DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nmd and cdc-48.1

DIOPT Version :9

Sequence 1:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_496273.1	Gene:	cdc-48.1 / 174624	WormBaseID:	WBGene00007352	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	329	Identity:	115/329 - (34%)
Similarity:	169/329 - (51%)	Gaps:	41/329 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GLGGSDL----SKGQIFQVLVRLSVASLITYYSVKWMMNQMDPTSKNKKKAKVLAEEQLKRLA-E 64
            |..|:||    |:..:.|:..::.:..|..        :|:|             .|.|..|| .
Worm   411 GFVGADLASLCSEAALQQIREKMELIDLED--------DQID-------------AEVLNSLAVT 454

  Fly    65 QEGFKLRGQEFSDYELMIASHLVVPADITVSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLW 129
            .|.|:....:.|...|..|   ||....| :|:||.||.:|.:||:|.|..|::|.:  |:.|..
Worm   455 MENFRFAQGKSSPSALREA---VVETPNT-TWSDIGGLQNVKRELQELVQYPVEHPE--KYLKFG 513

  Fly   130 QAP-KGVLLHGPPGCGKTLIAKATAKEAGMRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPC 193
            ..| :|||.:|||||||||:|||.|.|....||::....|...|:|||:.....||..|....||
Worm   514 MQPSRGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPC 578

  Fly   194 IIFIDEIDSFLRSR----NMNDHEATAMMKTQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIV 254
            ::|.||:||..::|    ..:...|:..:..|.:...||:  ||...|.::||||||..:|.|::
Worm   579 VLFFDELDSIAKARGGGAGGDGGGASDRVINQVLTEMDGM--NAKKNVFIIGATNRPDIIDPAVL 641

  Fly   255 R--RMPAQFHIGLPSETQRKDILKLILQSEEVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRM 317
            |  |:....:|.||.|..|..|||..|:...:|:|:||..|:|.|.||||:||.|:|:.|....:
Worm   642 RPGRLDQLIYIPLPDEASRHQILKASLRKTPLSKDLDLTFLAKNTVGFSGADLTEICQRACKLAI 706

  Fly   318 RQLI 321
            |:.|
Worm   707 RESI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nmd	NP_001285801.1	AAA	132..266	CDD:214640	54/140 (39%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	52/135 (39%)
cdc-48.1	NP_496273.1	CDC48_N	31..112	CDD:280513
		CDC48	52..775	CDD:273521	115/329 (35%)
		CDC48_2	137..197	CDD:215011
		AAA	247..376	CDD:278434
		AAA	520..654	CDD:278434	52/135 (39%)
		Vps4_C	<727..771	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810