DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and Spast

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_008762708.1	Gene:	Spast / 362700	RGDID:	1308494	Length:	614	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	115/317 - (36%)
Similarity:	188/317 - (59%)	Gaps:	22/317 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PTSKNKKKAKVLAEEQLKRLAEQEGFKLRGQEFSDYELMIASHL---VVPADITVSWADIAGLDS 104
            |...||......|..:.|.|          :.|.:.:..:|:.:   :|.....|.:.||||.:.
  Rat   293 PNRTNKPSTPTTAVRKKKDL----------KNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQEL 347

  Fly   105 VIQELRESVVLPIQHKDLFKHSKLWQAP-KGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAIL 168
            ..|.|:|.|:||....:||...:   || :|:||.||||.|||::|||.|.|:...|.|:..|.|
  Rat   348 AKQALQEIVILPSLRPELFTGLR---APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASL 409

  Fly   169 TDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSRNMNDHEATAMMKTQFMMLWDGLSTNA 233
            |.|:.||.:||..|:|::|..::|.||||||:||.|..|...:|:|:..:||:|::.:||:.:..
  Rat   410 TSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAG 474

  Fly   234 NSTVIVMGATNRPQDLDKAIVRRMPAQFHIGLPSETQRKDILKLIL--QSEEVSQDVDLNRLSKL 296
            :..|:|||||||||:||:|::||...:.::.||:|..|..:||.:|  |...::|. :|.:|:::
  Rat   475 DDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARM 538

  Fly   297 TNGFSGSDLREMCRNASVYRMRQLITSRDPSATALDRNNVRITMDDLLGSHLKIKES 353
            |:|:|||||..:.::|::..:|:|...:..:.:|.:..|:|::  |...|..|||.|
  Rat   539 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLS--DFTESLKKIKRS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	62/134 (46%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	60/129 (47%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142
		P-loop_NTPase	339..>395	CDD:304359	27/58 (47%)
		AAA	372..508	CDD:214640	63/135 (47%)
		AAA	376..506	CDD:278434	60/129 (47%)
		Vps4_C	<578..610	CDD:286426	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810