DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and mac-1

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_496814.1	Gene:	mac-1 / 174974	WormBaseID:	WBGene00003119	Length:	813	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	102/346 - (29%)
Similarity:	168/346 - (48%)	Gaps:	47/346 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GGSDLSKGQIFQVLVRLSVASLITYYSVKWMMNQMDPTSKNKKKAKV-LAEEQLKR-------LA 63
            |..:|:..||.:.|.|:          :.|:....||::.::....: ::.|..:|       .|
Worm   465 GHKNLTVEQIKEELDRV----------LAWLQGDDDPSALSELNGGLQISFEDFERALSTIQPAA 519

  Fly    64 EQEGFKLRGQEFSDYELMIASHLVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKL 128
            ::|||                 ..||   .|||.||..|..|.::|..|::.||:..|.|....:
Worm   520 KREGF-----------------ATVP---DVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGI 564

  Fly   129 WQAPKGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPC 193
            ...|:|:||.|||||||||:|||.|.|.||.||::....|.:.:.|||::....||..|...:||
Worm   565 DCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPC 629

  Fly   194 IIFIDEIDSFLRSRNMNDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVR--R 256
            :||.||||:.:..|:..:....|.:..|.:...||:  .....|.::||||||..:|.||:|  |
Worm   630 VIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGV--EGRQKVFLIGATNRPDIVDAAILRPGR 692

  Fly   257 MPAQFHIGLPSETQRKDILKLILQS---EEVSQDVDLNRLSKLTN--GFSGSDLREMCRNASVYR 316
            :.....:..||...|.|||:...::   ..:.:|:|.:.:::|..  ||:|:||..:...:|:..
Worm   693 LDKILFVDFPSVEDRVDILRKSTKNGTRPMLGEDIDFHEIAQLPELAGFTGADLAALIHESSLLA 757

  Fly   317 MRQLITSRDPSATALDRNNVR 337
            ::..:...|.|...:...:.|
Worm   758 LQARVLENDESVKGVGMRHFR 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	54/135 (40%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	52/131 (40%)
mac-1	NP_496814.1	Nucleolin_bd	5..65	CDD:318849
mac-1	NP_496814.1	TIP49	<191..804	CDD:332389	102/346 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810