Protein Alignment sol and CAPN1

DIOPT Version :10

• Sequence 1: NP_476738.3
• Gene: sol / 44014
• FlyBaseID: FBgn0003464
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_005177.2
• Gene: CAPN1 / 823
• HGNCID: 1476
• Length: 714
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 128/401 - (31%)
• Similarity: 185/401 - (46%)
• Gaps: 74/401 - (18%)

  Fly   974 LTPADIRQESKLMENLRQLEETEALTKWQNIIQY-----------CRDNSELFVDDSFPPAPKSL 1027
            :||......|..::..|..|  ..|.:.:|.|:|           |..:..||.|::|||.|:||
Human     6 ITPVYCTGVSAQVQKQRARE--LGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSL 68

  Fly  1028 YY---NPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLA 1089
            .|   .|.|....|   ::|:||.|:..:     |..:......:|||||.||:||||:|:|.|.
Human    69 GYKDLGPNSSKTYG---IKWKRPTELLSN-----PQFIVDGATRTDICQGALGDCWLLAAIASLT 125

  Fly  1090 EREDLVKEVLVTKEICGQ-------GAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVY-SQAKRKQ 1146
            ..:.|:..|:..    ||       |.:..:|.:.|:|..|:||||||. |.|.||: ..|:..:
Human   126 LNDTLLHRVVPH----GQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPI-KDGKLVFVHSAEGNE 185

  Fly  1147 LWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLL 1211
            .|..|:|||.||::|.||||..|...||....||...|...|:.:    ||:       ::..:|
Human   186 FWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKA----PSD-------LYQIIL 239

  Fly  1212 SSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDI----QGHRLLKLRNPWGHYSW 1272
            .:.....|:|.|....:: :|.|....|.|...|||||...|.:    |...|:::|||||...|
Human   240 KALERGSLLGCSIDISSV-LDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEW 303

  Fly  1273 RGDWSDDSSLWT-------DDLRDALMPHGASEGVFWISFEDVLNYFDCIDICKVRSG------- 1323
            .|.|||.||.|.       |.||..:     .:|.||:||.|.:..|..::||.:...
Human   304 TGAWSDSSSEWNNVDPYERDQLRVKM-----EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTI 363

  Fly  1324 --WNEVRLQGT 1332
              ||....:||
Human   364 RKWNTTLYEGT 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:395516
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:395516
		zf-RanBP	643..672	CDD:395516
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:395516
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:395516
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:395516
		CysPc	1001..1328	CDD:128526	120/368 (33%)
CAPN1	NP_005177.2	Peptidase_C2	56..352	CDD:459889	112/325 (34%)
		Domain III	355..526		4/20 (20%)
		Calpain_III	364..524	CDD:238132	4/11 (36%)
		Linker	527..542
		Domain IV	543..713
		EFh_PEF_CAPN1	546..714	CDD:320073
		EF-hand motif	546..574	CDD:320073
		EF-hand motif	589..618	CDD:320073
		EF-hand motif	619..649	CDD:320073
		EF-hand motif	655..683	CDD:320073
		EF-hand motif	685..714	CDD:320073