DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and CAPN3

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_000061.1	Gene:	CAPN3 / 825	HGNCID:	1480	Length:	821	Species:	Homo sapiens

Alignment Length:	698	Identity:	170/698 - (24%)
Similarity:	270/698 - (38%)	Gaps:	212/698 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   952 SPRGLASAVLGE---ALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSE 1013
            :|.|:.||::..   .:|.|                        |:|     ::.:.:.|.:...
Human    38 NPSGIYSAIISRNFPIIGVK------------------------EKT-----FEQLHKKCLEKKV 73

  Fly  1014 LFVDDSFPPAPKSLYYNPASGAGEGNPV-VQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLG 1077
            |:||..|||...||:|:      :..|: ..|:||.|| |:...:......||    |||||.||
Human    74 LYVDPEFPPDETSLFYS------QKFPIQFVWKRPPEI-CENPRFIIDGANRT----DICQGELG 127

  Fly  1078 NCWLLSALAVLAEREDLVKEVLVTKEICGQ---GAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVY 1139
            :||.|:|:|.|...:.|:..|:...:...:   |.:..:..:.|:|..|::||.|| .....||:
Human   128 DCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLP-TYNNQLVF 191

  Fly  1140 SQAK-RKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDK 1203
            :::. |.:.|..|:|||.||:||.||||..|...|.:...||...|...::  ..|......:.|
Human   192 TKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIR--DAPSDMYKIMKK 254

  Fly  1204 DLIWAQLLSSRC-----VRFLMGASCGGGNM---------KVDEEEYQQKGLRPR---------- 1244
            .:....|:.  |     .....|.|..|.||         .:|....|...|.||
Human   255 AIERGSLMG--CSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTI 317

  Fly  1245 ----------------HAYSV--LDVKDIQGH--RLLKLRNPWGHYSWRGDWSDDSSLWT--DDL 1287
                            |||||  ||....:|.  :|::||||||...|.|.|||....|:  |..
Human   318 IPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKD 382

  Fly  1288 RDALMPHGASE-GVFWISFEDVLNYFDCIDICKVRSG---------W----NEVR-LQGTLQPLC 1337
            ..|.:.|..:| |.||:|:||.:.:|..::||.:.:.         |    ||.| ::|     |
Human   383 EKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRG-----C 442

  Fly  1338 SI-SC------------VLLTVLE----PTEAE------FTLFQEGQRNSEKSQRSQLDLCVVIF 1379
            |. .|            ..|.:||    |.::|      ..|.|:.:|...|...|...:...|:
Human   443 SAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIY 507

  Fly  1380 RTRSPAAPEIGR--------------LVEHSKRQVRGFVGCHKMLER-----DIYLLVCLAFNHW 1425
                    |:.:              |...||.:.:.::...::.:|     ..|::|...:
Human   508 --------EVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTY--- 561

  Fly  1426 HTGIEDPHQYPQCILAIHSSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGW 1490
                 :|||..:.||.:.|.||.|.|::..:  :..|..:....||.
Human   562 -----EPHQEGEFILRVFSEKRNLSEEVENT--ISVDRPVKKKKTKP------------------ 601

  Fly  1491 AGLVVMVENR-HENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQ 1537
               ::.|.:| :.||.:.|..:.:|        |:.||   .|..|:|
Human   602 ---IIFVSDRANSNKELGVDQESEE--------GKGKT---SPDKQKQ 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035	0/1 (0%)
		RanBP2-type Zn finger	931..950	CDD:275376
		CysPc	1001..1328	CDD:128526	114/391 (29%)
CAPN3	NP_000061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	7..37
		Peptidase_C2	75..415	CDD:279042	108/355 (30%)
		Domain III	418..586		36/188 (19%)
		Calpain_III	429..579	CDD:279416	33/170 (19%)
		Calpain_u2	583..653	CDD:293254	15/87 (17%)
		Linker	587..649		15/83 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..652		10/38 (26%)
		Domain IV	650..821
		EFh	653..721	CDD:238008
		EFh	697..751	CDD:238008
		EFh	728..817	CDD:298682
		EF-hand_7	728..784	CDD:290234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820