Protein Alignment nmd and PEX6

DIOPT Version :10

• Sequence 1: NP_609373.1
• Gene: nmd / 44021
• FlyBaseID: FBgn0005322
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_000278.3
• Gene: PEX6 / 5190
• HGNCID: 8859
• Length: 980
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 105/337 - (31%)
• Similarity: 159/337 - (47%)
• Gaps: 55/337 - (16%)

  Fly    46 KNKKKAKVLAEEQLKRLAEQEGFKLRGQEFSD-YELMIASH---LVVPADITVSWADIAGLDSVI 106
            ||...|..|.||....|. ..||.|..::|.. .|.:..:|   :..|...:|||.|:.||..|.
Human   651 KNSGLAGGLTEEDEGELC-AAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVK 714

  Fly   107 QELRESVVLPIQHKDLFKHSKLWQAPKGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDK 171
            :|:.|::.||::|.:|.   .|.....|:|||||||.||||:|||.|.|..:.|:::....|.:.
Human   715 KEILETIQLPLEHPELL---SLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINM 776

  Fly   172 WYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSRNMNDHEATAM--MKTQFMMLWDGLSTNAN 234
            :.|:|::....||:.|....|||||.||:||...||..:......|  :.:|.:...|||  ::.
Human   777 YVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGL--HST 839

  Fly   235 STVIVMGATNRPQDLDKAIVRRMPAQFHIGLPSETQRKDILKLILQSEEVSQDVDLNRLSKLTNG 299
            ..|.|:||||||..||.|::|  |.:|.             ||:.......:...|..||.:|..
Human   840 QDVFVIGATNRPDLLDPALLR--PGRFD-------------KLVFVGANEDRASQLRVLSAITRK 889

  Fly   300 F-------------------SGSDLREMCRNASV----YRMRQLITSRDPSATALDRNNVRITMD 341
            |                   :|:||..:|.:|..    .|:..|....:|.::||     .:||:
Human   890 FKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSAL-----MLTME 949

  Fly   342 DLLGSHLKIKES 353
            |||.:..:::.|
Human   950 DLLQAAARLQPS 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_609373.1	RecA-like_ATAD1	98..263	CDD:410928	65/166 (39%)
		AAA_lid_3	287..323	CDD:465537	12/58 (21%)
PEX6	NP_000278.3	CDC48	<466..977	CDD:273521	105/337 (31%)