DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and nsfa

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_021325418.1	Gene:	nsfa / 368483	ZFINID:	ZDB-GENE-030616-37	Length:	747	Species:	Danio rerio

Alignment Length:	336	Identity:	90/336 - (26%)
Similarity:	150/336 - (44%)	Gaps:	46/336 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPTSKNKKKAKV---LAEEQ-LKRLAEQEGFKLRGQEFSDYELMIASHLVVPADITVSWADIAGL 102
            :|.|..|:|.:|   :...| :...:|.....|.|:.    :...|...::..|.......|.||
Zfish   163 EPASGKKQKIEVGLLVGNSQVIFEKSESSSLTLVGKA----KTKEARQTIINPDWNFEKMGIGGL 223

  Fly   103 DSVIQEL-RESVVLPIQHKDLF-----KHSKLWQAPKGVLLHGPPGCGKTLIAKATAKEAGMR-- 159
            |....:: |.:....:...|:.     ||      .||:||.|||||||||:|:...|....|
Zfish   224 DKEFSDIFRRAFASRVFPPDIVEQMGCKH------VKGILLFGPPGCGKTLMARQIGKMLNAREP 282

  Fly   160 -FINLDVAILTDKWYGESQKLTSAVFS--------LASRIEPCIIFIDEIDSFLRSRNMNDHEAT 215
             .:| ...|| :|:.|||:.....:|:        |.:.....||..||:|:..:.|. ....:|
Zfish   283 KIVN-GPEIL-NKYVGESEANIRKLFADAEEEQKRLGANSGLHIIIFDELDAICKQRG-TGASST 344

  Fly   216 AMMKT---QFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDIL 275
            .:..|   |.:...||:....|  ::|:|.||||..:|:|::|  |...:..||||.|..|..||
Zfish   345 GVHDTVVNQLLSKIDGVEQLNN--ILVIGMTNRPDLIDEALMRPGRFEVKMEIGLPDEKGRVQIL 407

  Fly   276 KL----ILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSRDPSATALDR-NN 335
            .:    :.:.:.::.|||:..|:..|..:||::|..:.|.|....|.:.|.:.......::| ..
Zfish   408 NIHTAKMREFKLLASDVDVKELAAETKNYSGAELEGLVRAAQSTAMNRHIKATSTVEVDMERAEK 472

  Fly   336 VRITMDDLLGS 346
            :::|..|.:.|
Zfish   473 LQVTRTDFMAS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	49/149 (33%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	46/145 (32%)
nsfa	XP_021325418.1	CDC48_N	6..83	CDD:215012
		CDC48_2	111..183	CDD:215011	5/19 (26%)
		TIP49	160..>606	CDD:332389	90/336 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900