DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sol and capn7

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_001128580.1	Gene:	capn7 / 556792	ZFINID:	ZDB-GENE-111111-1	Length:	815	Species:	Danio rerio

Alignment Length:	742	Identity:	178/742 - (23%)
Similarity:	282/742 - (38%)	Gaps:	227/742 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   721 AMACVVCG--GSKLKSISSIEDMTLRKGEFWTCSHCTLKNSLHSPVCSACKSHRQPQLSMAMEAV 783
            |.|.:..|  ||||::|....:..|.:.:       ||.:::.:......||..|..|..|...|
Zfish    37 AQALIYAGMAGSKLENIQDKVNEYLDRVQ-------TLLSAVQAQSSDPLKSKHQLDLERAYFLV 94

  Fly   784 RERPDGQSYEEQDAAAVGGGGGSAHQSGANEVKAPTALNLPLTSVALPMPMLQLPTSTAAGLRGS 848
            .     |::||.:            :..|:|     |:.|...:|.|.:
Zfish    95 T-----QAFEEDE------------KENADE-----AIELYTQAVELCI---------------- 121

  Fly   849 RSPSPRMQLLPSLQQQRNSSSSGAIPKRHSTGGSIVPRNISIAGLANYNLQQGQGVGSASVVSAS 913
                          |..|.:|..|:..:             :..||...|.:.:|:..:....||
Zfish   122 --------------QASNETSDPALQAK-------------LKQLARQALDRAEGLKDSVSKPAS 159

  Fly   914 GAGSGAGAVGASTSTKKWQCPACTYDNCAASVVCDICSSPRGLASAVLGEALGRKSVRVALTPAD 978
            ....|:.|.......:::                    .|.|...::..:|   :.||.|
Zfish   160 QDKPGSSASKGPAQVRQF--------------------FPLGPDFSIHDKA---QPVRAA----- 196

  Fly   979 IRQESKLMENLRQLEETEALTKWQNI--IQYCR----DNSELFVDDSFP-------------PAP 1024
              |.|:........||.|.|.|...:  |:|..    |..|.|   :||             |..
Zfish   197 --QSSEPQGQRYTAEEIEVLRKTSKVNGIEYVPFMSVDLRERF---AFPVPFSDKCGKLALSPKQ 256

  Fly  1025 KSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLA 1089
            ::::             .:|.||.:| |:.    |..:| |.....|.|.|:.:|..:::||:.|
Zfish   257 RAIF-------------SRWVRPDDI-CNN----PTMIF-TVSSFSIKQTVVSDCSFVASLAISA 302

  Fly  1090 EREDLVKEVLVTKEICGQ-----------GAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYS-QA 1142
            ..|....:.|:|..|..|           |.|.|:|..:|....|::||.||.|:.|.|:.| .:
Zfish   303 AYERRYSKKLITSIIYPQNRKGEPEYNPCGKYMVKLHINGVPRKVIIDDFLPVDRNGELLCSYSS 367

  Fly  1143 KRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIW 1207
            .|.:|||.|||||..|:.|.|:...|...|: |..|||...|.|.:.:.:.....:|..
Zfish   368 NRNELWVSLIEKAYMKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDNQSFNKDDTF------ 425

  Fly  1208 AQLLSSRCVR--FLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQGHRLLKLRNPWGHY 1270
             ::|..|..|  .|:..:.|    .:.|||.::.||.|.|||:|||::..:..|.|:|:|||.|.
Zfish   426 -RMLYQRFHRGDVLITTATG----VMTEEEGERWGLVPTHAYAVLDIRQYKDKRFLQLKNPWSHL 485

  Fly  1271 SWRGDWSD-DSSLWTDDLRDALM--PHGASE---GVFWISFEDVLNYFDCIDI-----------C 1318
            .|:|.:|: |...||.||...|.  |..|.:   |||||.:||:..|:|.|.:           |
Zfish   486 RWKGSYSERDEKNWTPDLLKYLNFDPKTAQKFDNGVFWIIWEDLCQYYDVIYLSWNPALFKESSC 550

  Fly  1319 KVRSGWNEVRLQGTLQPLCS----------ISC--------VLLTVLEPTEAEFTLFQEGQRNSE 1365
             :.|.|:  ..||.::.:.|          :.|        ||||.....:.:|.      :|.|
Zfish   551 -IHSSWD--GKQGPVKDVYSLANNPQYKLEVQCPQGGAAVWVLLTRHITDKDDFA------QNRE 606

  Fly  1366 KSQRSQLDLCVVIFRTRS-----PAAP 1387
                   .:.:|:::|..     ||.|
Zfish   607 -------FITLVVYKTNGKKVYYPAEP 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035	4/11 (36%)
		RanBP2-type Zn finger	708..727	CDD:275376	2/5 (40%)
		zf-RanBP	747..774	CDD:279035	4/26 (15%)
		RanBP2-type Zn finger	749..768	CDD:275376	2/18 (11%)
		zf-RanBP	927..954	CDD:279035	0/26 (0%)
		RanBP2-type Zn finger	931..950	CDD:275376	0/18 (0%)
		CysPc	1001..1328	CDD:128526	111/376 (30%)
capn7	NP_001128580.1	MIT	5..76	CDD:294211	11/45 (24%)
		MIT	85..159	CDD:294211	20/138 (14%)
		CysPc	216..540	CDD:238004	109/357 (31%)
		Calpain_III	570..682	CDD:294111	13/70 (19%)
		calpain_III	689..812	CDD:214786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111762at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920