DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and SPCC24B10.10c

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_588013.1	Gene:	SPCC24B10.10c / 2539116	PomBaseID:	SPCC24B10.10c	Length:	355	Species:	Schizosaccharomyces pombe

Alignment Length:	318	Identity:	138/318 - (43%)
Similarity:	208/318 - (65%)	Gaps:	19/318 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SKGQIFQVLVRLSVASLITYYSVKWMMNQMDP--------TSKNKKKAKVLAEEQLKRLAEQEGF 68
            :|..|.:::| .::|...::|:...:::.:||        .||::|:....|.||:|
pombe     5 TKRAIKEIVV-YALAFGCSWYAAHKLLSTLDPYRQKRQDTVSKSRKRLDEWAGEQVK-------- 60

  Fly    69 KLRGQEFSDYELMIASHLVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLF-KHSKLWQAP 132
            :|...|.::||.::||.||:|::|.||:.||.|:|..:.:|.:.|:.|:::.::| .|..|...|
pombe    61 ELETLELNEYEQIVASQLVLPSEIDVSFDDIGGMDEHVNQLLQDVLFPLKYPEVFDTHGGLLSCP 125

  Fly   133 KGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFI 197
            ||:||:||||||||::|||.||::...|||:.|.:|||||:|||.||..|:|:||.::||.||||
pombe   126 KGLLLYGPPGCGKTMLAKALAKQSQATFINVSVGLLTDKWFGESNKLVDALFTLARKLEPTIIFI 190

  Fly   198 DEIDSFLRSRNMNDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVRRMPAQFH 262
            ||||:|||.|...||||.|.:|.:||.:|||| .:..|.|:|:||||||.|:|:||.||||..|.
pombe   191 DEIDTFLRQRQRTDHEAMAQIKAEFMSMWDGL-LSGQSRVLVLGATNRPADIDEAIRRRMPKVFS 254

  Fly   263 IGLPSETQRKDILKLILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQL 320
            |.||:..||:.||:|.|:...:..:.|.|.:...|.|.|||.::|:||:|.....|:|
pombe   255 IPLPNAEQRRKILELYLKKVPLEANFDWNGVVNATAGLSGSYIKEVCRSALSVPRREL 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	81/133 (61%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	78/129 (60%)
SPCC24B10.10c	NP_588013.1	AAA	125..249	CDD:214640	76/124 (61%)
SPCC24B10.10c	NP_588013.1	AAA	128..257	CDD:278434	78/129 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	170	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5960
Inparanoid	1	1.050	262	1.000	Inparanoid score	I741
OMA	1	1.010	-	-		QHG53576
OrthoFinder	1	1.000	-	-		FOG0002611
OrthoInspector	1	1.000	-	-		otm47007
orthoMCL	1	0.900	-	-		OOG6_103164
Panther	1	1.100	-	-	LDO	PTHR45644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1910
SonicParanoid	1	1.000	-	-		X1716
TreeFam	1	0.960	-	-
	14	13.860