DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and SAP1

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_010966.1	Gene:	SAP1 / 856771	SGDID:	S000000849	Length:	897	Species:	Saccharomyces cerevisiae

Alignment Length:	333	Identity:	113/333 - (33%)
Similarity:	183/333 - (54%)	Gaps:	31/333 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TSKNKKKAK-VLAEEQLKRLAEQEGF-KLRGQEFSDYELMIASHLVVPADITVSWADIAGLDSVI 106
            ||.|:::.: .:.::.|:.:.|.|.. .|:|.: ......|.:.:||..| .|.|.|||||:|..
Yeast   552 TSLNEQREEPEIDKKVLREILEDEIIDSLQGVD-RQAAKQIFAEIVVHGD-EVHWDDIAGLESAK 614

  Fly   107 QELRESVVLPIQHKDLFKHSKLWQAPKGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDK 171
            ..|:|:||.|....|||:  .|.:..:|:||.||||.|||::|:|.|.|:...|.::..:.||.|
Yeast   615 YSLKEAVVYPFLRPDLFR--GLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSK 677

  Fly   172 WYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSR-NMNDHEATAMMKTQFMMLWDGLS----- 230
            :.|||:||..|:|::|.::.|.|||:|||||.:.|| |.|::|::..:|.:|::.|..||
Yeast   678 YLGESEKLVRALFAIAKKLSPSIIFVDEIDSIMGSRNNENENESSRRIKNEFLVQWSSLSSAAAG 742

  Fly   231 -----TNANST--------VIVMGATNRPQDLDKAIVRRMPAQFHIGLP-SETQRKDILKLILQS 281
                 ||.:.|        |:|:.|||.|..:|:|..||...:.:|.|| .:|:.....||:...
Yeast   743 SNKSNTNNSDTNGDEDDTRVLVLAATNLPWSIDEAARRRFVRRQYIPLPEDQTRHVQFKKLLSHQ 807

  Fly   282 EEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSRDPSATALDRNNVR-ITMDDLLG 345
            :....:.|.:.|.|:|.|:||||:..:.::|::..:|.|    .......:|..:| |.:.|...
Yeast   808 KHTLTESDFDELVKITEGYSGSDITSLAKDAAMGPLRDL----GDKLLETEREMIRPIGLVDFKN 868

  Fly   346 SHLKIKES 353
            |.:.||.|
Yeast   869 SLVYIKPS 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	59/152 (39%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	58/148 (39%)
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904
SAP1	NP_010966.1	SpoVK	<557..890	CDD:223540	110/328 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810