DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nmd and SPATA5L1

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens

Alignment Length:	309	Identity:	93/309 - (30%)
Similarity:	148/309 - (47%)	Gaps:	39/309 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EGFKLRGQEFSDYELMIASHLVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQ 130
            |.||  ..:.|.:..:|....:.|.|    |.:|.||:.|..:|::|:..|::....|....|.|
Human   439 EAFK--NIQPSSFRSVIGLMDIKPVD----WEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQ 497

  Fly   131 APKGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCII 195
             ||||||:|||||.||.:.:|.|......|:::..|.|...:.|:|:|:.|.:|..|....|.|:
Human   498 -PKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAIL 561

  Fly   196 FIDEIDSFLRSRNMNDHEATAMMKTQFMML--WDGLSTNA-----------------NSTVIVMG 241
            |:|||||.|.:|:.:........:...::|  .||:....                 |.:|:::.
Human   562 FLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIA 626

  Fly   242 ATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDILKLILQSEEVSQDVDLNRLSKLTNGFSGSD 304
            |||||..||.|::|  |:....:|..|....|..|||:..::..:..||.|..|:..|..|||:|
Human   627 ATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGAD 691

  Fly   305 LREMCRNASVYRMRQLITSRDPSATALDRNNVRITMDDLLGSHLKIKES 353
            ||.:|..|::..:::         ..||...|:  .:..|.|...:|.|
Human   692 LRNLCTEAALLALQE---------NGLDATTVK--QEHFLKSLKTVKPS 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	50/154 (32%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	47/150 (31%)
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	93/309 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203
		AAA	237..367	CDD:278434
		AAA	501..651	CDD:278434	46/149 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810