DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and spast

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_012818464.1	Gene:	spast / 549207	XenbaseID:	XB-GENE-947839	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	267	Identity:	109/267 - (40%)
Similarity:	170/267 - (63%)	Gaps:	7/267 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAP-KGVLLHGPPGCGKTLIAK 150
            :|.:..||.:|||||.|...|.|:|.|:||....:||...:   || :|:||.||||.|||::||
Frog   319 IVDSGPTVKFADIAGQDLAKQALQEIVILPSIRPELFTGLR---APARGLLLFGPPGNGKTMLAK 380

  Fly   151 ATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSRNMNDHEAT 215
            |.|.|:...|.|:..|.||.|:.||.:||..|:||:|..::|.||||||:||.|..|...:|:|:
Frog   381 AVAAESNATFFNISAASLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHDAS 445

  Fly   216 AMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVRRMPAQFHIGLPSETQRKDILKLILQ 280
            ..:||:|::.:||:.:..:..|:|||||||||:||.|::||...:.::.||:|..|..:||.:|.
Frog   446 RRLKTEFLIEFDGVQSGGDDRVLVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLLLLKNLLS 510

  Fly   281 SE-EVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSRDPSATALDRNNVRITMDDLL 344
            .: ....:.:|.:||:||.|:||||:..:.::|::..:|:|...:..:..|.:..|::.:  |.|
Frog   511 KQGNPLNEKELTQLSRLTEGYSGSDITALAKDAALGPIRELKPEQVKNMAASEMRNIKYS--DFL 573

  Fly   345 GSHLKIK 351
            .|..|||
Frog   574 SSLKKIK 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	63/134 (47%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	61/129 (47%)
spast	XP_012818464.1	MIT_spastin	110..188	CDD:239142
spast	XP_012818464.1	SpoVK	<278..584	CDD:223540	109/267 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910