDLGALSNDGSDDGPSV 615

  Fly  1244 VETQA-------------------------------PLTGPPPVTPPAP--------TPICAVAT 1269
            ::..:                               .|....|:.|..|        |.....|:
Human   616 MDETSNDAFDSLERKCMEKEKCKKPSSLKPEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAAS 680

  Fly  1270 PGAEQSVSSVLPLGNLPLTAGPNSATQQ--QQPPTQQQQPQLLVPGGSAA---------SLQQQQ 1323
            ||:...:::.:      ..|.|||...:  |..||...:|..:.|..:.|         ..:..:
Human   681 PGSSSGLTATV------AQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKESSK 739

  Fly  1324 QQQQPVAGGSITAGISGQA---LSQHQQQLMGGLPAMLSDQQQQALLQQGALKAGVLRFGPPDGN 1385
            :.:.|:..|.:.....|::   .|......|.||....||..|..|   .::||...:......|
Human   740 ELESPLTPGKVCRAEEGKSPFRESSGDGMKMEGLLNGSSDPHQSRL---ASIKAEADKIYSFTDN 801

  Fly  1386 PLQQQPGQASVNPQTQQSPPRPPSHVQDQQTPSAYAQQAGLKTSPGFGSVGVGAASSKQKKNRKS 1450
            ......|.:|....|..:.|..|.||..|.                      ||.:|..|.|
Human   802 APSPSIGGSSRLENTTPTQPLTPLHVVTQN----------------------GAEASSVKTN--- 841

  Fly  1451 PGPSDFEGRVSREDVQSPAYSDISD---------DSTPVAEQEMLDKSVGQAVTAKHIELMGKKP 1506
                            |||||||||         ||....:.|.|.|.             |.|.
Human   842 ----------------SPAYSDISDAGEDGEGKVDSVKSKDAEQLVKE-------------GAKK 877

  Fly  1507 TEVGVGVPPPPAPNMYVPGMYQFYPAQQQSAPPPQQQQQQPQYMVQTEPGKPPGLPPALTQAQQQ 1571
            |                     .:|.|.||...|..|..:..|            .|:..|:
Human   878 T---------------------LFPPQPQSKDSPYYQGFESYY------------SPSYAQS--- 906

  Fly  1572 QQLQPGAPPPTSQPPSHLLGPPGQQSVAAHLADYSGKNKDPPLDLMTKPQPQPGQPPSQQQQSGQ 1636
               .|||..|:||        .|.:|.|                |.||...:|          ..
Human   907 ---SPGALNPSSQ--------AGVESQA----------------LKTKRDEEP----------ES 934

  Fly  1637 LSGQENNG--KDVGPPTSQPGSQPPPVNLSAVAGPPPGSLPPGLGGLSALGAAGLGGPGPGKGMP 1699
            :.|:..|.  ::..|..|....||      :|....|......|
Human   935 IEGKVKNDICEEKKPELSSSSQQP------SVIQQRPNMYMQSL--------------------- 972

  Fly  1700 HFYPFNFIPPAYPYNVDPNFGSVSIVASEEAAKLSGHPGLPPSSQAQQLSGISIKEER-LKESPS 1763
            ::..:.::|| |.|: |.:: ...::::..|.:..........|..||..|:..|.|. |||
Human   973 YYNQYAYVPP-YGYS-DQSY-HTHLLSTNTAYRQQYEEQQKRQSLEQQQRGVDKKAEMGLKE--- 1031

  Fly  1764 PHDQPKHMPSQQQMIASKLIKQEPMTKQEIKQEPNSNPGQQHPPPQQQPAPQ--------PQQQQ 1820
                                 :|...|:|.||:|:.       ||....||.        |.:.:
Human  1032 ---------------------REAALKEEWKQKPSI-------PPTLTKAPSLTDLVKSGPGKAK 1068

  Fly  1821 PPPPQPQQPHALHPK--DLQAL-GAYPAIYQRHSINLAVQQAREEELRRYYMFTGRQNSAAAAAA 1882
            .|...|.: ..:.||  |...| |..|     ..:.:.:..|                |..:..|
Human  1069 EPGADPAK-SVIIPKLDDSSKLPGQAP-----EGLKVKLSDA----------------SHLSKEA 1111

  Fly  1883 AAAQNAASGGLPPHPGMMHKDEPGMGSAAQQQQQQQQQQMQIAQQQQQAIQQHHQHLQQQHQAQQ 1947
            :.|:..|..|                        :|.:...|...:|:|               :
Human  1112 SEAKTGAECG------------------------RQAEMDPILWYRQEA---------------E 1137

  Fly  1948 QQQQQQHQQQQQQQQQQQQQQQQQQQQQKLKQSQAASAGANNKATNLTKDS-PKQKGGD---DDQ 2008
            .:........:....:.:.::.::::.:|||:.::.|           ||| ||:.|.:   .|.
Human  1138 PRMWTYVYPAKYSDIKSEDERWKEERDRKLKEERSRS-----------KDSVPKEDGKESTSSDC 1191

  Fly  2009 PLKVKQEGQKPTMETQGPPP----PPTSQYFLHPSYISPTPF--------GFDPNHPMYRN---- 2057
            .|...:|.:..:.|   |.|    |.:|....|.|||   |:        .:|||||.||:
Human  1192 KLPTSEESRLGSKE---PRPSVHVPVSSPLTQHQSYI---PYMHGYSYSQSYDPNHPSYRSMPAV 1250

  Fly  2058 VLMSAAGPYNTAPYHLPIPRPYHAP----EDLSR-----------NTGTKALDALHHAASQYYTT 2107
            ::.:..|.|..:.|..   .||.:.    ||..:           ::.:||||.|...||.|.:
Human  1251 MMQNYPGSYLPSSYSF---SPYGSKVSGGEDADKARASPSVTCKSSSESKALDILQQHASHYKS- 1311

  Fly  2108 HKIHELSERALKSPTSGSGPVKVSVSSPSIGPPQPGGPTSSGPGSGPVSGVLGPGSGSNQQPGSA 2172
                       ||||         :|..:
Human  1312 -----------KSPT---------ISDKT------------------------------------ 1320

  Fly  2173 PGSAGGVPLNLQPPPGGMGPSPGSKPDLSGPKGHGGVTPGSSLDGHKQSMPGGPPPNGPSGNGAV 2237
                                        |..:..||.                         |.|
Human  1321 ----------------------------SQERDRGGC-------------------------GVV 1332

  Fly  2238 GGVGGAAGNGAAGGGGAGAADSRSPPPQRHVHTHHHTHVGLGYPMYPA----PYGA-----AVLA 2293
            ||.|..:..|.|.||.......|:.|.||.:.||||.| .|||.:.||    ||.|     |::|
Human  1333 GGGGSCSSVGGASGGERSVDRPRTSPSQRLMSTHHHHH-HLGYSLLPAQYNLPYAAGLSSTAIVA 1396

  Fly  2294 SQQAAAVAVINPFPP 2308
            |||.:..::   :||
Human  1397 SQQGSTPSL---YPP 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbb	NP_001261074.1	PRK10856	<1143..>1245	CDD:236776	29/106 (27%)
ZNF609	NP_055857.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..190		30/181 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..484		51/168 (30%)
		SFP1	<412..533	CDD:227516	46/161 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..659		29/147 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..963		86/425 (20%)
		PTZ00121	<1002..>1200	CDD:173412	51/300 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1005..1125		35/196 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1221		18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1270..1367		32/206 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142489
Domainoid	1	1.000	305	1.000	Domainoid score	I1372
eggNOG	1	0.900	-	-		E1_28KDT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2649
Isobase	1	0.950	-	0	Normalized mean entropy	S8147
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004207
OrthoInspector	1	1.000	-	-		otm41785
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21564
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4982
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.920