Protein Alignment nmd and VPS4

DIOPT Version :10

• Sequence 1: NP_609373.1
• Gene: nmd / 44021
• FlyBaseID: FBgn0005322
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_015499.1
• Gene: VPS4 / 856303
• SGDID: S000006377
• Length: 437
• Species: Saccharomyces cerevisiae
• Alignment Length: 412
• Identity: 116/412 - (28%)
• Similarity: 197/412 - (47%)
• Gaps: 88/412 - (21%)

  Fly     8 GSDLSKG-QIFQVLVRLSVA-----SLITYYS-VKWMM----NQMDPTSKNKKKAK----VLAEE 57
            |..|:|| ::.|..:.|..|     :...||: :.::|    .:.:|.||:..:||    :...|
Yeast     4 GDFLTKGIELVQKAIDLDTATQYEEAYTAYYNGLDYLMLALKYEKNPKSKDLIRAKFTEYLNRAE 68

  Fly    58 QL--------------------------KRLAEQEG--------FKLRGQEFSDYELMIASHLVV 88
            ||                          |:::::||        .||||         ..|..::
Yeast    69 QLKKHLESEEANAAKKSPSAGSGSNGGNKKISQEEGEDNGGEDNKKLRG---------ALSSAIL 124

  Fly    89 PADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAPKGVLLHGPPGCGKTLIAKATA 153
            .....|.|.|:|||:...:.|:|:|:||::...|||.::  :...|:||:||||.||:.:|||.|
Yeast   125 SEKPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNR--KPTSGILLYGPPGTGKSYLAKAVA 187

  Fly   154 KEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSRNMNDHEATAMM 218
            .||...|.::..:.|..||.|||:||...:|::|...:|.||||||:|:...:|...:.||:..:
Yeast   188 TEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDEVDALTGTRGEGESEASRRI 252

  Fly   219 KTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVRRMPAQFHIGLPSETQRKDILKL------ 277
            ||:.::..:|:. |.:..|:|:||||.|..||.||.||...:.:|.||....|..:.::
Yeast   253 KTELLVQMNGVG-NDSQGVLVLGATNIPWQLDSAIRRRFERRIYIPLPDLAARTTMFEINVGDTP 316

  Fly   278 -ILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQL--------ITSRDPSATAL-- 331
             :|..|      |...|..:|.|:||||:..:.::|.:..:|::        :::.|.....|
Yeast   317 CVLTKE------DYRTLGAMTEGYSGSDIAVVVKDALMQPIRKIQSATHFKDVSTEDDETRKLTP 375

  Fly   332 ----DRNNVRITMDDLLGSHLK 349
                |...:.::..|:....||
Yeast   376 CSPGDDGAIEMSWTDIEADELK 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_609373.1	RecA-like_ATAD1	98..263	CDD:410928	66/164 (40%)
		AAA_lid_3	287..323	CDD:465537	10/43 (23%)
VPS4	NP_015499.1	cell_div_CdvC	17..432	CDD:468935	111/399 (28%)
		RecA-like_VPS4	127..296	CDD:410929	68/171 (40%)