DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cas and Casz1

DIOPT Version :9

Sequence 1:	NP_524677.1	Gene:	cas / 44018	FlyBaseID:	FBgn0004878	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_006539220.1	Gene:	Casz1 / 69743	MGIID:	1196251	Length:	1886	Species:	Mus musculus

Alignment Length:	806	Identity:	234/806 - (29%)
Similarity:	342/806 - (42%)	Gaps:	172/806 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QQLAGYTYTQNEDISSSTSVQ------QQQQQQQEQLQQPQPDLRKTRTHKRISSQNTNCSSSRS 92
            :|.:|.| :...|.::||..:      ...|..:::|.            |:||.:..:..|:..
Mouse   188 RQASGET-SSLRDYAASTMTEFLGMFGYDDQNTRDELA------------KKISFEKPHAGSTPE 239

  Fly    93 CSPNSNLIAFQP-----------QQYPGATAATPSTP-NSHPSNLVNQMLLQSLPPLTQLMLQQQ 145
            .:.:|.|.:.:.           ::|.....|....| .:|.|...::...:.:.||..|.| ..
Mouse   240 VAASSMLPSSEDTLSKRARFSKYEEYIRKLKAGEQLPWPAHGSKAEDRAGKEVVGPLPSLRL-PS 303

  Fly   146 QQQHLLTTSNLLLTPTHTPSSL-------GKQDPLQHPLLLGQFAGSEQMATNNFLQSSTVTSTP 203
            ...||.|.:.:|..|:|:...:       .|.|...|.|..|:         |...|:.:....|
Mouse   304 NTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIHKLKTGE---------NLRPQNGSTYKKP 359

  Fly   204 IERE----------KAATPAPSAGATAGNLSAAQVKFEQESADDDEDDDKPLSSLTSCSSSGHTN 258
            .:.:          |....:|..|   |.::....|..:.|..|.....||          |.|.
Mouse   360 SKYDLENVKYLHLFKPGEGSPDMG---GAIAFKTGKVGRPSKYDVRGIQKP----------GPTK 411

  Fly   259 ASSEKLLLSGVHPLESTTDSLDSPSMY-TPVKQPADSSYGLITPVDSDLTPNTP---LQPTQTIS 319
                      :.|         :||:. ||           :|.|.|  .|:||   .:|..::|
Mouse   412 ----------IPP---------APSLVPTP-----------LTNVPS--APSTPGPGPEPPASLS 444

  Fly   320 LLTPPSSEQSKSLVSL--SAASGLDALLQN----------EEV---LKNLRKVSSYLECENSLCR 369
            ..||   |..||..|.  |..:|..:.::|          |:|   .|.:.:.|....|.:..|.
Mouse   445 FNTP---EYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCA 506

  Fly   370 QENLREHFHCHEEPCQGKILSKKDDIIRHLKWHKKRKESLKLGFARFSSSDDCAPAYGEGCAYNW 434
            .: .|||:||.:..|..:..:.|.|:|||...||||..||:.||.|||..|||: .|..||..|.
Mouse   507 YQ-YREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCS-VYYHGCHLNG 569

  Fly   435 KQTHYHCVYEHCPKVYVSTSDVQMHANFHRKDSEIVNEGFRRFRAHETCRIEDCPFFGKKISHYH 499
            |.|||||:...|.|||.|||||..|.|||:|:::::|:||:||||.|.|...||.|:|:|.:|:|
Mouse   570 KSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFH 634

  Fly   500 CCREGCTHTFKNKADMDKHKTYHLKDHQLKMDGFKKILKTEVCPFDACKFSTVCNHIHCVREGCD 564
            |.|.|||.|||||.|::|||:||:||.....|||||..|.|.|.::.|.:|...||.||:|.||.
Mouse   635 CRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCMYSKATNHFHCIRAGCG 699

  Fly   565 YILHSSSQMISHKRKHDRQDGEQAYQQFKIKQD----VEESSLDAMPQQQQQQQQQQPTSLSQSQ 625
            :...|:|||.||||||:|:         .|:..    :..|.|.|...:.::.........|...
Mouse   700 FTFTSTSQMTSHKRKHERR---------HIRSSGALGLPASLLGAKDTEHEESSNDDLVDFSALS 755

  Fly   626 SSSSVCGGSNTSTPLS-SLSAEHFLARKRGRPPKKIQLPADAQQSEAKRLKVEDESSNPAMLLPQ 689
            |.:|....|.||...| ||:|                 .|.|..:||.....:..:|..|.||||
Mouse   756 SKNSSLSASPTSQQSSASLAA-----------------AAAATTAEAIPSATKPPNSKMAGLLPQ 803

  Fly   690 SQPAAAVHPLTSGLFPGLLPAAAAPGVDPTAPNFQL--THLMALFQLQNPLFYQNLYPGMTQNSS 752
            .         .||..| |..|.:..|:..|.|.|.|  ....|...:.:|....::..|.|  :|
Mouse   804 G---------LSGSIP-LALALSNSGLPTTTPYFPLLPNRGSASLPVGSPGLLGSMSSGAT--TS 856

  Fly   753 MLGNLAALSAASAAAAAAAAANGAGV 778
            ...::.||.|:.|..:|..||....|
Mouse   857 ATPDMPALMASRAGDSAPTAATSLSV 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cas	NP_524677.1	None
Casz1	XP_006539220.1	PHA03247	<823..1182	CDD:223021	17/62 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4377
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006505
OrthoInspector	1	1.000	-	-		oto92811
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12451
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8092
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.990