DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sol and Capn13

DIOPT Version :9

Sequence 1:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_001020304.1	Gene:	Capn13 / 362701	RGDID:	1562682	Length:	668	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	121/450 - (26%)
Similarity:	191/450 - (42%)	Gaps:	89/450 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   992 LEETEALTKWQN-----IIQYCRDNSELFVDDSFPPAPKSLYYNPASG----AGEGNPVVQWRRP 1047
            |||| ::.|::|     :...|....:||:||:||....|:      |    .|:..|.::|:||
  Rat     8 LEET-SVVKFKNQDFRFLRDRCLSRGQLFIDDTFPAEASSI------GQKLLMGKRLPKLEWKRP 65

  Fly  1048 HEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQ--GAY 1110
            .:::..    ||..:.......||.||..|:||.|:||..|.:....::::|:.:....|  |.:
  Rat    66 QDLSFG----PPHFILEGASRFDIQQGRAGDCWFLAALGSLTQNPQCLQKILMNQSFSYQYAGIF 126

  Fly  1111 QVRLCKDGKWTTVLVDDLLP------CDKRGHLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSG 1169
            ..|..:.|:|..|::||.||      |     .|:.:...::.|..|:|||.||:.|.|..|..|
  Rat   127 HFRFWQCGQWVEVVIDDRLPVVGNNFC-----FVHPRRGNQEFWPCLMEKAYAKLLGSYSQLHYG 186

  Fly  1170 RAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEE 1234
            ...:.|..|||.....|.|.:|    ||      ||:   ::....|:.....:|.......:|.
  Rat   187 YLPDALVDLTGGVVTRINLHSS----PS------DLL---MVVKTAVQTGSMVACATPKWLTEES 238

  Fly  1235 EYQQKGLRPRHAYSVLDVKDIQGHR----LLKLRNPWGHYSWRGDWSDDSSLW--TDDLRDALMP 1293
            |..:.||..:|||:|...:.||..|    :::|.||||:..|||.|.|.|..|  |...|.:.:.
  Rat   239 EVMENGLVSQHAYTVTGAEKIQYRRGWEEIIRLWNPWGNTEWRGRWGDGSQEWWETHGSRKSQLY 303

  Fly  1294 HGASEGVFWISFEDVLNYFDCIDICK-----------VRSGWNEVRLQGTLQPLCSIS------- 1340
            ....:|.||:|..|....|.|:.||.           ....|.::|.:..:     ||
  Rat   304 ENKDDGEFWMSCRDFHENFSCLYICSQFPITMDPGVTPNESWRQMRFKNQV-----ISGNTAGGD 363

  Fly  1341 ----CVLLTVLEPTEAE-----FTLFQEGQRNSE-----KSQRSQLDLCVVIFRTRSPAA 1386
                ..|..|.||.:..     ||:..:..:..|     :.|..::|.....|:.|.|.|
  Rat   364 GRDIQYLFDVQEPMDGNNVIVAFTVMPQSLKTEEWPFPLQFQVFKVDSQFQKFQKRLPPA 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035
		RanBP2-type Zn finger	931..950	CDD:275376
		CysPc	1001..1328	CDD:128526	100/360 (28%)
Capn13	NP_001020304.1	Peptidase_C2	35..329	CDD:279042	95/321 (30%)
Capn13	NP_001020304.1	Calpain_III	345..477	CDD:294111	16/83 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820