DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nmd and vcp

DIOPT Version :9

Sequence 1:NP_001285801.1 Gene:nmd / 44021 FlyBaseID:FBgn0005322 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_958889.1 Gene:vcp / 327197 ZFINID:ZDB-GENE-030131-5408 Length:806 Species:Danio rerio


Alignment Length:322 Identity:112/322 - (34%)
Similarity:168/322 - (52%) Gaps:57/322 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 ITYYSVKWMMNQMDPTSKNKKKAKVLAEEQLKRLAEQEGFKLRGQEFSDYELMIASHLVVPADIT 93
            :|....:|.::|.:|::        |.|..::                           ||   .
Zfish   447 VTMDDFRWALSQSNPSA--------LRETVVE---------------------------VP---N 473

  Fly    94 VSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAP-KGVLLHGPPGCGKTLIAKATAKEAG 157
            ::|.||.|||.|.:||:|.|..|::|.|  |..|....| ||||.:|||||||||:|||.|.|..
Zfish   474 ITWEDIGGLDDVKRELQELVQYPVEHPD--KFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQ 536

  Fly   158 MRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSR--NMNDHEATA-MMK 219
            ..||::....|...|:|||:.....:|..|.:..||::|.||:||..::|  |:.|....| .:.
Zfish   537 ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNVGDGGGAADRVI 601

  Fly   220 TQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDILKLILQSE 282
            .|.:...||:|:..|  |.::||||||..:|.||:|  |:....:|.||.|..|..|||..|:..
Zfish   602 NQILTEMDGMSSKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRIAILKANLRKS 664

  Fly   283 EVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSR---------DPSATALDRNN 335
            .:|:||||:.|:|:||||||:||.|:|:.|....:|:.|.:.         :|||..::.::
Zfish   665 PISKDVDLDFLAKMTNGFSGADLTEICQRACKLAIRESIENEIRRERERQTNPSAMEVEEDD 726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nmdNP_001285801.1 AAA 132..266 CDD:214640 57/139 (41%)
AAA 135..265 CDD:278434 54/134 (40%)
vcpNP_958889.1 CDC48 25..764 CDD:273521 112/322 (35%)
CDC48_N 25..107 CDD:280513
CDC48_2 131..191 CDD:215011
AAA 241..370 CDD:278434
P-loop_NTPase 452..>534 CDD:304359 41/121 (34%)
AAA 514..647 CDD:278434 54/134 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727 3/19 (16%)
Vps4_C <718..760 CDD:286426 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.