DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and vcp

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001005677.1	Gene:	vcp / 448177	XenbaseID:	XB-GENE-969573	Length:	805	Species:	Xenopus tropicalis

Alignment Length:	322	Identity:	113/322 - (35%)
Similarity:	168/322 - (52%)	Gaps:	57/322 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITYYSVKWMMNQMDPTSKNKKKAKVLAEEQLKRLAEQEGFKLRGQEFSDYELMIASHLVVPADIT 93
            :|....:|.::|.:|::        |.|..::                           ||   .
Frog   447 VTMDDFRWALSQSNPSA--------LRETVVE---------------------------VP---Q 473

  Fly    94 VSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAP-KGVLLHGPPGCGKTLIAKATAKEAG 157
            |:|.||.||:.|.:||:|.|..|::|.|  |..|....| ||||.:|||||||||:|||.|.|..
Frog   474 VTWEDIGGLEDVKRELQELVQYPVEHPD--KFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQ 536

  Fly   158 MRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSR--NMNDHEATA-MMK 219
            ..||::....|...|:|||:.....:|..|.:..||::|.||:||..::|  |:.|....| .:.
Frog   537 ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVI 601

  Fly   220 TQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDILKLILQSE 282
            .|.:...||:||..|  |.::||||||..:|.||:|  |:....:|.||.|..|..|||..|:..
Frog   602 NQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRIAILKANLRKS 664

  Fly   283 EVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSR---------DPSATALDRNN 335
            .|::||||:.|:|:||||||:||.|:|:.|....:|:.|.:.         :|||..::.::
Frog   665 PVAKDVDLDFLAKMTNGFSGADLTEICQRACKLAIRESIENEIRRERERQTNPSAMEVEEDD 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	58/139 (42%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	55/134 (41%)
vcp	NP_001005677.1	CDC48	25..764	CDD:273521	113/322 (35%)
vcp	NP_001005677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..805
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910