DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and PEX1

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	392	Identity:	99/392 - (25%)
Similarity:	178/392 - (45%)	Gaps:	67/392 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YYSVKWMMNQMDPTSKNKKKAKVLAEEQLKRL----------AEQEGFKLRGQE------FSDYE 79
            :.|..|.:...|..::.|......::.|:.:|          .|.|||.....|      |.|.:
Yeast   593 FVSETWSLRAPDKHARAKLLEYFFSKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQ 657

  Fly    80 LMIASHLVVPADI----------------------TVSWADIAGLDSVIQELRESVVLPIQHKDL 122
            |......||..::                      .:.|.||..|.:....|.|::..|.:::.:
Yeast   658 LERDCDNVVTRELFSKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPI 722

  Fly   123 FKHSKLWQAPKGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLA 187
            |.:..| :...|:||:|.|||||||:|.|.|::.|:.||::....:.:|:.|.|::....:|..|
Yeast   723 FVNCPL-RLRSGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERA 786

  Fly   188 SRIEPCIIFIDEIDSFLRSRNMNDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKA 252
            ..::|||:|.||.||....|..:....|..:..|.:...||  ......|.::.||:||..:|.|
Yeast   787 QSVKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDG--AEGLDGVYILAATSRPDLIDSA 849

  Fly   253 IVR--RMPAQFHIGLPSETQRKDILKLILQSEE---------VSQDVDLNRLSKLTNGFSGSDLR 306
            ::|  |:.......:|:|::|.|||:.|:.|::         :.::.||..:::.|.||||:||:
Yeast   850 LLRPGRLDKSVICNIPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQ 914

  Fly   307 EMCRNASVYRMRQLITSRDPSATALDRNNV--------------RITMDDLLGSHLKIKESKMHT 357
            .:|.||.:..:.:.:::.|.|......:|:              |:.:..||...: :.|:|..|
Yeast   915 GLCYNAYLKSVHRWLSAADQSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDV-VHETKTST 978

  Fly   358 SS 359
            |:
Yeast   979 SA 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	44/135 (33%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	43/131 (33%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267
		SpoVK	457..929	CDD:223540	89/338 (26%)
		RecA-like_PEX1_r2	705..862	CDD:410934	49/159 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810