Protein Alignment nmd and NSF

DIOPT Version :10

• Sequence 1: NP_609373.1
• Gene: nmd / 44021
• FlyBaseID: FBgn0005322
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 111/447 - (24%)
• Similarity: 183/447 - (40%)
• Gaps: 119/447 - (26%)

  Fly    11 LSKGQIFQVLVRLSVASLITYYSVKWMMNQM--------------DPTSKNKKKAKVLAE--EQL 59
            ||.||..:|       ||.|:...|..:..|              :|...:|..|:.:.:  .|.
Human    72 LSIGQEIEV-------SLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQA 129

  Fly    60 KRLAEQEGF----KLRGQEFSDYELMIASHL-----------------VVPADITVSWADIAGLD 103
            ..:.:|..|    ||.|....|.|.|..|.|                 |..:.:....|:.:.|:
Human   130 FSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLN 194

  Fly   104 SV----IQELRESVVLP-------------IQHKDLFKH---SKLW----------QAPKGVLLH 138
            .:    .:|.|:|::.|             .:..|:|:.   |:::          :..||:||:
Human   195 LIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLY 259

  Fly   139 GPPGCGKTLIAKATAKEAGMR---FINLDVAILTDKWYGESQKLTSAVFS--------LASRIEP 192
            |||||||||:|:...|....|   .:| ...|| :|:.|||:.....:|:        |.:....
Human   260 GPPGCGKTLLARQIGKMLNAREPKVVN-GPEIL-NKYVGESEANIRKLFADAEEEQRRLGANSGL 322

  Fly   193 CIIFIDEIDSFLRSR-----NMNDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKA 252
            .||..||||:..:.|     :...|:...   .|.:...||:....|  ::|:|.||||..:|:|
Human   323 HIIIFDEIDAICKQRGSMAGSTGVHDTVV---NQLLSKIDGVEQLNN--ILVIGMTNRPDLIDEA 382

  Fly   253 IVR--RMPAQFHIGLPSETQRKDILKL----ILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRN 311
            ::|  |:..:..||||.|..|..||.:    :...:.:|.|||:..|:..|..|||::|..:.|.
Human   383 LLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRA 447

  Fly   312 ASVYRMRQLITSRDPSATALDR-NNVRITMDDLLGSHLKIKESKMHTSSLFLENRIE 367
            |....|.:.|.:.......::: .::::|..|.|.|               |||.|:
Human   448 AQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLAS---------------LENDIK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_609373.1	RecA-like_ATAD1	98..263	CDD:410928	55/212 (26%)
		AAA_lid_3	287..323	CDD:465537	13/35 (37%)
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	6/17 (35%)
		CDC48_2	111..183	CDD:215011	15/71 (21%)
		CDC48	159..>606	CDD:273521	88/353 (25%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	50/182 (27%)