DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and pex6

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_001332652.5	Gene:	pex6 / 792998	ZFINID:	ZDB-GENE-081104-252	Length:	1071	Species:	Danio rerio

Alignment Length:	376	Identity:	104/376 - (27%)
Similarity:	185/376 - (49%)	Gaps:	51/376 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GSDLSKGQIFQVLVRLSVASLITYYSVKWMMNQMDPTSKNKKKAKVLAEEQL-KRLAEQE----- 66
            |.|::.|:|.:......:..|....           |:..|...:.|.|... :.::|||
Zfish   706 GKDVNLGRIAKQTAGFVLGDLCALL-----------TNAGKAAHRRLVETYFPEAVSEQEEEDLC 759

  Fly    67 --GFKLRGQEFS-DYELMIASH---LVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKH 125
              |..:..::|| ..:::..:|   :..|....|||.|:.||..|.:|:.:::.||::|.:|.
Zfish   760 VSGVSVTSEDFSAALDVLQEAHSQAIGAPKIPAVSWQDVGGLQQVKKEILDTIQLPLEHPELL-- 822

  Fly   126 SKLWQAPKGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRI 190
             .|.....|:||:||||.||||:|||.|.|..|.|:::....|.:.:.|:|::....|.|.|...
Zfish   823 -SLGLRRSGLLLYGPPGTGKTLLAKAVATECTMTFLSVKGPELINMYVGQSEENIRQVSSKARSA 886

  Fly   191 EPCIIFIDEIDSFLRSRNMNDHEATAM--MKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAI 253
            .|||||.||:||...:|..:......|  :.:|.:...|||  :::..|.|:||||||..||:::
Zfish   887 APCIIFFDELDSLAPNRGHSGDSGGVMDRVVSQLLAELDGL--HSSGDVFVIGATNRPDLLDQSL 949

  Fly   254 VRRMPAQF----HIGLPSETQRK-DILKLILQSEEVSQDVDLNRL-----SKLTNGFSGSDLREM 308
            :|  |.:|    ::|:..:.:.: .:||.||:..:|...|.|:.:     .:||    |:||..:
Zfish   950 LR--PGRFDKLVYVGINEDRESQLQVLKAILRKFKVDASVCLSDIVESCPPRLT----GADLYSL 1008

  Fly   309 CRNASVYRMRQLITSRDPSATALDRNNVRITMDD----LLGSHLKIKESKM 355
            |.:|.:..:::.| ||.......:.:::.:..:|    |.|....:.|.::
Zfish  1009 CSDAMMCAVKRKI-SRITEGVDSELSSLTLCSEDFSEALSGLQPSVSEQQI 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	53/139 (38%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	51/135 (38%)
pex6	XP_001332652.5	SpoVK	561..1060	CDD:223540	104/376 (28%)
		P-loop_NTPase	562..>620	CDD:304359
		AAA	834..962	CDD:278434	49/131 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900