Protein Alignment sol and CAPN14

DIOPT Version :10

• Sequence 1: NP_476738.3
• Gene: sol / 44014
• FlyBaseID: FBgn0003464
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_001138594.1
• Gene: CAPN14 / 440854
• HGNCID: 16664
• Length: 684
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 159/648 - (24%)
• Similarity: 254/648 - (39%)
• Gaps: 147/648 - (22%)

  Fly  1001 WQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGN------PVVQWRRPHEINCDGGAYPP 1059
            ::.::..|..|..||.|.|||....|:        |.|:      |.:||:||.|::.:     |
Human    30 FEALLAECLRNGCLFEDTSFPATLSSI--------GSGSLLQKLPPRLQWKRPPELHSN-----P 81

  Fly  1060 WAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQ---GAYQVRLCKDGKWT 1121
            ...|......|:|||::|:||.|:||..||..:|::..|:...:...:   |.::......|.|.
Human    82 QFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146

  Fly  1122 TVLVDDLLPCDKRGHLVYSQAKRKQL-WVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCES 1185
            .|::||.||.::.|.||:..:..|.| |..|:|||.||:.|.||.|.||:..|.|...||....:
Human   147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMT 211

  Fly  1186 IPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVL 1250
            |.|..:           ...:|..|:.:...|.|:|.....|      |:..:.||...|||::.
Human   212 INLAEA-----------HGNLWDILIEATYNRTLIGCQTHSG------EKILENGLVEGHAYTLT 259

  Fly  1251 DVKDIQ-GHR---LLKLRNPWGHYSWRGDWSDDSSLW--TDDLRDALMPHGASEGVFWISFEDVL 1309
            .::.:. .||   |:|||||||...|:|||||.||.|  .......|:....::|.||::.:|..
Human   260 GIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFK 324

  Fly  1310 NYFDCIDICKVRSG------------------WNEVRLQGTLQPLCSISC-----VLLTVLEPTE 1351
            .:|..:.|||:..|                  |.:....|..:.|...:.     .||:|..|.|
Human   325 THFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEE 389

  Fly  1352 AE---------FTLFQEGQRNSEKSQ----------------RSQLDLCVVIFRTRSP-AAPEIG 1390
            ..         .:|.|:.:....|.:                ..|..|....|:..:| :.|:
Human   390 GRRSLRPCSVLVSLLQKPRHRCRKRKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPD-- 452

  Fly  1391 RLVEHSKRQVRGFVGCHKMLERDIYLLV-CLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQIS 1454
            |.::..:      |.....||...||:| |         |.:.||..:.:|.:.|.|.:..|..|
Human   453 RFLKEKE------VSQELCLEPGTYLIVPC---------ILEAHQKSEFVLRVFSRKHIFYEIGS 502

  Fly  1455 PSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVV 1519
            .|..:.:..|      :.|.....|..|.::........|.:....::..|
Human   503 NSGVVFSKEI------EDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTW-------------- 547

  Fly  1520 STRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSI------------AHRLTHRLANSRGLHDW 1570
            |:.|..:...|:...|.  |:.|..|..||..||            :.::.|:.....|..:|
Human   548 SSLGSRQPFFSLEACQG--ILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRGSGYLNW 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:395516
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:395516
		zf-RanBP	643..672	CDD:395516
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:395516
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:395516
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:395516
		CysPc	1001..1328	CDD:128526	107/360 (30%)
CAPN14	NP_001138594.1	Peptidase_C2	44..334	CDD:459889	100/319 (31%)
		Domain III	337..503		32/182 (18%)
		Calpain_III	354..491	CDD:460050	28/153 (18%)
		Linker	504..517		3/18 (17%)
		Domain IV	518..683		18/107 (17%)
		EFh_PEF_CAPN13_14	519..684	CDD:320070	18/106 (17%)
		EF-hand motif	519..546	CDD:320070	3/26 (12%)
		EF-hand motif	561..590	CDD:320070	8/30 (27%)
		EF-hand motif	591..620	CDD:320070	3/18 (17%)
		EF-hand motif	626..654	CDD:320070
		EF-hand motif	656..684	CDD:320070