DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and mspn-1

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_501860.1	Gene:	mspn-1 / 177896	WormBaseID:	WBGene00010557	Length:	342	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	142/312 - (45%)
Similarity:	214/312 - (68%)	Gaps:	9/312 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KGQIFQVLVRLSVASLITYYSVKWMMNQMDPT-SKNKKKAKVLAEEQLKRLAEQEGFKLRGQEFS 76
            :.::..|.:|:..|:.:::.||::::..:||. |.|::..|.:|:     |..:.|.. |..|.|
Worm     4 RNELIGVAIRVVAAAAVSFLSVRYLVKYLDPNYSVNEESKKKVAQ-----LFHELGID-RQIELS 62

  Fly    77 DYELMIASHLVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAPKGVLLHGPP 141
            ::|:.||:..|...|:...|.:|.|.:.::.||::.::||::.... ..|.|...|:|:||:|||
Worm    63 EHEIRIATQFVGGEDVGADWDEIGGCEELVAELKDRIILPLRFASQ-SGSHLLSPPRGILLYGPP 126

  Fly   142 GCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRS 206
            ||||||:|||.|:.||.|||||.|:.||||||||||||.:||||:|.:.:|.||||||||||||.
Worm   127 GCGKTLLAKAVARAAGCRFINLQVSNLTDKWYGESQKLAAAVFSVAQKFQPTIIFIDEIDSFLRD 191

  Fly   207 RNMNDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVRRMPAQFHIGLPSETQR 271
            |..:|||:|||||.|||.||||.|::.:. :|||||||||:|:|.||:|||.|:|.:.:|:..||
Worm   192 RQSHDHESTAMMKAQFMTLWDGFSSSGDQ-IIVMGATNRPRDVDAAILRRMTARFQVPVPNAKQR 255

  Fly   272 KDILKLILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITS 323
            ..||.:||::|:::..|:|..:::...|.|||||:|:||.|.:.|.:..:.|
Worm   256 SQILNVILRNEKINNTVNLGEIAQAAEGLSGSDLKEVCRLALLARAKATVAS 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	90/133 (68%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	88/129 (68%)
mspn-1	NP_501860.1	AAA	116..244	CDD:214640	88/128 (69%)
mspn-1	NP_501860.1	AAA	120..249	CDD:278434	88/129 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167122
Domainoid	1	1.000	185	1.000	Domainoid score	I2010
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I1741
Isobase	1	0.950	-	0	Normalized mean entropy	S651
OMA	1	1.010	-	-		QHG53576
OrthoDB	1	1.010	-	-		D1430018at2759
OrthoFinder	1	1.000	-	-		FOG0002611
OrthoInspector	1	1.000	-	-		otm14701
orthoMCL	1	0.900	-	-		OOG6_103164
Panther	1	1.100	-	-	LDO	PTHR45644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1910
SonicParanoid	1	1.000	-	-		X1716
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.890