DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and Iqca1l

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001019488.2	Gene:	Iqca1l / 499971	RGDID:	1564789	Length:	822	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	72/372 - (19%)
Similarity:	145/372 - (38%)	Gaps:	88/372 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TSKNKKKAKVLAEEQLKRLAEQEGFKLRGQEFSDYELMIASHLVVPADITVSWADIAG----LDS 104
            :.|.||:..:..:..:..|.|              ||::..  ::...:.|:..|..|    |.|
  Rat   474 SGKKKKEKDLTPDRSVDSLFE--------------ELVVIG--LIKKSLLVTLNDYIGDCLYLGS 522

  Fly   105 VIQ-----------ELRESV----VLPIQHKDLFKHSKLWQAP--KGVLLHGPPGCGKTLIAKAT 152
            .:.           ::|:::    ||.:...|:  |:   .||  :.:||.||.|.||.::.:|.
  Rat   523 TLTLANKIPMPSLFDIRQNIALYGVLRLGSHDI--HT---MAPLVRSILLVGPSGMGKKMLVQAV 582

  Fly   153 AKEAGMRFINLDVAILTDKWYGE--SQKLTSAVFSLASRIEPCIIFIDEID-SFLR-----SRNM 209
            ..|.|....:|....:..|:.|:  ||.|...||.:|...:|.:|:|...: :|.:     .|.|
  Rat   583 CTETGANLFDLSPGNVMGKYPGKNGSQLLMHIVFKVARVFQPSVIWIGNTEKTFYKKIPKEERRM 647

  Fly   210 NDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLD-KAIVRRMPAQFHIGLPSETQRKD 273
            :.......:......|..|      ..|:::|.|.|||..: |.:.|.......|..|....|..
  Rat   648 DPKRIKKDLMRATRQLGPG------DRVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASRYV 706

  Fly   274 ILKLILQSEEV----SQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSR---------- 324
            :.|.:::::.:    :|.:|::.|:::::|::...:.:..::....|....:|.:
  Rat   707 LWKRMIENQGIGVQQTQSLDISALARVSDGYTPGHILQSIQSVLTERRLLQLTKKPLVASEFVVH 771

  Fly   325 ----DP-------------SATALDRNNVRITMDDLLGSHLKIKESK 354
                ||             ..|.|.:.|::.|.|.......::.:.|
  Rat   772 LAKLDPVYREEEESLKEWFYKTPLGKKNIKFTKDQQEAEEARLAKEK 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	37/144 (26%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	36/138 (26%)
Iqca1l	NP_001019488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..378
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..484		3/9 (33%)
		SpoVK	<563..738	CDD:223540	43/180 (24%)
		AAA	565..698	CDD:278434	36/138 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810