DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and Nsf

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_032766.2	Gene:	Nsf / 18195	MGIID:	104560	Length:	744	Species:	Mus musculus

Alignment Length:	352	Identity:	93/352 - (26%)
Similarity:	157/352 - (44%)	Gaps:	76/352 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LRGQEFSDYELMIASHLVV-PADITVSWADIAGLDSV----IQELRESVVLP------------- 116
            |:|:..|.....|...||| .:.:....|:.:.|:.:    .:|.|:|::.|
Mouse   160 LKGEPASGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLD 224

  Fly   117 IQHKDLFKH---SKLW----------QAPKGVLLHGPPGCGKTLIAKATAKEAGMR---FINLDV 165
            .:..|:|:.   |:::          :..||:||:|||||||||:|:...|....|   .:| ..
Mouse   225 KEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVN-GP 288

  Fly   166 AILTDKWYGESQKLTSAVFS--------LASRIEPCIIFIDEIDSFLRSR-----NMNDHEATAM 217
            .|| :|:.|||:.....:|:        |.:.....||..||||:..:.|     :...|:...
Mouse   289 EIL-NKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVV- 351

  Fly   218 MKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDILKL--- 277
              .|.:...||:....|  ::|:|.||||..:|:|::|  |:..:..||||.|..|..||.:
Mouse   352 --NQLLSKIDGVEQLNN--ILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTA 412

  Fly   278 -ILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSRDPSATALDR-NNVRITM 340
             :...:.:|.|||:..|:..|..|||::|..:.|.|....|.:.|.:.......::: .::::|.
Mouse   413 RMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTR 477

  Fly   341 DDLLGSHLKIKESKMHTSSLFLENRIE 367
            .|.|.|               |||.|:
Mouse   478 GDFLAS---------------LENDIK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	49/151 (32%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	46/147 (31%)
Nsf	NP_032766.2	CDC48_N	6..83	CDD:215012
		CDC48_2	111..183	CDD:215011	7/22 (32%)
		AAA	254..399	CDD:214640	50/151 (33%)
		AAA	256..397	CDD:278434	46/147 (31%)
		AAA	538..670	CDD:214640
		AAA	539..668	CDD:278434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900