Protein Alignment cas and CASZ1

DIOPT Version :9

• Sequence 1: NP_524677.1
• Gene: cas / 44018
• FlyBaseID: FBgn0004878
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_016857028.1
• Gene: CASZ1 / 54897
• HGNCID: 26002
• Length: 1883
• Species: Homo sapiens
• Alignment Length: 774
• Identity: 229/774 - (29%)
• Similarity: 324/774 - (41%)
• Gaps: 183/774 - (23%)

  Fly    83 QNTNCSSSRSCSPNSNLIAFQPQQYPGATAATPSTPNSHPSNLVNQMLLQSLPPLTQLMLQQQQQ 147
            |||....:|.       |:|: :.:.|:|          |....:.||..|...|::.....:.:
Human   218 QNTRDELARK-------ISFE-KLHAGST----------PEAATSSMLPTSEDTLSKRARFSKYE 264

  Fly   148 QHL--LTTSNLLLTP---THTPSSLGKQDPLQHPLLLGQFAGSEQMATNNFLQSSTVTSTPIERE 207
            :::  |.....|..|   |.|...:||:       ::|...|..       |.|||   ..:|.:
Human   265 EYIRKLKAGEQLSWPAPSTKTEERVGKE-------VVGTLPGLR-------LPSST---AHLETK 312

  Fly   208 KAATPAPS-AGATAGNLSAAQVKFEQESADDDEDDDKPLSSLTSCSS----SGHTNASSEKLLLS 267
            ....|.|| :.....||.|...|:           |..:..|.:..:    :|.|.....|..|.
Human   313 ATILPLPSHSSVQMQNLVARASKY-----------DFFIQKLKTGENLRPQNGSTYKKPSKYDLE 366

  Fly   268 GV------HPLESTTD----------SLDSPSMYT--------PVKQPADSSYGLITPVDSDLTP 308
            .|      .|.|.:.|          .:..||.|.        |.|.|...|   :.|......|
Human   367 NVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPTPS---LAPAPLASVP 428

  Fly   309 NTPL------QPTQTISLLTPPSSEQSKSLVSL--SAASGLDALLQN----------EEV---LK 352
            :.|.      :|..::|..||   |..||..|.  |..:|..:.::|          |:|   .|
Human   429 SAPSAPGPGPEPPASLSFNTP---EYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQK 490

  Fly   353 NLRKVSSYLECENSLCRQENLREHFHCHEEPCQGKILSKKDDIIRHLKWHKKRKESLKLGFARFS 417
            .:.:.|....|.:..|..: .|||:||.:..|..:..:.|.|:|||...||||..||:.||.|||
Human   491 YIARFSGSQHCGHIHCAYQ-YREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFS 554

  Fly   418 SSDDCAPAYGEGCAYNWKQTHYHCVYEHCPKVYVSTSDVQMHANFHRKDSEIVNEGFRRFRAHET 482
            ..|||: .|..||..|.|.|||||:...|.|||.|||||..|.|||:|:::::|:||:||||.|.
Human   555 PLDDCS-VYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATED 618

  Fly   483 CRIEDCPFFGKKISHYHCCREGCTHTFKNKADMDKHKTYHLKDHQLKMDGFKKILKTEVCPFDAC 547
            |...||.|:|:|.:|:||.|.|||.|||||.|::|||:||:||.....|||||..|.|.|.::.|
Human   619 CGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGC 683

  Fly   548 KFSTVCNHIHCVREGCDYILHSSSQMISHKRKHDRQDGEQAYQQFKIKQD----VEESSLDAMPQ 608
            .:|...||.||:|.||.:...|:|||.||||||:|:         .|:..    :..|.|.|...
Human   684 VYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERR---------HIRSSGALGLPPSLLGAKDT 739

  Fly   609 QQQQQQQQQPTSLSQSQSSSSVCGGSNTSTPLSSLSAEHFLARKRG----RPPKKIQLPADAQQS 669
            :.::.........|...|.:|....|.||...|:..|....|.:.|    :||
Human   740 EHEESSNDDLVDFSALSSKNSSLSASPTSQQSSASLAAATAATEAGPSATKPP------------ 792

  Fly   670 EAKRLKVEDESSNPAMLLPQSQPAAAVHPLTSGLFPGLLPAAAAPGVDPTAPNFQLTHLMALFQL 734
                      :|..:.||||            || ||.:|.|.|               ::...|
Human   793 ----------NSKISGLLPQ------------GL-PGSIPLALA---------------LSNSGL 819

  Fly   735 QNPLFYQNLYPGMTQNSSMLGNLAALSAASAAAAAAA-------AANGAGVQQPKAEFS 786
            ..|..|..:..|....|..:|..:.|.|.|:.:||:|       .|:|||...|.|..|
Human   820 PTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLVASGAGDSAPVAAAS 878

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4377
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006505
OrthoInspector	1	1.000	-	-		oto89241
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12451
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8092
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.920